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No. Gene SKU Publication Pubmed Link
15-methyl cytosineAMM99021Maki, W. C. et al. Nanowire-transistor based ultra-sensitive DNA methylation detection. Biosens. Bioelectron. 23, 780-7 (2008). 1793661117936611
25-methyl cytosineAMM99021Zhang, W., Lee, H.-R., Koo, D.-H. & Jiang, J. Epigenetic modification of centromeric chromatin: hypomethylation of DNA sequences in the CENH3-associated chromatin in Arabidopsis thaliana and maize. Plant Cell 20, 25-34 (2008). 1823913318239133
35-methyl cytosineAMM99021Jensen, T. J., Novak, P., Eblin, K. E., Gandolfi, A. J. & Futscher, B. W. Epigenetic remodeling during arsenical-induced malignant transformation. Carcinogenesis 29, 1500-8 (2008). 1844848418448484
45-methyl cytosineAMM99021Zhang, W., Wang, X., Yu, Q., Ming, R. & Jiang, J. DNA methylation and heterochromatinization in the male-specific region of the primitive Y chromosome of papaya. Genome Res. 18, 1938-43 (2008). 1859381418593814
55-methyl cytosineAMM99021Minardi, D. et al. Prognostic role of global DNA-methylation and histone acetylation in pT1a clear cell renal carcinoma in partial nephrectomy specimens. J. Cell. Mol. Med. 13, 2115-21 (2009). 1875263318752633
65-methyl cytosineAMM99021Vrba, L., Junk, D. J., Novak, P. & Futscher, B. W. p53 induces distinct epigenetic states at its direct target promoters. BMC Genomics 9, 486 (2008). 1892218318922183
75-methyl cytosineAMM99021Walsh, T. K. et al. A functional DNA methylation system in the pea aphid, Acyrthosiphon pisum. Insect Mol. Biol. 19 Suppl 2, 215-28 (2010). 2048265220482652
85-methyl cytosineAMM99021Ribas, R. et al. Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments. Dev. Biol. 355, 372-80 (2011). 2149775621497756
95-methyl cytosineAMM99021Macaulay, E. C., Weeks, R. J., Andrews, S. & Morison, I. M. Hypomethylation of functional retrotransposon-derived genes in the human placenta. Mamm. Genome 22, 722-35 (2011). 2187438621874386
105-methyl cytosineAMM99021Kurita, R., Arai, K., Nakamoto, K., Kato, D. & Niwa, O. Determination of DNA methylation using electrochemiluminescence with surface accumulable coreactant. Anal. Chem. 84, 1799-803 (2012). 2226369022263690
115-methyl cytosineAMM99021Kurita, R. & Niwa, O. DNA methylation analysis triggered by bulge specific immuno-recognition. Anal. Chem. 84, 7533-8 (2012). 2288079722880797
125-methyl cytosineAMM99021Gertych, A., Oh, J. H., Wawrowsky, K. A., Weisenberger, D. J. & Tajbakhsh, J. 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models. BMC Pharmacol. Toxicol. 14, 11 (2013). 2339416123394161
135-methyl cytosineAMM99021Tajbakhsh, J. Covisualization of methylcytosine, global DNA, and protein biomarkers for In Situ 3D DNA methylation phenotyping of stem cells. Methods Mol. Biol. 1052, 77-88 (2013). 2359203223592032
145-methyl cytosineAMM99021Fukuda, K. et al. Regional DNA methylation differences between humans and chimpanzees are associated with genetic changes, transcriptional divergence and disease genes. J. Hum. Genet. 58, 446-54 (2013). 2373912723739127
155-MethylcytosineAMM99021Microplate-based platform for combined chromatin and DNA methylation immunoprecipitation assays. BMC Mol Biol. 12, 49 (2011). 2209870922098709
165-MethylcytosineAMM99021Physical localization and DNA methylation of 45S rRNA gene loci in Jatropha curcas L. PLoS One. 8, e84284 (2014). 2438636224386362
175-MethylcytosineAMM99021The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice. EMBO J. 34, 748-58 (2015). 2551995525519955
185-MethylcytosineAMM99021Dynamic heterogeneity of DNA methylation and hydroxymethylation in embryonic stem cell populations captured by single-cell 3D high-content analysis. Exp Cell Res. 332, 190-201 (2015). 2570072925700729
195-MethylcytosineAMM99021Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. Stem Cell Reports. 9, 329-341 (2017). 2857939428579394
205-MethylcytosineAMM99021Prostate cancer diagnosis using epigenetic biomarkers, 3D high-content imaging and probabilistic cell-by-cell classifiers. Oncotarget. 8, 57278-57301 (2017). 2891567028915670
215-MethylcytosineAMM99021Utility of 5-Methylcytosine Immunohistochemical Staining to Assess Global DNA Methylation and Its Prognostic Impact in MDS Patients. Asian Pac J Cancer Prev. 18, 3307-3313 (2017). 2928622429286224
225-MethylcytosineAMM99021PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation. Stem Cell Res. 27, 46-56 (2018). 2932425429324254
235-MethylcytosineAMM99021Siyuan Chang, et al. Epigenetic regulation of osteopontin splicing isoform c defines its role as a microenvironmental factor to promote the survival of colon cancer cells from 5-FU treatment. 452 (2020). 3294400032944000
245-MethylcytosineAMM99021Global acetylation and methylation changes predict papillary urothelial neoplasia of low malignant potential recurrence: a quantitative analysis. Int J Immunopathol Pharmacol. 24, 489-97 (2011) 2165832321658323
255-MethylcytosineAMM99021Conformation-selective methylation of geminivirus DNA. J Virol. 85, 12001-12 (2011) 2183580421835804
265-MethylcytosineAMM99021Single cell epigenetic visualization assay. Nucleic Acids Res. (2021). 3351140033511400
27AADCARP41425_T100Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. Exp. Neurol. 293, 1-12 (2017). 2833639428336394
28ABCC4OAEB02455Xu, S., Weerachayaphorn, J., Cai, S.-Y., Soroka, C. J. & Boyer, J. L. Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Am. J. Physiol. Gastrointest. Liver Physiol. 299, G126-35 (2010). 2039553520395535
29ABCC4OAEB02455Weerachayaphorn, J. et al. Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 302, G925-36 (2012). 2234555022345550
30ABCC4OAEB02455Gori, I. et al. Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4). Fertil. Steril. 99, 1965-73.e2 (2013). 2347295023472950
31ABCC4OAEB02455Montani, M. et al. Multidrug resistance protein 4 (MRP4) expression in prostate cancer is associated with androgen signaling and decreases with tumor progression. Virchows Arch. 462, 437-43 (2013). 2350386723503867
32ABCC8ARP43622_P050Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters. Toxicol. Appl. Pharmacol. 310, 215-228 (2016). 2766457727664577
33ABCG1OAAB03522Fu, Y. et al. ABCA12 Regulates ABCA1-Dependent Cholesterol Efflux from Macrophages and the Development of Atherosclerosis. Cell Metab. 18, 225-38 (2013). 2393175423931754
34ABL1OAAF07465Retinal Pigment Epithelium and Neural Retinal Progenitors Interact via Semaphorin 6D to Facilitate Optic Cup Morphogenesis. Eneuro 2021 3 8 NULL 3381108633811086
35ABP1ARP41908_P050Liang, X.-H. et al. Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization. Endocrinology 151, 5007-16 (2010). 2066802720668027
36ACAA1ARP48177_P050Mouse hepatocytes and LSEC proteome reveal novel mechanisms of ischemia/reperfusion damage and protection by A2aR stimulation. J Hepatol 573-80 62 3 March 201525315650
37ACADVLARP54486_P050Yoon, S.-W., Kang, S., Ryu, S.-E. & Poo, H. Identification of tyrosine-nitrated proteins in HT22 hippocampal cells during glutamate-induced oxidative stress. Cell Prolif. 43, 584-93 (2010). 2103999721039997
38ACE2ARP53751_P050ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice. Mol. Ther. 23, 1434-43 (2015). 2599742825997428
39ACE2ARP53751_P050Plasma and tissue angiotensin-converting enzyme 2 activity and plasma equilibrium concentrations of angiotensin peptides in dogs with heart disease. J Vet Intern Med. 33, 1571-1584 (2019). 3125430831254308
40ACE2ARP53751_P050Tropism of SARS-CoV-2, SARS-CoV and influenza virus in canine tissue explants. J Infect Dis. (2021). 3339548433395484
41ACLYARP42737_P050Infantino, V., Iacobazzi, V., Palmieri, F. & Menga, A. ATP-citrate lyase is essential for macrophage inflammatory response. Biochem. Biophys. Res. Commun. 440, 105-11 (2013). 2405109124051091
42ACLYARP42737_P050Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis. Cancer Discov. 9, 416-435 (2019). 3062659030626590
43ACLYOAGA04026ATP-citrate lyase promotes axonal transport across species. Nat Commun. 12, 5878 (2021) 3462084534620845
44ACLYOASG00647Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes. J Biol Chem. 293, 12259-12270 (2018). 2992997929929979
45ACO1ARP40390_P050Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism. Biomolecules. 9, (2019). 3082358730823587
46ACO2ARP56302_P050Scheving, R. et al. Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve. J. Proteomics 75, 3987-4004 (2012). 2258812022588120
47ACSL1ARP32784_P050Golej, D. L. et al. Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells. J. Lipid Res. 52, 782-93 (2011). 2124259021242590
48ACTBOAAD00224Selective cytoprotective effect of histamine on doxorubicin-induced hepatic and cardiac toxicity in animal models. Cell Death Discov. 1, 15059 (2015). 2755148527551485
49ACTN2ARP41462_P050Yan, Z. et al. BAF250B-associated SWI/SNF chromatin-remodeling complex is required to maintain undifferentiated mouse embryonic stem cells. Stem Cells 26, 1155-65 (2008). 1832340618323406
50ACTN4ARP42202_T100Wei, S., Gao, X., Du, J., Su, J. & Xu, Z. Angiogenin enhances cell migration by regulating stress fiber assembly and focal adhesion dynamics. PLoS One 6, e28797 (2011). 2219491522194915
51ACVR2AOAAB16873Detection of Sotatercept (ACE-011) in human serum by SAR-PAGE and western single blotting. Drug Test Anal 927-937 10 6 June 201829193906
52ADAM10OAGA02442Sogorb-Esteve, A., García-Ayllón, M., Gobom, J., Alom, J., Zetterberg, H., Blennow, K. and Sáez-Valero, J. Levels of ADAM10 are reduced in Alzheimer’s disease CSF. J Neuroinflammation. 15, 213 (2018). 3004573330045733
53ADAM10OAGA02442α-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer's disease. Alzheimers Res Ther. 12, 139 (2020). 3312934433129344
54ADAMTS4ARP41556_P050Lee, C. W. et al. Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina. J. Clin. Pathol. 64, 399-404 (2011). 2134587721345877
55ADAMTS4ARP41556_P050Boerboom, D. et al. Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev. Dyn. 240, 1806-14 (2011). 2158490521584905
56ADAMTS4ARP41556_P050Lee, S.-Y. et al. Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases. Arch. Pathol. Lab. Med. 138, 643-50 (2014). 2478612124786121
57ADCYAP1R1ARP59945_P050PACAP modulation of calcium ion activity in developing granule cells of the neonatal mouse olfactory bulb. J Neurophysiol. 113, 1234-48 (2015). 2547535125475351
58ADGRG1ARP58627_P050Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism. iScience 104823 25 8 August 202235992092
59ADH4ARP43572_P050Retinoid regulation of antiviral innate immunity in hepatocytes. Hepatology. 63, 1783-95 (2016). 2663812026638120
60ADH4ARP43573_T100Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 2446527724465277
61ADIPOR2ARP60819_P050Effects of Obesity on Adiponectin System Skin Expression in Dogs: A Comparative Study. Animals (Basel). 11, NULL (2021) 3443876534438765
62ADORA1OABF01723Adenosine A1 Receptor mRNA Expression by Neurons and Glia in the Auditory Forebrain. Anat Rec (Hoboken). 301, 1882-1905 (2018). 3031563030315630
63ADORA2AOALA02443Toll-like receptor 2 induces adenosine receptor A2a and promotes human squamous carcinoma cell growth via extracellular signal regulated kinases ½. Oncotarget. 9, 6814-6829 (2018). 2946793129467931
64ADORA3ARP59956_P050Merighi, S. et al. Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells. Mol. Pharmacol. 72, 162-72 (2007). 1740076317400763
65ADPRHL2OAAB06322Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 (ARH3) reveals the basis of metal selectivity and different roles for the two Mg ions. J Biol Chem 2021 NULL NULL 100692 3389420233894202
66AEBP1ARP31592_P050Kim, H. J. et al. Identification of estradiol/ERa-regulated genes in the mouse pituitary. J. Endocrinol. 210, 309-21 (2011). 2170066021700660
67AGPAT2ARP44636_P050Fetuin-A modulates lipid mobilization in bovine adipose tissue by enhancing lipogenic activity of adipocytes. J Dairy Sci. 102, 4628-4638 (2019). 3082756430827564
68AHRARP32243_T100The AhR Ligand, TCDD, Regulates Androgen Receptor Activity Differently in Androgen-Sensitive versus Castration-Resistant Human Prostate Cancer Cells. Int J Environ Res Public Health. 12, 7506-18 (2015). 2615465826154658
69AIF1OAGA00004Adverse early life environment increases hippocampal microglia abundance in conjunction with decreased neural stem cells in juvenile mice. Int. J. Dev. Neurosci. 55, 56-65 (2016). 2766638327666383
70AIF1OAGA00004Histological Changes of the Testicular Interstitium during Postnatal Development in Microminipigs. Toxicol Pathol. 47, 469-482 (2019). 3073956530739565
71AIF1OAGA00004Spontaneous Age-Related Histopathological Changes in Microminipigs. Toxicol Pathol. 47, 817-832 (2019). 3133728031337280
72AKR1B10OAGA00776LncRNA 1700020I14Rik promotes AKR1B10 expression and activates Erk pathway to induce hepatocyte damage in alcoholic hepatitis. Cell Death Discov 374 8 1 August 202236028503
73AKR1C1OAGA00409Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing. Sci Rep. 9, 10457 (2019). 3132066731320667
74AKR1C1OAGA00409Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity. Front Endocrinol (Lausanne). 11, 599869 (2021). 3358453833584538
75AKTOAAF00965Tsai, T.-C. et al. The paracrine effect of exogenous growth hormone alleviates dysmorphogenesis caused by tbx5 deficiency in zebrafish (Danio rerio) embryos. J. Biomed. Sci. 19, 63 (2012). 2277602322776023
76AKT1AVARP06008_P050The RNA helicase DDX3 induces neural crest by promoting AKT activity. Development. NULL, NULL (2020) 3331814933318149
77AKT1AVARP06008_P050The RNA helicase DDX3 induces neural crest by promoting AKT activity. Development 2020 NULL NULL NULL 3400494434004944
78ALADARP41657_P050Iron metabolic pathways in the processes of sponge plasticity. PLoS One. 15, e0228722 (2020). 3208415932084159
79ALBARP41746_P050Holzer, M. et al. Uremia alters HDL composition and function. J. Am. Soc. Nephrol. 22, 1631-41 (2011). 2180409121804091
80ALG11ARP44463_P050Rind, N. et al. A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip. Hum. Mol. Genet. 19, 1413-24 (2010). 2008093720080937
81ALKBH1OACA06689ALKBH1-demethylated DNA N6-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease. J Clin Invest. 131, NULL (2021) 3400380034003800
82AMHARP54312_P050Tezak, B., I. Romero, S. Milton and J. Wyneken. Identifying Sex of Neonate Turtles with Temperature-dependent Sex Determination via Small Blood Samples. Sci Rep. 2020; 10: 5012. 3219346432193464
83AMHARP54312_P050Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows. J Vet Med Sci. 82, 1113-1117 (2020). 3255495532554955
84AMHARP54312_P050Bovine gonadotrophs express anti-Müllerian hormone (AMH): comparison of AMH mRNA and protein expression levels between old Holsteins and young and old Japanese Black females. Reprod Fertil Dev. 31, 810-819 (2019) 3055459030554590
85AMHARP54312_P050Anti-Müllerian hormone and its receptor are detected in most gonadotropin-releasing-hormone cell bodies and fibers in heifer brains. Domest Anim Endocrinol. 72, 106432 (2020) 3216975432169754
86AMHOAAB06540Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family. Proc Natl Acad Sci U S A. 118 (2021) 3415511834155118
87AMOTARP34660_P050VCAM-1 induces signals that stimulate ZO-1 serine phosphorylation and reduces ZO-1 localization at lung endothelial cell junctions. J Leukoc Biol. 104, 215-228 (2018). 2988998429889984
88ANK1ARP42566_T100Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. J Cell Sci. 122, 2640-50 (2009). 1958409519584095
89ANK1ARP42566_T100Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers. J Cell Biol. 194, 105-20 (2011). 2172719521727195
90ANK1ARP42566_T100Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Mol Biol Cell. 23, 2490-504 (2012). 2257388722573887
91ANK1ARP42566_T100Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms. FEBS J. 285, 481-500 (2018). 2926572829265728
92ANKHOAAB06341Szeri, et al. The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP. PLoS Genetics 2020 Jul 8;16(7):e1008884. 3263999632639996
93ANKHOAAB06341The Mineralization Regulator ANKH Mediates Cellular Efflux of ATP, Not Pyrophosphate. J Bone Miner Res 1024-1031 37 5 May 202235147247
94ANKRD11ARP33542_T100Characterization of ANKRD11 mutations in humans and mice related to KBG syndrome. Hum Genet 2015 2 134 181-90 2541369825413698
95ANO4OACA04834Influence of Anoctamin-4 and -9 on ADAM10 and ADAM17 Sheddase Function. Membranes (Basel) 2022 2 12 NULL 3520704435207044
96ANXA1ARP36568_T100Nordon, I. M. et al. Comparative proteomics reveals a systemic vulnerability in the vasculature of patients with abdominal aortic aneurysms. J. Vasc. Surg. 54, 1100-1108.e6 (2011). 2174179421741794
97ANXA1ARP36568_T100Ishida, Y. et al. Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion: proteomic approach using fluorescent two-dimensional differential gel electrophoresis. Hum. Cell 27, 68-77 (2014). 2432376524323765
98ANXA2OAAF00618Annexin A2 binds the internal ribosomal entry site of c-myc mRNA and regulates its translation. RNA Biol 2021 sup1 18 337-354 3434629234346292
99ANXA3ARP36578_T100Seliger, B. et al. Combined analysis of transcriptome and proteome data as a tool for the identification of candidate biomarkers in renal cell carcinoma. Proteomics 9, 1567-81 (2009). 1923516619235166
100ANXA3ARP36578_T100Schordan, S. et al. Alterations of the podocyte proteome in response to high glucose concentrations. Proteomics 9, 4519-28 (2009). 1968872419688724
101ANXA3ARP36578_T100Bianchi, C. et al. Primary cell cultures from human renal cortex and renal-cell carcinoma evidence a differential expression of two spliced isoforms of Annexin A3. Am. J. Pathol. 176, 1660-70 (2010). 2016785620167856
102ANXA3ARP36578_T100Meyer-Schwesinger, C. et al. Nephrotic syndrome and subepithelial deposits in a mouse model of immune-mediated anti-podocyte glomerulonephritis. J. Immunol. 187, 3218-29 (2011). 2184438621844386
103ANXA4ARP36686_T100de la Cuesta, F. et al. A proteomic focus on the alterations occurring at the human atherosclerotic coronary intima. Mol. Cell. Proteomics 10, M110.003517 (2011). 2124824721248247
104ANXA4ARP36686_T100Staquicini, F. I. et al. Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. Proc. Natl. Acad. Sci. U. S. A. 108, 18637-42 (2011). 2204933922049339
105AOC1ARP41908_P050Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease. Sci Adv. 5, eaav0316 (2019). 3090686130906861
106APOEARP54283_P050Rohn, T. T., Catlin, L. W., Coonse, K. G. & Habig, J. W. Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer’s disease brain. Brain Res. 1475, 106-15 (2012). 2290276722902767
107APOEARP54283_P050Rohn, T. T., Day, R. J., Sheffield, C. B., Rajic, A. J. & Poon, W. W. Apolipoprotein E pathology in vascular dementia. Int. J. Clin. Exp. Pathol. 7, 938-47 (2014). 2469671224696712
108APOEARP54283_P050Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain. Aging Dis. 7, 267-77 (2016). 2733084127330841
109APOEARP54283_P050Nuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimer's disease brain. Int J Physiol Pathophysiol Pharmacol. 9, 40-57 (2017). 2853389128533891
110APOEARP54283_P050Evaluation of Apolipoprotein E Fragmentation as a Biomarker for Alzheimer's Disease. J Neurol Neurol Disord. 3, (2017). 2952037929520379
111APOEARP54283_P050Fragmentation of Apolipoprotein E4 is Required for Differential Expression of Inflammation and Activation Related Genes in Microglia Cells. Int J Neurodegener Dis 2021 1 4 NULL 3469329534693295
112APOOOAAB09635Adult-onset obesity is triggered by impaired mitochondrial gene expression. Sci Adv. 3, e1700677 (2017). 2883592128835921
113APTXARP40014_T100Dopeso, H. et al. Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment. Clin. Cancer Res. 16, 2375-82 (2010). 2037167620371676
114AQp4OABB01958Astrogliogenesis in human fetal brain: complex spatiotemporal immunoreactivity patterns of GFAP, S100, AQP4 and YKL-40. J Anat 2019 3 235 590-615 3090108030901080
115AQUAPORIN 4OABB01958PDGF-B Is Required for Development of the Glymphatic System. Cell Rep. 26, 2955-2969.e3 (2019). 3086588630865886
116AREB6ARP30976_P050Kothandaraman, N. et al. E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer. BMC Cancer 10, 64 (2010). 2018123020181230
117ARF6ARP54598_P050Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse. Elife. 5, (2016). 2673151826731518
118ARG1ARP45672_T100Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 2446527724465277
119ARG1OAEB02142Jäger, K. et al. Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome. Graefes Arch. Clin. Exp. Ophthalmol. 251, 1995-2002 (2013). 2374051923740519
120ARHGDIAOAAI00735α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions. BMC Biol 2021 1 19 130 3415805334158053
121ARHGEF7OASG05888Platelet-derived growth factor receptor-a and Ras-related C3 botulinum toxin substrate-1 regulate mechano-responsiveness of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 313, L1174-L1187 (2017). 2877509728775097
122ARNTARP30979_P050Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult. J. Physiol. (Lond.). 2657416226574162
123ASAH1OAPB00726Increased placental mitochondrial fusion in gestational diabetes mellitus: an adaptive mechanism to optimize feto-placental metabolic homeostasis?. BMJ Open Diabetes Res Care. 8, (2020). 3214413032144130
124ASAHLARP44939_P050A quantitative study on splice variants of N-acylethanolamine acid amidase in human prostate cancer cells and other cells. Biochim. Biophys. Acta. 1861, 1951-1958 (2016). 2769324227693242
125ASCL1ARP32355_T100Vias, M. et al. Pro-neural transcription factors as cancer markers. BMC Med. Genomics 1, 17 (2008). 1848975618489756
126ASCL1ARP32355_T100Suozzi, A., Malatesta, M. & Zancanaro, C. Subcellular distribution of key enzymes of lipid metabolism during the euthermia-hibernation-arousal cycle. J. Anat. 214, 956-62 (2009). 1953863819538638
127ASGP2ARP33820_P050Chang, T.-C. et al. Synthesis and evaluation of a photoactive probe with a multivalent carbohydrate for capturing carbohydrate-lectin interactions. Bioconjug. Chem. 24, 1895-906 (2013). 2415184024151840
128ASS1ARP41366_T100Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. PLoS One. 9, e100077 (2014). 2494527924945279
129ASS1ARP41366_T100Argininosuccinate neurotoxicity and prevention by creatine in argininosuccinate lyase deficiency: An in vitro study in rat three-dimensional organotypic brain cell cultures. J Inherit Metab Dis. 42, 1077-1087 (2019) 3090700730907007
130ASS1ARP41367_T100Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 2446527724465277
131ATF4ARP37017_P050Methods for monitoring endoplasmic reticulum stress and the unfolded protein response. Int J Cell Biol. 2010, 830307 (2010). 2016913620169136
132ATF4ARP37017_P050Alger, H. M., Rayavarapu, S. & Nagaraju, K. Measurement of activation of the endoplasmic reticulum stress response in autoimmune myositis. Methods Enzymol. 489, 207-25 (2011). 2126623221266232
133ATF4ARP37017_P050Drivas, T. G., Holzbaur, E. L. F. & Bennett, J. Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration. J. Clin. Invest. 123, 4525-39 (2013). 2405137724051377
134ATF4ARP37017_P050Schneeberger, M. et al. Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance. Cell 155, 172-87 (2013). 2407486724074867
135ATF4ARP37017_P050Cross-Talk Between FSH and Endoplasmic Reticulum Stress: A Mutually Suppressive Relationship. Reprod Sci. 23, 352-64 (2016). 2634205226342052
136ATF4ARP37017_P050Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response. Antioxid. Redox Signal. 26, 247-261 (2017). 2683868026838680
137ATF4ARP37017_P050The integrated stress response in hypoxia-induced diffuse white matter injury. J Neurosci. (2017). 2872057128720571
138ATF4ARP37017_P050IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation. Oncotarget. 8, 56768-56779 (2017). 2891562928915629
139ATF4ARP37017_P050Deficiency of VCP-Interacting Membrane Selenoprotein (VIMP) Leads to G1 Cell Cycle Arrest and Cell Death in MIN6 Insulinoma Cells. Cell Physiol Biochem. 51, 2185-2197 (2018). 3053772830537728
140ATF4ARP37017_P050Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium. Front Cell Neurosci. 13, 56 (2019). 3083784430837844
141ATF4ARP37017_P050Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation. Cell Stem Cell. 25, 531-541.e6 (2019). 3158509431585094
142ATF4ARP38066_P050Kalinec, G. M. et al. Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways. Hear. Res. 313, 26-37 (2014). 2479311624793116
143ATF6ARP32293_P050Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. PLoS One. 10, e0115723 (2015). 2569525325695253
144ATG4BOAAF02774NKCT1 (purified Naja kaouthia protein toxin) conjugated gold nanoparticles induced Akt/mTOR inactivation mediated autophagic and caspase 3 activated apoptotic cell death in leukemic cell. Toxicon. 121, 86-97 (2016). 2752727027527270
145ATOH1ARP32365_P050Regenerating hair cells in vestibular sensory epithelia from humans. Elife. 7, (2018). 3001967230019672
146ATP1B1ARP44411_P050Dec1 and CLOCK Regulate Na+/K+-ATPase β1 Subunit Expression and Blood Pressure. Hypertension. 72, 746-754 (2018). 3001286830012868
147Atp1b2ARP45156_P050Li, Y.-G. et al. 1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice. Sci. Rep. 3, 1377 (2013). 2353617423536174
148Atp1b2ARP45156_P050Li, Y.-G., Ji, D.-F., Zhong, S., Lv, Z.-Q. & Lin, T.-B. Cooperative anti-diabetic effects of deoxynojirimycin-polysaccharide by inhibiting glucose absorption and modulating glucose metabolism in streptozotocin-induced diabetic mice. PLoS One 8, e65892 (2013). 2375528923755289
149ATP5BARP48185_T100Li, N., Bates, D. J., An, J., Terry, D. A. & Wang, E. Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain. Neurobiol. Aging 32, 944-55 (2011). 1948705119487051
150ATP5BARP48185_T100Bannister, J. P. et al. Ca(V)1.2 channel N-terminal splice variants modulate functional surface expression in resistance size artery smooth muscle cells. J. Biol. Chem. 286, 15058-66 (2011). 2136428421364284
151ATP5BARP48185_T100Guo, J. et al. Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria. J. Proteomics 74, 2370-9 (2011). 2180186221801862
152ATP5BARP48186_T100Rubel, C. E. et al. Diggin’ on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substrates. Cell Biochem. Biophys. 67, 127-38 (2013). 2369578223695782
153ATP5BARP48186_T100Teodoro, J. S. et al. Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation. Mitochondrion 13, 637-46 (2013). 2404146124041461
154ATP5BARP48186_T100Usui, T. et al. Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice. FEBS Lett. 588, 1935-41 (2014). 2472672324726723
155ATP5F1BARP48185_T100A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats. Sci Rep. 7, 9253 (2017). 2883567128835671
156ATP5F1BARP48185_T100Resveratrol Improves Muscle Atrophy by Modulating Mitochondrial Quality Control in STZ-Induced Diabetic Mice. Mol Nutr Food Res. 62, e1700941 (2018). 2957830129578301
157ATP5F1BARP48185_T100Antioxidant Apigenin Relieves Age-Related Muscle Atrophy by Inhibiting Oxidative Stress and Hyperactive Mitophagy and Apoptosis in Skeletal Muscle of Mice. J Gerontol A Biol Sci Med Sci. 75, 2081-2088 (2020). 3285710532857105
158AXLOAAB17122Chemotherapy confers a conserved secondary tolerance to EGFR inhibition via AXL-mediated signaling bypass. Sci Rep. 11, 8016 (2021). 3385024933850249
159B2GP1OPPA01429Effects of antibodies against human parvovirus B19 on angiogenic signaling. Mol Med Rep 2020 3 21 1320-1327 3192222031922220
160BACH2ARP39513_P050TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. Cell. 182, 297-316.e27 (2020) 3261942432619424
161B-ACTINARP40174_P050Regular exercise modulates cardiac mast cell activation in ovariectomized rats. J Physiol Sci. 66, 165-73 (2016). 2646744926467449
162BAG2ARP42177_T100BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. Elife. 4, (2015). 2627100826271008
163BASP1ARP59932_P050Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity. Front Synaptic Neurosci 2022 NULL 14 855673 3557366235573662
164BAXAVARP02020_T100Honda, A. et al. Activation of caspase 3, 9, 12, and Bax in masseter muscle of mdx mice during necrosis. J. Muscle Res. Cell Motil. 28, 243-7 (2007). 1795261817952618
165BAXAVARP02020_T100De Martino, L. et al. Bid cleavage, cytochrome c release and caspase activation in canine coronavirus-induced apoptosis. Vet. Microbiol. 141, 36-45 (2010). 1978187119781871
166BCAR1OAEB03174Platelet-derived growth factor receptor-a and Ras-related C3 botulinum toxin substrate-1 regulate mechano-responsiveness of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 313, L1174-L1187 (2017). 2877509728775097
167BCAT1ARP46132_P050Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression. EMBO J e110466 41 9 May 202235307861
168BCHEARP44208_T100Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease. Neuropathology. 36, 135-45 (2016). 2629330826293308
169BCL2OAAF00934Fibroblast growth factor 22 is a novel modulator of depression through interleukin-1β. CNS Neurosci Ther. 23, 907-916 (2017). 2894871628948716
170BCL2OAPB00242Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. Cancer Cell. 36, 250-267.e9 (2019). 3152675831526758
171BDKRB2OABF00968Pharmacological Modulation of Blood-Brain Barrier Permeability by Kinin Analogs in Normal and Pathologic Conditions. Pharmaceuticals (Basel). 13, NULL (2020). 3300341533003415
172BDNFARP41970_P050McCarthy, D. M. et al. Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain. J. Neurosci. 31, 13400-11 (2011). 2194043321940433
173BDNFARP41970_P050Horibe, I. et al. Induction of melanogenesis by 4’-O-methylated flavonoids in B16F10 melanoma cells. J. Nat. Med. 67, 705-10 (2013). 2324231023242310
174BDNFARP41970_P050TrkB/BDNF signalling patterns the sympathetic nervous system. Nat Commun. 6, 8281 (2015). 2640456526404565
175BDNFARP41970_P050Sex differences and estrogen regulation of BDNF gene expression, but not propeptide content, in the developing hippocampus. J. Neurosci. Res. 95, 345-354 (2017). 2787044427870444
176BDNFARP41970_P050Reversal Learning Deficits Associated with Increased Frontal Cortical Brain-Derived Neurotrophic Factor Tyrosine Kinase B Signaling in a Prenatal Cocaine Exposure Mouse Model. Dev. Neurosci. 38, 354-364 (2016). 2795153127951531
177BDNFARP41970_P050Prenatal Cocaine Exposure Alters BDNF-TrkB Signaling in the Embryonic and Adult Brain. Dev. Neurosci. 38, 365-374 (2016). 2813205428132054
178BDNFARP41970_P050The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression. BMC Neurosci. 20, 65 (2019). 3188351131883511
179BHMTARP41474_T100Maclean, K. N., Jiang, H., Greiner, L. S., Allen, R. H. & Stabler, S. P. Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk. Mol. Genet. Metab. 105, 395-403 (2012). 2219252422192524
180BHMTARP41474_T100Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 2446527724465277
181BHMTARP41474_T100Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap. Biol Open. 4, 1154-62 (2015). 2627610126276101
182BHMTARP41474_T100Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria. FASEB J. 33, 6339-6353 (2019) 3076835930768359
183BICC1OAAB04089Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila. PLoS Genet. 13, e1006694 (2017). 2840690228406902
184BLZF1OAAN01805A protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma. J Clin Invest. 131, (2021). 3293148332931483
185BMP7ARP32328_P050Kodama, S., Okamoto, T. & Suzuki, M. Sinonasal schwannoma with new bone formation expressing bone morphogenic protein. Int. J. Otolaryngol. 2010, 154948 (2010). 2119744121197441
186BMP7ARP32328_P050Okamoto, T., Kodama, S., Nomi, N., Umemoto, S. & Suzuki, M. Expression of bone morphogenic protein in sinonasal inverted papilloma with new bone formation. Allergy Rhinol. (Providence). 2, 16-20 (2011). 2285211022852110
187BMP7ARP32328_P050Kitamura, S. et al. The Selection of Peritoneal Mesothelial Cells Is Important for Cell Therapy to Prevent Peritoneal Fibrosis. Tissue Eng. Part A (2013). doi:10.1089/ten.TEA.2013.0130 2400742824007428
188BMP7ARP32329_T100Morrissey, C., Brown, L. G., Pitts, T. E. M., Vessella, R. L. & Corey, E. Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment. Neoplasia 12, 192-205 (2010). 2012647720126477
189BMP7ARP32329_T100Mae, S.-I. et al. Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem. Biophys. Res. Commun. 393, 877-82 (2010). 2017195220171952
190BMP7ARP32329_T100Yi, T. et al. Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression. J. Biol. Chem. 285, 17811-20 (2010). 2037501520375015
191BMP7ARP32329_T100Filion, T. M. et al. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng. Part A 17, 503-11 (2011). 2081899920818999
192BMP7ARP32329_T100Fiaschetti, G. et al. Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma. Oncogene 30, 2823-35 (2011). 2131792221317922
193BMP7ARP32329_T100Rui, Y. F. et al. Expression of chondro-osteogenic BMPs in clinical samples of patellar tendinopathy. Knee Surg. Sports Traumatol. Arthrosc. 20, 1409-17 (2012). 2194695021946950
194BMP7ARP32329_T100Lovric, V. et al. Effects of demineralized bone matrix on tendon-bone healing in an intra-articular rodent model. Am. J. Sports Med. 40, 2365-74 (2012). 2298413122984131
195BMP7ARP32329_T100Whiteland, H. et al. Putative prognostic epithelial-to-mesenchymal transition biomarkers for aggressive prostate cancer. Exp. Mol. Pathol. 95, 220-6 (2013). 2393319423933194
196BMP7ARP32329_T100A self-avoidance mechanism in patterning of the urinary collecting duct tree. BMC Dev Biol. 14, 35 (2014). 2520511525205115
197Bnc1ARP33283_P050BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency. Nat Commun 5871 13 1 October 202236198708
198BRCA1ARP33338_P050Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice. Clin Cancer Res. 20, 4086-95 (2014). 2484295324842953
199C15orf48ARP50069_P050Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network. PLoS Biol 2020 12 18 e3001045 3337027133370271
200C1qBARP44297_P050Kuramoto, A. et al. The formation of immune complexes is involved in the acute phase of periodontal destruction in rats. J. Periodontal Res. 47, 455-62 (2012). 2228374522283745
201C1qBARP44297_P050Yoshinaga, Y. et al. Topical application of lipopolysaccharide into gingival sulcus promotes periodontal destruction in rats immunized with lipopolysaccharide. J. Periodontal Res. 47, 674-80 (2012). 2258289422582894
202C1qBARP44297_P050Nagano, F. et al. Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction. J. Periodontal Res. 48, 420-7 (2013). 2313727223137272
203C1qBARP44297_P050Nakatsu, S. et al. Occlusal trauma accelerates attachment loss at the onset of experimental periodontitis in rats. J. Periodontal Res. (2013). doi:10.1111/jre.12109 2380882023808820
204C1QBARP44297_P050Histopathological comparison of the onset of peri-implantitis and periodontitis in rats. Clin Oral Implants Res. 28, 163-170 (2017). 2680413926804139
205C1QBARP44297_P050The histopathological comparison on the destruction of the periodontal tissue between normal junctional epithelium and long junctional epithelium. J. Periodont. Res. 52, 74-82 (2017). 2695723126957231
206CACNG4OASG04296Amplification of a calcium channel subunit CACNG4 increases breast cancer metastasis. EBioMedicine. 52, 102646 (2020). 3206235232062352
207CALCRLARP42260_P050Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism. iScience 104823 25 8 August 202235992092
208CALRARP30114_p050MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas. Cancer Prev Res (Phila). 2634202426342024
209CASP1ARP58983_P050Tongxinluo May Alleviate Inflammation and Improve the Stability of Atherosclerotic Plaques by Changing the Intestinal Flora. Front Pharmacol 2022 NULL 13 805266 3543193935431939
210CASP6OAAF05316Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding. J. Neurosci. Methods. 282, 20-33 (2017). 2826756528267565
211CASP6OAAF05316Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol Aging. 61, 44531 (2018). 2903108829031088
212CASPASE-3AVARP00021_T100A scaffold-free surface culture of B16F10 murine melanoma cells based on magnetic levitation. Cytotechnology. 68, 2323-2334 (2016). 2767043827670438
213CATOAAB05216Identification and antioxidant activity of synthetic peptides from phycobiliproteins of Pyropia yezoensis. Int J Mol Med. 42, 789-798 (2018). 2971777129717771
214CATOAAB05216PYP1-4 peptide from Pyropia yezoensis protects against acetaminophen-induced hepatotoxicity in HepG2 cells. Exp Ther Med. 19, 849-860 (2020). 3201024532010245
215CATSPER2ARP35455_T100Kawano, N. et al. Seminal vesicle protein SVS2 is required for sperm survival in the uterus. Proc. Natl. Acad. Sci. U. S. A. 111, 4145-50 (2014). 2459161624591616
216CAV2AVARP09020_P050Chi Sabins, N. et al. DLK1: a novel target for immunotherapeutic remodeling of the tumor blood vasculature. Mol. Ther. 21, 1958-68 (2013). 2389672623896726
217CAV3OAAB03503Pavlović, D., McLatchie, L. M. & Shattock, M. J. The rate of loss of T-tubules in cultured adult ventricular myocytes is species dependent. Exp. Physiol. 95, 518-27 (2010). 2006135420061354
218Cbln4ARP52505_P050Gupta, S. et al. Human organic cation transporter 1 is expressed in lymphoma cells and increases susceptibility to irinotecan and paclitaxel. J. Pharmacol. Exp. Ther. 341, 16-23 (2012). 2222075222220752
219CBLN4ARP52505_P050Glycosylation of Cblns attenuates their receptor binding. Brain Res. 1694, 129-139 (2018) 2978285129782851
220CBR1ARP45800_P050Lim, S. et al. Carbonyl reductase 1 is an essential regulator of skeletal muscle differentiation and regeneration. Int. J. Biochem. Cell Biol. 45, 1784-93 (2013). 2373210923732109
221CBR1ARP45800_P050Mitani, T. et al. Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells. J. Nutr. Sci. Vitaminol. (Tokyo). 60, 122-8 (2014). 2497522224975222
222CBSARP45746_T100Fernandes, V. S. et al. Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck. J. Urol. 189, 1567-73 (2013). 2306380423063804
223CBSARP45746_T100Spellman, C., Ahmed, M. M., Dubach, D. & Gardiner, K. J. Expression of trisomic proteins in Down syndrome model systems. Gene 512, 219-225 (2013). 2310382823103828
224CBSARP45746_T100Markand, S. et al. Cystathionine beta synthase expression in mouse retina. Curr. Eye Res. 38, 597-604 (2013). 2347001623470016
225CBSARP45746_T100Dahlhoff, C. et al. Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism. PLoS One 8, e57387 (2013). 2347208323472083
226CBSARP45746_T100Porteus, C. S. et al. The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio). J. Physiol. 592, 3075-88 (2014). 2475663924756639
227CBSARP45746_T100Geillinger, K. E. et al. Hepatic metabolite profiles in mice with a suboptimal selenium status. J. Nutr. Biochem. 25, 914-22 (2014). 2491704524917045
228CBSARP45746_T100Yamane, S., Kanno, T., Nakamura, H., Fujino, H. & Murayama, T. Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: Roles of l-cysteine, cystathionine beta-synthase, and K(+) channels. Eur. J. Pharmacol. 740, 112-20 (2014). 2500807325008073
229CBSARP45746_T100Dahlhoff, C. et al. Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. Mol. Metab. 3, 565-80 (2014). 2506156125061561
230CBX4ARP30002_P050Hao, L., Midic, U., Garriga, J. & Latham, K. E. Contribution of CBX4 to cumulus oophorus cell phenotype in mice and attendant effects in cumulus cell cloned embryos. Physiol. Genomics 46, 66-80 (2014). 2428025824280258
231CCDC90AARP44777_P050Mitochondrial Ca2+ Uniporter haploinsufficiency enhances long-term potentiation at hippocampal mossy fibre synapses. J Cell Sci NULL NULL NULL October 202236274588
232CCL2AVARP07046_P050Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach. Int J Mol Sci. 19, (2018). 2951897729518977
233CCND3AVARP03038_P050Discovery of Human-Similar Gene Fusions in Canine Cancers. Cancer Res. 77, 5721-5727 (2017). 2888300328883003
234CCR2OASA06081Bhangoo, S. et al. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Mol. Pain 3, 38 (2007). 1807676218076762
235CCR2OASA06081Bhangoo, S. K., Ripsch, M. S., Buchanan, D. J., Miller, R. J. & White, F. A. Increased chemokine signaling in a model of HIV1-associated peripheral neuropathy. Mol. Pain 5, 48 (2009). 1967445019674450
236CCR2OASA06081Jeon, S.-M., Sung, J.-K. & Cho, H.-J. Expression of monocyte chemoattractant protein-1 and its induction by tumor necrosis factor receptor 1 in sensory neurons in the ventral rhizotomy model of neuropathic pain. Neuroscience 190, 354-66 (2011). 2171207121712071
237CCT4ARP34271_P050Laux, A. et al. Localization of endogenous morphine-like compounds in the mouse spinal cord. J. Comp. Neurol. 520, 1547-61 (2012). 2213371522133715
238CCT4ARP34271_P050Tarkar, A. et al. DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat. Genet. 45, 995-1003 (2013). 2387263623872636
239CCT4ARP34271_P050Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis. Mol Biol Cell. 25, 1216-33 (2014). 2455476424554764
240CD117OAEE00057Expression of Luminal Progenitor Marker CD117 in the Human Breast Gland. J Histochem Cytochem. 66, 879-888 (2018). 3000428830004288
241CD206OASA05048Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis. Cell Mol Gastroenterol Hepatol. 1, 678-694 (2015). 2669317426693174
242CD3OASA11552Natalizumab-associated progressive multifocal leukoencephalopathy in a patient with multiple sclerosis: a postmortem study. J Neuropathol Exp Neurol. 72, 1043-51 (2013). 2412868024128680
243CD3OASA11552Lack of Major Histocompatibility Complex Class I Upregulation and Restrictive Infection by JC Virus Hamper Detection of Neurons by T Lymphocytes in the Central Nervous System. J Neuropathol Exp Neurol. 74, 791-803 (2015). 2611519226115192
244CD34ARP60993_P050Telocytes in the hearts of Saanen goats. Microsc Res Tech 548-554 84 3 March 202133017500
245CD3GOAAB01258A Novel CD3G Mutation in a Taiwanese Patient With Normal T Regulatory Function Presenting With the CVID Phenotype Free of Autoimmunity-Analysis of all Genotypes and Phenotypes. Front Immunol. 10, 2833 (2020). 3192111731921117
246CD40LGARP33831_P050IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle. Reproduction. 159, 503-511 (2020) 3210382032103820
247CD68OABB00472Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation. Int J Cancer. 138, 2700-12 (2016). 2677379626773796
248CD68OABB00472Cellular senescence drives age-dependent hepatic steatosis. Nat Commun. 8, 15691 (2017). 2860885028608850
249CD68OABB00472Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice. Aging Cell. 18, e12882 (2019). 3046801330468013
250CD68OABB00472A Mitochondrial Specific Antioxidant Reverses Metabolic Dysfunction and Fatty Liver Induced by Maternal Cigarette Smoke in Mice. Nutrients. 11, (2019). 3133087831330878
251CD68OABB00472FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis. JCI Insight. 5, (2020). 3210298532102985
252CD68OABB00472c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis. Nat Metab. 2, 1350-1367 (2020) 3316898133168981
253CD68OABB00472Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis. J Immunol. (2021). 3344143833441438
254CD68OABB00472Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis. J Immunol. (2021). 3187738531877385
255CDH5ARP60108_P050Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition. J Am Heart Assoc 2022 7 11 e023695 3534800635348006
256CDK2ARP30331_P050The zebrafish miR-462/miR-731 cluster is induced under hypoxic stress via hypoxia-inducible factor 1a and functions in cellular adaptations. FASEB J. 29, 4901-13 (2015). 2626547226265472
257CDKN1BOAAI00157MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity. Genes Dev. 34, 1210-1226 (2020) 3282004032820040
258CDKN1BOAEB01630Differential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cells. J Ovarian Res. 9, 71 (2016). 2779317627793176
259CDX4ARP32765_P050Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice. Development. 135, 2511-20 (2008). 1857968318579683
260CEACAM6ARP41504_T100Kobayashi, M. et al. Carcinoembryonic antigen-related cell adhesion molecules as surrogate markers for EGFR inhibitor sensitivity in human lung adenocarcinoma. Br. J. Cancer 107, 1745-53 (2012). 2309980823099808
261CEBPAARP57937_P050Borger, P. et al. Impaired translation of CCAAT/enhancer binding protein alpha mRNA in bronchial smooth muscle cells of asthmatic patients. J. Allergy Clin. Immunol. 123, 639-45 (2009). 1912186219121862
262CEBPAARP57937_P050Miglino, N., Roth, M., Tamm, M. & Borger, P. House dust mite extract downregulates C/EBPa in asthmatic bronchial smooth muscle cells. Eur. Respir. J. 38, 50-8 (2011). 2110955821109558
263CERS2ARP32609_P050Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration. J Biomed Sci. 25, 40 (2018). 2972018329720183
264CGI-58OAEB01343Skinner, J. R., Harris, L.-A. L. S., Shew, T. M., Abumrad, N. A. & Wolins, N. E. Perilipin 1 moves between the fat droplet and the endoplasmic reticulum. Adipocyte 2, 80-6 (2013). 2380540323805403
265CHCHD3ARP57040_P050QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease. Elife 2016 NULL 5 NULL 2762314727623147
266CHMLOAAF04109Li, J. et al. Proteomic-based approach for biomarkers discovery in early detection of invasive urothelial carcinoma. Proteomics. Clin. Appl. 2, 78-89 (2008). 2113678121136781
267CHST1ARP45495_T100Sulfation of O-glycans on Mucin-type Proteins From Serous Ovarian Epithelial Tumors. Mol Cell Proteomics. 20, 100150 (2021). 3455549934555499
268CHST4ARP35787_T100Carbohydrate Sulfotransferase 4 Inhibits the Progression of Hepatitis B Virus-Related Hepatocellular Carcinoma and Is a Potential Prognostic Marker in Several Tumors. Front Oncol. 10, 554331 (2020). 3317858233178582
269CK15AVARP00005_P050Celis, J. E. et al. 15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma. Mol. Cell. Proteomics 7, 1795-809 (2008). 1863259318632593
270CKAP4ARP46790_P050Clark, R. et al. Comparative genomic and proteomic analysis of cytoskeletal changes in dexamethasone-treated trabecular meshwork cells. Mol. Cell. Proteomics 12, 194-206 (2013). 2310500923105009
271CKMT2ARP41478_T100Choudhuri, A., Maitra, U. & Evans, T. Translation initiation factor eif3h targets specific transcripts to polysomes during embryogenesis. Proc. Natl. Acad. Sci. U. S. A. 110, 9818-23 (2013). 2371666723716667
272CLCN3ARP35504_T100Jensen, V. K. et al. A quantitative assay for lysosomal acidification rates in human osteoclasts. Assay Drug Dev. Technol. 9, 157-64 (2011). 2105006821050068
273CLDN1ARP33623_P050Inhibition of Single Routes of Intracellular Signaling is Not Sufficient to Neutralize the Biphasic Disturbance of a Retinal Endothelial Cell Barrier Induced by VEGF-A165. Cell Physiol Biochem 1493-1513 42 4 July 201728719888
274CLIC1ARP35045_T100Yang, J.-Y. et al. Chloride intracellular channel 1 regulates osteoblast differentiation. Bone 45, 1175-85 (2009). 1970360519703605
275CLIC5ARP35262_T100Li, F.-N. et al. Chloride intracellular channel 5 modulates adipocyte accumulation in skeletal muscle by inhibiting preadipocyte differentiation. J. Cell. Biochem. 110, 1013-21 (2010). 2056420120564201
276CLIC5ARP35263_P050The chloride intracellular channel 5A stimulates podocyte Rac1, protecting against hypertension-induced glomerular injury. Kidney Int. 89, 833-47 (2016). 2692404926924049
277CLIC5ARP35263_T100Both CLIC4 and CLIC5A activate ERM proteins in glomerular endothelium. Am. J. Physiol. Renal Physiol. 311, F945-F957 (2016). 2758210327582103
278CLUARP61142_P050Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation. J Orthop Res. (2020) 3272590432725904
279CLUHARP70642_P050Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria. Nat Commun 2022 1 13 1582 3533213335332133
280CLUHARP70642_P050CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression. Elife 2022 NULL 11 NULL 3555979435559794
281CNOT7ARP39026_P050Maragozidis, P. et al. Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker. Acta Haematol. 128, 39-46 (2012). 2261472922614729
282COL1A1OAAB10798Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome. EBioMedicine. 63, 103162 (2020). 3334099133340991
283COL1A1OAAB10798Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts. J Clin Invest. 131 (2021). 3346505133465051
284COL1A2OAAF01757Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Iα2 expression via miR-342. FASEB J. 30, 4214-4226 (2016). 2762392727623927
285COL1A2OAAF02899Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Ia2 expression via miR-342. FASEB J. 30, 4214-4226 (2016). 2762392727623927
286COL6A3OAAF02910Isolation and characterisation of a novel trophoblast side-population from first trimester placentae. Reproduction. 150, 449-62 (2015). 2624848026248480
287Collagen IOPED00033CNS fibroblasts form a fibrotic scar in response to immune cell infiltration. Nat Neurosci 2021 2 24 234-244 3352692233526922
288Collagen Type IOAMA03716Novel high-throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors. PLoS One. 13, e0207872 (2018). 3048533930485339
289Collagen Type IOAMA03716GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1. PLoS One. 15, e0228195 (2020). 3205363132053631
290COX15ARP46442_T100Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes. J. Biol. Chem. 291, 10411-25 (2016). 2694087326940873
291COX4I1ARP42784_T100Snyder, A. M. et al. Mitochondrial ferritin in the substantia nigra in restless legs syndrome. J. Neuropathol. Exp. Neurol. 68, 1193-9 (2009). 1981619819816198
292COX4l1ARP42784_T100Geerling, J. J. et al. Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice. Diabetes 63, 880-91 (2014). 2427098424270984
293CPRARP44362_P050Lee, J. W., Kim, Y. H., Yoon, S. & Lee, S. K. Cytochrome P450 system expression and DNA adduct formation in the liver of Zacco platypus following waterborne Benzo(a)pyrene exposure: implications for biomarker determination. Environ. Toxicol. (2012). doi:10.1002/tox.21833 2319295323192953
294CPT1ARP44796_P050Laghezza, A. et al. New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor a/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression. J. Med. Chem. 56, 60-72 (2013). 2317104523171045
295CPT1AARP44796_P050The contribution of the citrate pathway to oxidative stress in Down syndrome. Immunology. 149, 423-431 (2016). 2750274127502741
296CPT1AARP44796_P050New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity. Eur J Med Chem. 127, 379-397 (2017). 2807682728076827
297CPT1AARP44796_P050Silibinin improves nonalcoholic fatty liver by regulating the expression of miR‑122: An in vitro and in vivo study. Mol Med Rep. 23 (2021) 3376018933760189
298CPT1AARP44796_P050The role of CD36-Fabp4-PPARγ in skeletal muscle involves insulin resistance in intrauterine growth retardation mice with catch-up growth. BMC Endocr Disord. 22, 10 (2022). 3498349534983495
299CPT1BARP46444_P050Wolf-Johnston, A. S. et al. Alterations in the non-neuronal acetylcholine synthesis and release machinery in esophageal epithelium. Life Sci. 91, 1065-9 (2012). 2256929722569297
300CPT1BARP46444_P050Effects of neonatal dexamethasone administration on cardiac recovery ability under ischemia-reperfusion in 24-wk-old rats. Pediatr. Res. 80, 128-35 (2016). 2699126426991264
301CPT1BARP46444_P050Enhancement of Glucose Metabolism via PGC-1a Participates in the Cardioprotection of Chronic Intermittent Hypobaric Hypoxia. Front Physiol. 7, 219 (2016). 2737549727375497
302CPT2OAAN00972Reduced mitochondrial translation prevents diet-induced metabolic dysfunction but not inflammation. Aging (Albany NY). 12, 19677-19700 (2020). 3302405633024056
303CPT2OAAN00972A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv. 7, eabi7514 (2021). 3455955834559558
304CREB3L2ARP34673_T100Sievert, A. J. et al. Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene. Brain Pathol. 19, 449-58 (2009). 1901674319016743
305CREB3L2ARP34673_T100Fox, R. M., Hanlon, C. D. & Andrew, D. J. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. J. Cell Biol. 191, 479-92 (2010). 2104144321041443
306CREB3L2ARP34673_T100Lynch, J. M. et al. A thrombospondin-dependent pathway for a protective ER stress response. Cell 149, 1257-68 (2012). 2268224822682248
307CREB3L2ARP34673_T100CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells. J Cell Sci. 130, 4155-4167 (2017). 2909302329093023
308CREBBPARP43609_P050p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. Cancers (Basel). 13 (2021). 3379941833799418
309CREBBPARP43609_P050p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. Cancers (Basel). 13 (2021). 3488499234884992
310CRHR1OASG01837Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function. JCI Insight. 3, (2018). 3028282130282821
311CRHR1OASG01837Orexin A Enhances Pro-Opiomelanocortin Transcription Regulated by BMP-4 in Mouse Corticotrope AtT20 Cells. Int J Mol Sci. 22 (2021) 3392536833925368
312CRY1ARP59758_P050Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles. Proc. Natl. Acad. Sci. U.S.A. 113, 6053-8 (2016). 2716642327166423
313CRY2ARP52398_P050Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles. Proc. Natl. Acad. Sci. U.S.A. 113, 6053-8 (2016). 2716642327166423
314CSEARP31932_P050Fernandes, V. S. et al. Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck. J. Urol. 189, 1567-73 (2013). 2306380423063804
315CSF1ROAAB18690Inhaled Seralutinib Exhibits Potent Efficacy in Models of Pulmonary Arterial Hypertension. Eur Respir J 2022 NULL NULL NULL 3568014435680144
316CSN1S1OAAB03556Pick, E. et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS One 7, e43980 (2012). 2295699622956996
317CSN2ARP38431_T100Pick, E. et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS One 7, e43980 (2012). 2295699622956996
318CSN8ARP52242_P050Pick, E. et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS One 7, e43980 (2012). 2295699622956996
319CXCL12OAAB09710de Paz, J. L. et al. Profiling heparin-chemokine interactions using synthetic tools. ACS Chem. Biol. 2, 735-44 (2007). 1803099018030990
320CXCL14AVARP07023_P050Takahashi, M. et al. CXCL14 enhances insulin-dependent glucose uptake in adipocytes and is related to high-fat diet-induced obesity. Biochem. Biophys. Res. Commun. 364, 1037-42 (2007). 1797130417971304
321CXCL14AVARP07023_P050Lietz, R. et al. Codelivery of the chemokine CCL3 by an adenovirus-based vaccine improves protection from retrovirus infection. J. Virol. 86, 1706-16 (2012). 2209014222090142
322CXCL14AVARP07023_P050Perrone, C. E. et al. Genomic and metabolic responses to methionine-restricted and methionine-restricted, cysteine-supplemented diets in Fischer 344 rat inguinal adipose tissue, liver and quadriceps muscle. J. Nutrigenet. Nutrigenomics 5, 132-57 (2012). 2305209723052097
323CXCL9OAAB02538Markosyan, N. et al. Mammary Carcinoma Cell Derived Cyclooxygenase 2 Suppresses Tumor Immune Surveillance by Enhancing Intratumoral Immune Checkpoint Activity. Breast Cancer Res. 15, R75 (2013). 2400481924004819
324CXCR4ARP30799_P050Biopolymer-delivered vascular endothelial growth factor improves renal outcomes following revascularization. Am J Physiol Renal Physiol. 316, F1016-F1025 (2019). 3089293330892933
325CYBBOABB00620Different signalling in infarcted and non-infarcted areas of rat failing hearts: A role of necroptosis and inflammation. J Cell Mol Med. 23, 6429-6441 (2019). 3132838131328381
326CYP19A1OASA02666Tezak, B., I. Romero, S. Milton and J. Wyneken. Identifying Sex of Neonate Turtles with Temperature-dependent Sex Determination via Small Blood Samples. Sci Rep. 2020; 10: 5012. 3219346432193464
327CYP21A2ARP60144_P050Pregnancy-associated changes of peroxisome proliferator-activated receptor delta (PPARD) and cytochrome P450 family 21 subfamily A member 2 (CYP21A2) expression in the bovine corpus luteum. J Reprod Dev. 66, 205-213 (2020). 3203737532037375
328CYP24A1OABB02030Hiroki Maruyama, et al. Low bone mineral density due to secondary hyperparathyroidism in the GlatmTg(CAG-A4GALT) mouse model of Fabry disease. 365-381 (2020). 3261752232617522
329CYP26B1ARP57351_P050Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism. iScience 104823 25 8 August 202235992092
330DAGLAOAEB01139Phosphoproteomic Analysis of Subcutaneous and Omental Adipose Tissue Reveals Increased Lipid Turnover in Dairy Cows Supplemented with Conjugated Linoleic Acid. Int J Mol Sci. 22 (2021). 3381007033810070
331DAZAP1ARP41161_P050Hayakawa, H. et al. Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress. Biochem. Biophys. Res. Commun. 403, 220-4 (2010). 2107386221073862
332DBPARP31587_P050Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction. J. Biol. Chem. 291, 4913-27 (2016). 2672845726728457
333DBPARP31587_P050Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts b-cell Function. EBioMedicine. (2017). 2838921528389215
334DBPARP32195_P050Nakabayashi, H. et al. Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1beta gene expression in pancreatic islet beta-cells. Biochem. Biophys. Res. Commun. 434, 370-5 (2013). 2356797223567972
335DBPARP32195_P050Okazaki, H. et al. Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma. Cancer Res. 74, 543-51 (2014). 2425337724253377
336DBPARP32195_P050Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats. Neurotox Res. 35, 421-431 (2019). 3032858530328585
337DCST1ARP43421_P050Dong, R. et al. Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures. Cell. Immunol. 272, 1-10 (2011). 2203047122030471
338DDIT3ARP31591_P050Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo. Cells 2021 4 10 NULL 3380805533808055
339DEKOAAB05777Clawson, G. A., Bui, V., Xin, P., Wang, N. & Pan, W. Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins. J. Cell. Biochem. 105, 81-8 (2008). 1845216018452160
340DEKOAAB05777Privette Vinnedge, L. M. et al. The human DEK oncogene stimulates beta-catenin signaling, invasion and mammosphere formation in breast cancer. Oncogene 30, 2741-52 (2011). 2131793121317931
341DGCR8ARP40984_P050Kye, M. J. et al. NMDA mediated contextual conditioning changes miRNA expression. PLoS One 6, e24682 (2011). 2193181121931811
342DGCR8ARP40984_P050Van Duyne, R. et al. Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery. PLoS One 7, e40662 (2012). 2280822822808228
343DGCR8ARP40984_P050DGCR8 is essential for tumor progression following PTEN loss in the prostate. EMBO Rep. 16, 1219-32 (2015). 2620671826206718
344DHX34ARP36417_P050Histamine receptors mediate contraction of reticular groove smooth muscle of adult goats. Anat Histol Embryol 440-450 49 4 July 202032128873
345DHX9ARP36343_P050Kawai, S. & Amano, A. BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex. J. Cell Biol. 197, 201-8 (2012). 2249272322492723
346DLL1ARP46625_P050Suprynowicz, F. A. et al. Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 109, 20035-40 (2012). 2316965323169653
347DLL1ARP46625_P050Caliceti, C. et al. 17beta-estradiol enhances signalling mediated by VEGF-A-delta-like ligand 4-notch1 axis in human endothelial cells. PLoS One 8, e71440 (2013). 2396721023967210
348DMBT1ARP42352_P050Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis. Glycobiology 2021 8 31 1026-1036 3375511333755113
349DMP-1ARP34602_P050Tooth Germ-Like Construct Transplantation for Whole-Tooth Regeneration: An In Vivo Study in the Miniature Pig. Artif Organs. 40, E39-50 (2016). 2658265126582651
350DNM1LARP52329_P050Su, Y. C., Chiu, H. W., Hung, J. C. & Hong, J. R. Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting. Apoptosis 19, 1457-70 (2014). 2500879025008790
351DPP10OAAB05596Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma. Dis Model Mech. 11, (2018). 2936151329361513
352DPP4ARP63319_P050Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma. Oncol Rep. 31, 2820-6 (2014). 2478959224789592
353DSCAMARP45086_P050DSCAM is differentially patterned along the optic axon pathway in the developing Xenopus visual system and guides axon termination at the target. Neural Dev 2022 1 17 5 3542201335422013
354DSG2ARP45198_P050Hummitzsch, K. et al. A new model of development of the mammalian ovary and follicles. PLoS One 8, e55578 (2013). 2340900223409002
355DTX1OAGA00965Glycogen synthase kinase 3β inhibition enhances Notch1 recycling. Mol Biol Cell. 29, 389-395 (2018). 2923781629237816
356DTX1OAGA00965PI5P4Kγ functions in DTX1-mediated Notch signaling. Proc Natl Acad Sci U S A. 115, E1983-E1990 (2018). 2944043229440432
357EAAT2ARP33840_P050Pretto, D. I. et al. Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome. Neurobiol. Aging 35, 1189-97 (2014). 2433244924332449
358EDAOAAB03423a de novo 3.8-Mb inversion affecting the EDA and XIST genes in a heterozygous female calf with generalized hypohidrotic ectodermal dysplasia. BMC Genomics. 20, 715 (2019). 3153362431533624
359EDEM1ARP47054_P050ERADication of EDEM1 occurs by selective autophagy and requires deglycosylation by cytoplasmic peptide N-glycanase. Histochem Cell Biol 2014 2 142 153-69 2466442524664425
360EDF1ARP37729_T100Vitamin D Prevents High Glucose-Induced Lipid Droplets Accumulation in Cultured Endothelial Cells: The Role of Thioredoxin Interacting Protein. Biomedicines 2021 12 9 NULL 3494469034944690
361EEA1ARP30074_P050Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells. EMBO Rep. 17, 1753-1765 (2016). 2786112427861124
362EEF2ARP58457_P050Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2. Mol Cell. 74, 88-100.e9 (2019). 3087680430876804
363EFNB3OAAF01784Estrogen and testosterone in concert with EFNB3 regulate vascular smooth muscle cell contractility and blood pressure. Am J Physiol Heart Circ Physiol. 310, H861-72 (2016). 2685124626851246
364EGR1ARP32241_P050Barbolina, M. V, Adley, B. P., Ariztia, E. V, Liu, Y. & Stack, M. S. Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression. J. Biol. Chem. 282, 4924-31 (2007). 1715888517158885
365EGR1ARP32241_P050Wenzel, K. et al. Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway. Biol. Chem. 388, 489-95 (2007). 1751684417516844
366EGR1ARP32241_P050Jaluria, P., Konstantopoulos, K., Betenbaugh, M. & Shiloach, J. Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates. Biotechnol. Bioeng. 99, 1443-52 (2008). 1802305018023050
367EGR1ARP32241_P050Tennis, M. A. et al. Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1. Neoplasia 12, 244-53 (2010). 2036870720368707
368EGR1ARP32241_P050Lane, K. R. et al. Cell cycle-regulated protein abundance changes in synchronously proliferating HeLa cells include regulation of pre-mRNA splicing proteins. PLoS One 8, e58456 (2013). 2352051223520512
369EGR1ARP32241_P050Ohata, Y. et al. Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice. J. Bone Miner. Res. 29, 1627-38 (2014). 2447010324470103
370EGR1ARP32241_P050Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve. PLoS ONE. 11, e0153256 (2016). 2705895327058953
371EGR2P100880_P050Latasa, M.-J., Ituero, M., Moran-Gonzalez, A., Aranda, A. & Cosgaya, J. M. Retinoic acid regulates myelin formation in the peripheral nervous system. Glia 58, 1451-64 (2010). 2064863820648638
372EGR2P100880_P050Lagrange, B. et al. A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages. Biochim. Biophys. Acta 1833, 1936-46 (2013). 2360296923602969
373EGR2P100880_P050Damm, F. et al. Acquired initiating mutations in early hematopoietic cells of CLL patients. Cancer Discov. 4, 1088-101 (2014). 2492006324920063
374EHFARP40136_P050He, J. et al. Profile of Ets gene expression in human breast carcinoma. Cancer Biol. Ther. 6, 76-82 (2007). 1717282117172821
375EIF2AARP41041_T100Xu, Y.-X., Liu, L., Caffaro, C. E. & Hirschberg, C. B. Inhibition of Golgi apparatus glycosylation causes endoplasmic reticulum stress and decreased protein synthesis. J. Biol. Chem. 285, 24600-8 (2010). 2052987120529871
376EIF2AK4OABF01173Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. J Neurochem. 151, 764-776 (2019). 3153945231539452
377EIF3MARP48293_T100Cheshenko, N., Trepanier, J. B., Segarra, T. J., Fuller, A. O. & Herold, B. C. HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target. PLoS One 5, e11829 (2010). 2067640720676407
378ELF3ARP36846_P050Namiki, T., Valencia, J. C., Hall, M. D. & Hearing, V. J. A novel approach to enhance antibody sensitivity and specificity by peptide cross-linking. Anal. Biochem. 383, 265-9 (2008). 1880133018801330
379ELOVL6ARP64566_P050Transcriptional regulation of bovine elongation of very long chain fatty acids protein 6 in lipid metabolism and adipocyte proliferation. J Cell Biochem 13932-13943 120 8 August 201930945346
380EMC6OACA03845Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry. Nat Commun. 11, 1127 (2020). 3211184132111841
381EMG1ARP40636_P050Armistead, J. et al. Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. Am. J. Hum. Genet. 84, 728-39 (2009). 1946398219463982
382ENO1ARP34376_T100Rambaruth, N. D. S., Greenwell, P. & Dwek, M. V. The lectin Helix pomatia agglutinin recognizes O-GlcNAc containing glycoproteins in human breast cancer. Glycobiology 22, 839-48 (2012). 2232201122322011
383ENO1ARP34377_P050Boraldi, F. et al. Hypoxia influences the cellular cross-talk of human dermal fibroblasts. A proteomic approach. Biochim. Biophys. Acta 1774, 1402-13 (2007). 1790492117904921
384ENO1ARP34377_P050Sørensen, B. S. et al. Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics. Radiother. Oncol. 92, 443-9 (2009). 1954137819541378
385ENO1ARP34377_P050Deng, M. Y. et al. Frontal-subcortical protein expression following prenatal exposure to maternal inflammation. PLoS One 6, e16638 (2011). 2134736221347362
386ENO1ARP34377_P050Kitahashi, T., Yoshimoto, M. & Imai, T. Novel immunohistochemical marker, integrin a(V)beta(3), for BOP-induced early lesions in hamster pancreatic ductal carcinogenesis. Oncol. Lett. 2, 229-234 (2011). 2286606922866069
387ENO1ARP34377_P050Braceland, M. et al. Serum enolase: a non-destructive biomarker of white skeletal myopathy during pancreas disease (PD) in Atlantic salmon Salmo salar L. J. Fish Dis. doi:10.1111/jfd.12296 (2014). 2516810625168106
388ENO3ARP48203_T100Chaika, N. V et al. Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma. PLoS One 7, e32996 (2012). 2241296822412968
389ENPP1OAEB02445de la Croix Ndong, J. et al. Asfotase-a improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1. Nat. Med. 20, 904-10 (2014). 2499760924997609
390EP300OAAF01891Differential Kat3 Usage Orchestrates the Integration of Cellular Metabolism with Differentiation. Cancers (Basel). 13 (2021). 3488499234884992
391EPAS1ARP32253_P050Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult. J Physiol 2016 5 594 1327-40 2657416226574162
392EPAS1ARP32253_P050HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. Nat Commun 2020 1 11 4111 3280777632807776
393EPB41L3OAGA01718Tumor-derived Autoantibodies Identify Malignant Pulmonary Nodules. Am J Respir Crit Care Med. 199, 1257-1266 (2019). 3042266930422669
394EPHRIN B1OAAF00520Activating Mutations in PIK3CA Lead to Widespread Modulation of the Tyrosine Phosphoproteome. J. Proteome Res. 14, 3882-91 (2015). 2626751726267517
395ERP29ARP44820_P050Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation. Nat Commun. 8, 14151 (2017). 2821824228218242
396Esr2ARP37039_P050The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming. Nucleic Acids Res 2021 11 49 6144-6164 3409659334096593
397ESRRGARP31655_T100Song, G. & Wang, L. Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma. Nucleic Acids Res. 36, 5727-35 (2008). 1877621918776219
398ESRRGARP31655_T100Song, G. & Wang, L. A conserved gene structure and expression regulation of miR-433 and miR-127 in mammals. PLoS One 4, e7829 (2009). 1994663619946636
399ETS1P100604_T100ETS1 induction by the microenvironment promotes ovarian cancer metastasis through focal adhesion kinase. Cancer Lett. 414, 190-204 (2018). 2917480029174800
400ETS2OAAB06446Yoshimatsu, Y. et al. Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. J. Cell Sci. 124, 2753-62 (2011). 2180794021807940
401EXT2ARP44277_P050Oocyte Cytoplasmic Gas6 and Heparan Sulfate (HS) are Required to Establish the Open Chromatin State in Nuclei During Remodeling and Reprogramming. Cell Physiol Biochem. 45, 37-53 (2018). 2931655329316553
402EYA1ARP32434_P050The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis. Dev Cell. 33, 22-35 (2015). 2581698725816987
403F2ARP41757_P050Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling. Am J Pathol 2022 2 192 361-378 3514476235144762
404Fa2hARP33121_P050Effects of Environmental Heat Load on Endocannabinoid System Components in Adipose Tissue of High Yielding Dairy Cows. Animals (Basel) NULL 12 6 March 202235327191
405FABP3ARP33823_T100Chen, H.-M., Zheng, C.-X., Gao, Q., Ge, Y.-C. & Liu, Z.-H. Heart-type fatty acid binding protein is associated with proteinuria in obesity. PLoS One 7, e45691 (2012). 2302918323029183
406FAHARP41681_T100Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 2446527724465277
407FAHARP41681_T100Functional and Biochemical Characterization of Hepatitis C Virus (HCV) Particles Produced in a Humanized Liver Mouse Model. J. Biol. Chem. 290, 23173-87 (2015). 2622463326224633
408FAM123BOAAB03558Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer. Clin Cancer Res. 21, 4709-18 (2015). 2607148326071483
409FAM20AOACD03385Lack of FAM20A, Ectopic Gingival Mineralization and Chondro/Osteogenic Modifications in Enamel Renal Syndrome. Front Cell Dev Biol. 8, 605084 (2021). 3342591033425910
410FAM20AOACD03385Pathogenesis of Enamel-Renal Syndrome Associated Gingival Fibromatosis: A Proteomic Approach. Front Endocrinol (Lausanne). 12, 752568 (2021). 3477724834777248
411FAM20AOACD03385Enamel and dentin in Enamel renal syndrome: A confocal Raman microscopy view. Front Physiol 957110 13 NULL September 202236091358
412FAM20COAAB01003Lack of FAM20A, Ectopic Gingival Mineralization and Chondro/Osteogenic Modifications in Enamel Renal Syndrome. Front Cell Dev Biol. 8, 605084 (2021). 3342591033425910
413FAM20COAAB01003Enamel and dentin in Enamel renal syndrome: A confocal Raman microscopy view. Front Physiol 957110 13 NULL September 202236091358
414FAM40BOAAB02551Carbonic Anhydrase 8 Expression in Purkinje Cells Is Controlled by PKCγ Activity and Regulates Purkinje Cell Dendritic Growth. Mol Neurobiol 2016 8 53 5149-60 2639964126399641
415FASTKOAAB08734Bauer, A. et al. Identification of malignancy factors by analyzing cystic tumors of the pancreas. Pancreatology 9, 34-44 (2009). 1907745319077453
416FBLARP40366_T100Ernoult-Lange, M. et al. Nucleocytoplasmic traffic of CPEB1 and accumulation in Crm1 nucleolar bodies. Mol. Biol. Cell 20, 176-87 (2009). 1892313718923137
417FBLARP40366_T100Armistead, J. et al. Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. Am. J. Hum. Genet. 84, 728-39 (2009). 1946398219463982
418FBP1ARP41406_T100Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 2446527724465277
419FBXL2OAAB02444Crystal structure and interaction studies of the human FBxo3 ApaG domain. FEBS J. 283, 2091-101 (2016). 2701086627010866
420FBXO7ARP43128_P050The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway. Biochim Biophys Acta Gen Subj 2021 1 1865 129754 3301035233010352
421Fbxw7ARP37443_P050Huang, H. et al. NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. Oncotarget 5, 493-505 (2014). 2445782724457827
422FBXW7ARP47419_P050Gong, Y. et al. Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. Nat. Genet. 46, 588-94 (2014). 2479313624793136
423FBXW7ARP47419_P050FBXW7 mediates high glucose‑induced SREBP‑1 expression in renal tubular cells of diabetic nephropathy under PI3K/Akt pathway regulation. Mol Med Rep. 23 (2021). 3353781233537812
424FECHARP41682_T100Susceptibility to 5-aminolevulinic acid based photodynamic therapy in WHO I meningioma cells corresponds to ferrochelatase activity. Photochem Photobiol 235-41 87 1 November 201021073472
425FGF2ARP42005_P050MicroRNA-205 mediates endothelial progenitor functions in distraction osteogenesis by targeting the transcription regulator NOTCH2. Stem Cell Res Ther. 12, 101 (2021). 3353605833536058
426FGF2OPPA00628The garlic-derived organosulfur compound diallyl trisulphide suppresses tissue factor function. Food Funct 2022 3 13 1246-1255 3502263535022635
427FGF22OAAF02973Fibroblast growth factor 22 is a novel modulator of depression through interleukin-1β. CNS Neurosci Ther. 23, 907-916 (2017). 2894871628948716
428FGFR1OAAB11171Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation. Haematologica. 105, 1262-1273 (2020). 3143967331439673
429FGFR3OAAB11172Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling. Oncotarget. 9, 34306-34319 (2018). 3034494430344944
430FHL1ARP34378_T100Windpassinger, C. et al. An X-linked myopathy with postural muscle atrophy and generalized hypertrophy, termed XMPMA, is caused by mutations in FHL1. Am. J. Hum. Genet. 82, 88-99 (2008). 1817988818179888
431FHL1ARP34378_T100Quinzii, C. M. et al. X-linked dominant scapuloperoneal myopathy is due to a mutation in the gene encoding four-and-a-half-LIM protein 1. Am. J. Hum. Genet. 82, 208-13 (2008). 1817990118179901
432FHL1ARP34378_T100Schoser, B. et al. Consequences of mutations within the C terminus of the FHL1 gene. Neurology 73, 543-51 (2009). 1968745519687455
433FHL1ARP34378_T100Gueneau, L. et al. Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy. Am. J. Hum. Genet. 85, 338-53 (2009). 1971611219716112
434FHL1ARP34378_T100Sharma, P., Shathasivam, T., Ignatchenko, V., Kislinger, T. & Gramolini, A. O. Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein-protein interaction analysis. Mol. Biosyst. 7, 1185-96 (2011). 2124611621246116
435FHL1ARP34378_T100Dong, R. et al. Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures. Cell. Immunol. 272, 1-10 (2011). 2205319422053194
436FHL1ARP34378_T100Koike, K. et al. High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer. Int. J. Oncol. 42, 141-50 (2013). 2312376623123766
437FHL1ARP34378_T100Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Hum Mol Genet. 23, 209-25 (2014). 2397567923975679
438FHL1ARP34378_T100Fujii, T. et al. A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles. J. Neurol. Sci. 343, 206-10 (2014). 2492807824928078
439FHL1ARP34378_T100Fhl1 W122S causes loss of protein function and late-onset mild myopathy. Hum Mol Genet. 24, 714-26 (2015). 2527477625274776
440FHL1ARP34378_T100Exome Sequencing Identified a Splice Site Mutation in FHL1 that Causes Uruguay Syndrome, an X-Linked Disorder With Skeletal Muscle Hypertrophy and Premature Cardiac Death. Circ Cardiovasc Genet. 9, 130-5 (2016). 2693303826933038
441FHL1ARP34378_T100Immunohistochemistry on a panel of Emery-Dreifuss muscular dystrophy samples reveals nuclear envelope proteins as inconsistent markers for pathology. Neuromuscul. Disord. 27, 338-351 (2017). 2821426928214269
442FHL1ARP34378_T100Cardiomyopathy and altered integrin-actin signaling in Fhl1 mutant female mice. Hum Mol Genet. 28, 209-219 (2019). 3026039430260394
443FHL2ARP34506_T100Han, W. et al. FHL2 interacts with and acts as a functional repressor of Id2 in human neuroblastoma cells. Nucleic Acids Res. 37, 3996-4009 (2009). 1941706819417068
444FHL2ARP34506_T100Saeki, Y. et al. Ligand-specific sequential regulation of transcription factors for differentiation of MCF-7 cells. BMC Genomics 10, 545 (2009). 1992568219925682
445FMO3ARP44434_P050Vascular reactivity stimulated by TMA and TMAO: Are perivascular adipose tissue and endothelium involved? Pharmacol Res 2021 NULL 163 105273 3319759933197599
446FOLH1OAAB10007Walder, K. K. et al. Immunohistological and electrophysiological evidence that N-acetylaspartylglutamate is a co-transmitter at the vertebrate neuromuscular junction. Eur. J. Neurosci. 37, 118-29 (2013). 2313447623134476
447FOLR1ARP41427_P050Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation. Nat Commun. 12, 3362 (2021). 3409969234099692
448FOSL1ARP31377_P050Yang, L. et al. Biological function and prognostic significance of peroxisome proliferator-activated receptor d in rectal cancer. Clin. Cancer Res. 17, 3760-70 (2011). 2149922721499227
449FOSL1ARP31377_P050Seitz, O., Schürmann, C., Pfeilschifter, J., Frank, S. & Sader, R. Identification of the Fra-1 transcription factor in healing skin flaps transplants: a potential role as a negative regulator of VEGF release from keratinocytes. J. Craniomaxillofac. Surg. 40, 379-86 (2012). 2184072721840727
450FOXA3ARP31945_P050Menga, A. et al. Insight into mechanism of in vitro insulin secretion increase induced by antipsychotic clozapine: role of FOXA1 and mitochondrial citrate carrier. Eur. Neuropsychopharmacol. 23, 978-87 (2013). 2295965422959654
451FOXD1OAAB10686FOXD1 and Gal-3 Form a Positive Regulatory Loop to Regulate Lung Cancer Aggressiveness. Cancers (Basel). 11, (2019). 3179521331795213
452FOXF1ARP32296_T100Lo, P.-K. et al. Cytoplasmic mislocalization of overexpressed FOXF1 is associated with the malignancy and metastasis of colorectal adenocarcinomas. Exp. Mol. Pathol. 94, 262-9 (2013). 2310361123103611
453FOXF1ARP32296_T100Tamura, M. et al. Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness. Oncogene (2013). doi:10.1038/onc.2013.427 2418619924186199
454FOXF2ARP31694_T100The dual role of FOXF2 in regulation of DNA replication and the epithelial-mesenchymal transition in breast cancer progression. Cell. Signal. 28, 1502-19 (2016). 2737796327377963
455FOXK2ARP34775_P050Komorek, J. et al. Adenovirus type 5 E1A and E6 proteins of low-risk cutaneous beta-human papillomaviruses suppress cell transformation through interaction with FOXK1/K2 transcription factors. J. Virol. 84, 2719-31 (2010). 2005374620053746
456Foxl2ARP39574_P050The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming. Nucleic Acids Res 2021 11 49 6144-6164 3409659334096593
457FOXO3ARP38041_P050Foxo3a aggravates inflammation and induces apoptosis in IL-1-treated rabbit chondrocytes via positively regulating tenascin-c. Folia Histochem Cytobiol 2020 1 58 1-8 3200344132003441
458FOXP1ARP32564_T100Jepsen, K., Gleiberman, A. S., Shi, C., Simon, D. I. & Rosenfeld, M. G. Cooperative regulation in development by SMRT and FOXP1. Genes Dev. 22, 740-5 (2008). 1834709318347093
459FOXP1ARP32564_T100Konstantoulas, C. J., Parmar, M. & Li, M. FoxP1 promotes midbrain identity in embryonic stem cell-derived dopamine neurons by regulating Pitx3. J. Neurochem. 113, 836-47 (2010). 2017587720175877
460FOXP1ARP32564_T100Tang, B. et al. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease. Hum. Mol. Genet. 21, 3097-111 (2012). 2249299822492998
461FOXP3ARP32743_T100Kawabata, A. et al. Naïve rat umbilical cord matrix stem cells significantly attenuate mammary tumor growth through modulation of endogenous immune responses. Cytotherapy 15, 586-97 (2013). 2347432923474329
462FOXP3OAAB01500NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal. Oncotarget. 7, 2475-95 (2016). 2667361726673617
463FPGSARP63438_P050A folylpoly-γ-glutamate synthase single nucleotide polymorphism associated with response to pemetrexed treatment combined with platinum for non-small cell lung cancer. Lung Cancer. 102, 15-20 (2016). 2798758227987582
464FTCDARP41577_P050Spellman, C., Ahmed, M. M., Dubach, D. & Gardiner, K. J. Expression of trisomic proteins in Down syndrome model systems. Gene 512, 219-225 (2013). 2310382823103828
465FTH1ARP54620_P050Potrykus, J. et al. Fungal Iron Availability during Deep Seated Candidiasis Is Defined by a Complex Interplay Involving Systemic and Local Events. PLoS Pathog. 9, e1003676 (2013). 2414661924146619
466FUBP1ARP35704_P050Milosevic, J., Bulau, P., Mortz, E. & Eickelberg, O. Subcellular fractionation of TGF-beta1-stimulated lung epithelial cells: a novel proteomic approach for identifying signaling intermediates. Proteomics 9, 1230-40 (2009). 1925328119253281
467FUBP1ARP37732_T100Far Upstream Element-Binding Protein 1 Binds the 3' Untranslated Region of PKD2 and Suppresses Its Translation. J. Am. Soc. Nephrol. 27, 2645-57 (2016). 2683936826839368
468FUNDC1ARP53281_P050FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis. Nat Commun 2021 1 12 2616 3397254833972548
469FZD4ARP41266_P050McIver, S. C. et al. A unique combination of male germ cell miRNAs coordinates gonocyte differentiation. PLoS One 7, e35553 (2012). 2253640522536405
470FZD4ARP41266_P050Gonzalez, P., Fernandez-Martos, C. M., Gonzalez-Fernandez, C., Arenas, E. & Rodriguez, F. J. Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats. PLoS One 7, e50793 (2012). 2325138523251385
471FZD4ARP41266_P050Wang, L. et al. Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae. PLoS One 8, e56025 (2013). 2340524923405249
472FZD7ARP41251_P050Ueno, K. et al. Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia 10, 697-705 (2008). 1859200818592008
473FZD7ARP41251_P050Gökmen-Polar, Y. et al. Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer. Breast Cancer Res. Treat. 127, 375-84 (2011). 2060216520602165
474FZD7ARP41251_P050Ohba, S., Lanigan, T. M. & Roessler, B. J. Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes. Osteoarthritis Cartilage 18, 1620-9 (2010). 2086876020868760
475FZD7ARP41251_P050Schmuck, R. et al. Genotypic and phenotypic characterization of side population of gastric cancer cell lines. Am. J. Pathol. 178, 1792-804 (2011). 2143545921435459
476FZD7ARP41251_P050McIver, S. C. et al. A unique combination of male germ cell miRNAs coordinates gonocyte differentiation. PLoS One 7, e35553 (2012). 2253640522536405
477FZD8OAEB02431Yin, S. et al. Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer. Mol. Cancer Ther. 12, 491-8 (2013). 2344561123445611
478FZD9ARP41253_T100Tennis, M. A. et al. Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1. Neoplasia 12, 244-53 (2010). 2023481820234818
479G3BP1ARP37713_T100Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways. Cell Rep 2022 4 39 110736 3547699535476995
480G6PCARP44224_P050Iwasa, M. et al. Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis. PLoS One 8, e70309 (2013). 2393618323936183
481G6pcARP44223_P050The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes. Nat Commun 2022 1 13 1052 3521766935217669
482GABRA5ARP34984_P050Extrasynaptic α5GABAA receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord. J Neurophysiol. 120, 2953-2974 (2018). 3025673930256739
483GABRPAVARP13034_P050Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast. Mol Hum Reprod. 26, 425-440 (2020) 3235916132359161
484GABRR2ARP35060_P050Fatemi, S. H., Folsom, T. D., Rooney, R. J. & Thuras, P. D. mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway. Transl. Psychiatry 3, e271 (2013). 2377858123778581
485GADD45BARP48346_P050Babu, E. et al. Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate. Oncogene 30, 4026-37 (2011). 2150503921505039
486GADD45BARP48346_P050Dong, R. et al. Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures. Cell. Immunol. 272, 1-10 (2011). 2204845822048458
487GADD45BARP48346_P050Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors. Alcohol. Clin. Exp. Res. 40, 263-72 (2016). 2684224526842245
488GADD45BARP48346_P050BDNF rs6265 methylation and genotype interact on risk for schizophrenia. Epigenetics. 11, 11-23 (2016). 2688973526889735
489GADD45BARP48346_P050ALK5 signaling pathway mediates neurogenesis and functional recovery after cerebral ischemia/reperfusion in rats via Gadd45b. Cell Death Dis. 10, 360 (2019). 3104358131043581
490GAGE12BOAAB07499Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma. Nat Commun. 12, 7142 (2021). 3488025134880251
491GALR2OABF00517Spexin Acts as Novel Regulator for Bile Acid Synthesis. Front Physiol. 9, 378 (2018). 2969273729692737
492GAPDHARP40175_P050Fu, Y. et al. ABCA12 Regulates ABCA1-Dependent Cholesterol Efflux from Macrophages and the Development of Atherosclerosis. Cell Metab. 18, 225-38 (2013). 2393175423931754
493GAPDHARP40175_P050Kalinec, G. M. et al. Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways. Hear. Res. 313, 26-37 (2014). 2479311624793116
494GAPDHOAAD00231Kam, A. et al. Gallic acid protects against endothelial injury by restoring the depletion of DNA methyltransferase 1 and inhibiting proteasome activities. Int. J. Cardiol. 171, 231-42 (2014). 2438854424388544
495GAPDHOAAD00231Expression of Kruppel-like factor 8 and Ki67 in lung adenocarcinoma and prognosis. Exp Ther Med. 14, 1351-1356 (2017). 2881059628810596
496GAPDHOASA03787The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5. Sci Rep. 6, 33231 (2016). 2761895927618959
497GATA2ARP31855_T100Mammoto, A. et al. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature 457, 1103-8 (2009). 1924246919242469
498GATA2ARP31855_T100Huang, Y.-J. et al. The functional IGFBP7 promoter -418G>A polymorphism and risk of head and neck cancer. Mutat. Res. 702, 32-9 (2010). 2059952120599521
499GATA2ARP31855_T100Jack, B. H. A. & Crossley, M. GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis. J. Biol. Chem. 285, 32405-14 (2010). 2070560920705609
500GATA2ARP31855_T100Fujiwara, T. et al. Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells. PLoS One 7, e40959 (2012). 2302842223028422
501GATA2ARP31855_T100Wang, F. et al. A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Res. 42, 442-57 (2014). 2404908324049083
502GATA6ARP31859_P050Kallas, A., Pook, M., Trei, A. & Maimets, T. SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate. Stem Cells Int. 2014, 298163 (2014). 2470729624707296
503GCDHARP43559_T100Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 2446527724465277
504GCLCARP54576_P050Tomasi, M. L. et al. Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice. Free Radic. Biol. Med. 68, 148-58 (2014). 2429624624296246
505GCLCARP54577_P050Bardag-Gorce, F. et al. Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. Exp. Mol. Pathol. 90, 123-30 (2011). 2103616521036165
506GCLCARP54577_P050Ramani, K., Tomasi, M. L., Yang, H., Ko, K. & Lu, S. C. Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. J. Biol. Chem. 287, 36341-55 (2012). 2294227922942279
507GCLCARP54577_P050Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism. Biomolecules. 9, (2019). 3082358730823587
508GCLCARP54577_P050Cysteine improves boar sperm quality via glutathione biosynthesis during the liquid storage. Anim Biosci 2022 2 35 166-176 3444584634445846
509GCLMARP54624_P050Ramani, K., Tomasi, M. L., Yang, H., Ko, K. & Lu, S. C. Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. J. Biol. Chem. 287, 36341-55 (2012). 2294227922942279
510GCLMARP54624_P050Tomasi, M. L. et al. Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice. Free Radic. Biol. Med. 68, 148-58 (2014). 2429624624296246
511GCM1P100836_P050Baczyk, D. et al. Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast. Cell Death Differ. 16, 719-27 (2009). 1921906819219068
512GCM1P100836_P050Sivasubramaniyam, T. et al. Where polarity meets fusion: role of Par6 in trophoblast differentiation during placental development and preeclampsia. Endocrinology 154, 1296-309 (2013). 2334119723341197
513GCM1P100836_P050Kumar, P., Luo, Y., Tudela, C., Alexander, J. M. & Mendelson, C. R. The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation. Mol. Cell. Biol. 33, 1782-96 (2013). 2343860323438603
514GCM1P100836_P050Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation. J. Biol. Chem. 290, 30152-62 (2015). 2649101326491013
515GCM1P100836_P050Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis. Cell Death Dis. 8, e2590 (2017). 2815146728151467
516GDF1OACD03794Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma. Nat Commun. 12, 7142 (2021). 3488025134880251
517GJB1ARP36600_T100Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 2446527724465277
518GLI2ARP31885_P050Histological, cellular and behavioural analyses of effects of chemotherapeutic agent cyclophosphamide in the developing cerebellum. Cell Prolif. 52, e12608 (2019). 3093225130932251
519GLI2ARP31885_T100Kim, Y. et al. Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells. Cancer Res. 67, 3583-93 (2007). 1744006917440069
520GLI2ARP31885_T100Kiprilov, E. N. et al. Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J. Cell Biol. 180, 897-904 (2008). 1833221618332216
521GLI2ARP31885_T100Kabasawa, Y. et al. Amelogenin positive cells scattered in the interstitial component of odontogenic fibromas. J. Clin. Pathol. 61, 851-5 (2008). 1834423518344235
522GLI2ARP31885_T100Omenetti, A. et al. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut 57, 1275-82 (2008). 1837547118375471
523GLI2ARP31885_T100Omenetti, A. et al. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J. Clin. Invest. 118, 3331-42 (2008). 1880248018802480
524GLI2ARP31885_T100Takanaga, H. et al. Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells. Stem Cells 27, 165-74 (2009). 1892747618927476
525GLI2ARP31885_T100Madison, B. B., McKenna, L. B., Dolson, D., Epstein, D. J. & Kaestner, K. H. FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. J. Biol. Chem. 284, 5936-44 (2009). 1904996519049965
526GLI2ARP31885_T100Wall, D. S. et al. Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J. Cell Biol. 184, 101-12 (2009). 1912465119124651
527GLI2ARP31885_T100Syn, W.-K. et al. Role for hedgehog pathway in regulating growth and function of invariant NKT cells. Eur. J. Immunol. 39, 1879-92 (2009). 1954430719544307
528GLI2ARP31885_T100Kim, J. E. et al. Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma. Mod. Pathol. 22, 1312-20 (2009). 1959332819593328
529GLI2ARP31885_T100Ho, L. et al. Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. Cancer Cell 16, 126-36 (2009). 1964722319647223
530GLI2ARP31885_T100Kim, W.-Y. et al. GSK-3 is a master regulator of neural progenitor homeostasis. Nat. Neurosci. 12, 1390-7 (2009). 1980198619801986
531GLI2ARP31885_T100Nakamura, K. et al. Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS One 5, e8824 (2010). 2009868020098680
532GLI2ARP31885_T100Youssef, K. K. et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nat. Cell Biol. 12, 299-305 (2010). 2015467920154679
533GLI2ARP31885_T100Peacock, Z. S., Cox, D. & Schmidt, B. L. Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor. Oral Oncol. 46, 387-92 (2010). 2037120520371205
534GLI2ARP31885_T100Coon, V. et al. Molecular therapy targeting Sonic hedgehog and hepatocyte growth factor signaling in a mouse model of medulloblastoma. Mol. Cancer Ther. 9, 2627-36 (2010). 2080778220807782
535GLI2ARP31885_T100Schneider, S. et al. Expression of the Sonic hedgehog pathway in squamous cell carcinoma of the skin and the mucosa of the head and neck. Head Neck 33, 244-50 (2011). 2084844620848446
536GLI2ARP31885_T100Malek, R., Matta, J., Taylor, N., Perry, M. E. & Mendrysa, S. M. The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation. PLoS One 6, e17884 (2011). 2143724521437245
537GLI2ARP31885_T100Jung, I. H., Jung, D. E., Park, Y. N., Song, S. Y. & Park, S. W. Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. PLoS One 6, e27941 (2011). 2216421922164219
538GLI2ARP31885_T100Yang, L. et al. Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus. Int. J. Biochem. Mol. Biol. 3, 46-57 (2012). 2250948022509480
539GLI2ARP31885_T100Tostar, U., Finta, C., Rahman, M. F.-U., Shimokawa, T. & Zaphiropoulos, P. G. Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant. PLoS One 7, e37761 (2012). 2266639022666390
540GLI2ARP31885_T100Bosco-Clément, G. et al. Targeting Gli transcription activation by small molecule suppresses tumor growth. Oncogene 33, 2087-97 (2014). 2368630823686308
541GLI2ARP31885_T100Li, Y. et al. Gene expression profiling reveals the heterogeneous transcriptional activity of Oct3/4 and its possible interaction with Gli2 in mouse embryonic stem cells. Genomics 102, 456-67 2412100324121003
542GLI2ARP31885_T100Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. Int J Oncol. 51, 1869-1877 (2017). 2903949129039491
543GLI2ARP31885_T100Regulation of Survivin Isoform Expression by GLI Proteins in Ovarian Cancer. Cells. 8, (2019). 3073631930736319
544GLI-2ARP31885_P050Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. PLoS ONE. 11, e0167665 (2016). 2791859527918595
545GLIS2ARP30037_P050Attanasio, M. et al. Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nat. Genet. 39, 1018-24 (2007). 1761828517618285
546GLIS2ARP30037_P050Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J. 38, (2019). 3052314730523147
547GLIS2ARP30037_P050An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis. Sci Adv. 7, eabf6063 (2021). 3470550634705506
548GLRA1OAPC00117Non-uniform changes in membrane receptors in the rat urinary bladder following outlet obstruction. Eur. J. Pharmacol. 762, 82-8 (2015). 2600453526004535
549GLS2ARP43562_T100Toriumi, K. et al. Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex. Neuropsychopharmacology 37, 1387-96 (2012). 2225789622257896
550GLS2ARP43562_T100Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 2446527724465277
551GLUD1ARP45709_P050Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues. Mol. Cell. Endocrinol. 415, 1-11 (2015). 2624191126241911
552GLUD1ARP45709_P050Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions. Neurochem. Res. 42, 92-107 (2017). 2742226327422263
553GNASARP42693_P050Masyuk, A. I. et al. Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling. Am. J. Physiol. Gastrointest. Liver Physiol. 304, G1013-24 (2013). 2357878523578785
554GNASARP42693_P050Moreno-Smith, M. et al. Biologic effects of dopamine on tumor vasculature in ovarian carcinoma. Neoplasia 15, 502-10 (2013). 2363392223633922
555GNAT3OAEB00418Immunohistochemical Analysis of Human Vallate Taste Buds. Chem Senses. 40, 655-60 (2015). 2640092426400924
556GNAT3OAEB00418The Role of 5-HT3 Receptors in Signaling from Taste Buds to Nerves. J Neurosci. 35, 15984-95 (2015). 2663147826631478
557GNAT3OAEB004185-HT3A -driven green fluorescent protein delineates gustatory fibers innervating sour-responsive taste cells: A labeled line for sour taste?. J Comp Neurol. 525, 2358-2375 (2017). 2831607828316078
558GNAT3OAEB00418Michael A Kohanski, et al. Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps. 460-469.e7 (2018). 2977850429778504
559GNAT3OAEB00418Chemical receptors of the arytenoid: A comparison of human and mouse. Laryngoscope. 130, 423-430 (2020). 3090867730908677
560GNAT3OAEB00418Expression of Bitter Taste Receptors and Solitary Chemosensory Cell Markers in the Human Sinonasal Cavity. Chem Senses. 44, 483-495 (2019). 3123175231231752
561GNAT3OAEB00418A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP. Chem Senses. 44, 663-671 (2019). 3150428931504289
562GNAT3OAEB00418Zika virus infection in chemosensory cells. J Neurovirol. 26, 371-381 (2020) 3214472732144727
563GNAT3OAEB00418Functional expression of TMEM16A in taste bud cells. J Physiol. 599, 3697-3714 (2021) 3408953234089532
564GNAT3OAEB00418Whole-Brain Mapping of the Expression Pattern of T1R2, a Subunit Specific to the Sweet Taste Receptor. Front Neuroanat. 15, 751839 (2021). 3477688134776881
565GNAT3OAEB00418Whole-Brain Mapping of the Expression Pattern of T1R2, a Subunit Specific to the Sweet Taste Receptor. Front Neuroanat. 15, 751839 (2021). 3457894034578940
566GNAT3OAEB00418METTL3-mediated m6A RNA methylation regulates dorsal lingual epithelium homeostasis. Int J Oral Sci 2022 1 14 26 3558118335581183
567GNB3OALA06860No evidence for age-related alterations in the marmoset retina. Front Neuroanat 945295 16 NULL September 202236120100
568GOT1ARP48205_P050Takeda, K., Ishida, A., Takahashi, K. & Ueda, T. Synaptic vesicles are capable of synthesizing the VGLUT substrate glutamate from a-ketoglutarate for vesicular loading. J. Neurochem. 121, 184-96 (2012). 2230950422309504
569GOT1ARP48205_P050Povlsen, J. A. et al. Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation. PLoS One 8, e64093 (2013). 2370497523704975
570GOT2ARP43518_T100Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans. Antioxidants (Basel). 10 (2021). 3457307534573075
571GOT2ARP43518_T100The day/night proteome in the murine heart. Am J Physiol Regul Integr Comp Physiol 2014 2 307 R121-37 2478999324789993
572GPC1OAMA02173Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing. Exp Gerontol 2019 NULL 126 110693 3143052131430521
573GPC3ARP37665_T100Bhave, V. S. et al. Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex. Am. J. Pathol. 183, 153-9 (2013). 2366534923665349
574GPC3ARP37665_T100Plasmodium parasite as an effective hepatocellular carcinoma antigen glypican-3 delivery vector. Oncotarget. 8, 24785-24796 (2017). 2844597328445973
575GPX3ARP41491_P050Maccarrone, G. et al. Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters. J. Psychiatr. Res. 47, 1572-80 (2013). 2396267923962679
576GPX3ARP41491_P050Methionine supply alters mammary gland antioxidant gene networks via phosphorylation of nuclear factor erythroid 2-like 2 (NFE2L2) protein in dairy cows during the periparturient period. J Dairy Sci. 101, 8505-8512 (2018). 2990880229908802
577GRHL3ARP33196_P050Yu, Z., Mannik, J., Soto, A., Lin, K. K. & Andersen, B. The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. EMBO J. 28, 1890-903 (2009). 1949483519494835
578GRHL3ARP39489_P050Sakurai, T. et al. Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training. Biochem. Biophys. Res. Commun. 416, 125-9 (2011). 2209425722094257
579GRHL3ARP39489_T100Lack of IRF6 Disrupts Human Epithelial Homeostasis by Altering Colony Morphology, Migration Pattern, and Differentiation Potential of Keratinocytes. Front Cell Dev Biol. 9, 718066 (2021) 3466058034660580
580GRIK2ARP35515_T100Funk, J. A. et al. Characterization of renal toxicity in mice administered the marine biotoxin domoic Acid. J. Am. Soc. Nephrol. 25, 1187-97 (2014). 2451114124511141
581GRK5ARP54750_P050The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5. Sci Rep. 6, 33231 (2016). 2761895927618959
582GSCARP32174_P050Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 52, 181-93 (2015). 2638617826386178
583GSSOAAB04008Ramani, K., Tomasi, M. L., Yang, H., Ko, K. & Lu, S. C. Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. J. Biol. Chem. 287, 36341-55 (2012). 2294227922942279
584GTPBP9ARP40744_P050Zhang, J., Rubio, V., Lieberman, M. W. & Shi, Z.-Z. OLA1, an Obg-like ATPase, suppresses antioxidant response via nontranscriptional mechanisms. Proc. Natl. Acad. Sci. U. S. A. 106, 15356-61 (2009). 1970640419706404
585GUCY2XOACA09780Role of uroguanylin's signalling pathway in the development of ischaemic stroke. Eur J Neurosci 3720-3737 56 1 July 202235445449
586GUSBARP44234_T100Beta-Glucuronidase Catalyzes Deconjugation and Activation of Curcumin-Glucuronide in Bone. J Nat Prod. 82, 500-509 (2019). 3079441230794412
587GUSBARP44234_T100Chemopreventive efficacy of oral curcumin: a prodrug hypothesis. FASEB J. 33, 9453-9465 (2019) 3113620331136203
588GUSBARP44234_T100Bone-Specific Metabolism of Dietary Polyphenols in Resorptive Bone Diseases. Mol Nutr Food Res. 64, e2000072 (2020) 3250680832506808
589GZMBOAAF01817Influenza A surface glycosylation and vaccine design. Proc. Natl. Acad. Sci. U.S.A. 114, 280-285 (2017). 2802822228028222
590GZMHARP42686_T100Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns. J Immunol Methods. 453, 44472 (2018). 2832286328322863
591HADHBARP48133_P050Gerin, I. et al. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J. Biol. Chem. 285, 33652-61 (2010). 2073287720732877
592HADHBARP48133_P050The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2. Arterioscler Thromb Vasc Biol. 35, 787-95 (2015). 2559312925593129
593HADHBARP48133_P050TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling. Am. J. Physiol. Heart Circ. Physiol. 311, H64-75 (2016). 2719911827199118
594HADHBARP48133_P050Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy. J Mol Cell Cardiol. 138, 304-317 (2020). 3183654331836543
595HALARP45694_T100Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). 2446527724465277
596HBCOAAI00128Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly. Nat Commun. 10, 2184 (2019). 3109771631097716
597HDAC2ARP32618_P050Mta2 promotes Tipin-dependent maintenance of replication fork integrity. Cell Cycle. 13, 2120-8 (2014). 2483047324830473
598HDAC3OAAB09604Proteomic analysis identifies NPTX1 and HIP1R as potential targets of histone deacetylase-3-mediated neurodegeneration. Exp Biol Med (Maywood). 243, 627-638 (2018). 2948657729486577
599HDAC9ARP42788_T100Milde, T. et al. HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth. Clin. Cancer Res. 16, 3240-52 (2010). 2041343320413433
600HDAC9ARP42788_T100Hang, C. T. et al. Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 466, 62-7 (2010). 2059601420596014
601HDAC9ARP42788_T100Spallotta, F. et al. Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia. J. Biol. Chem. 288, 22915-29 (2013). 2383691323836913
602HES1ARP32372_T100Tilley, A. E. et al. Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 179, 457-66 (2009). 1910630719106307
603HES1ARP32372_T100Schreck, K. C. et al. The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin. Cancer Res. 16, 6060-70 (2010). 2116925721169257
604HES1ARP32372_T100Ma, W. et al. hCLP46 regulates U937 cell proliferation via Notch signaling pathway. Biochem. Biophys. Res. Commun. 408, 84-8 (2011). 2145841221458412
605HES1ARP32372_T100Bennani-Baiti, I. M. et al. Notch signalling is off and is uncoupled from HES1 expression in Ewing’s sarcoma. J. Pathol. 225, 353-63 (2011). 2198412321984123
606HES1ARP32372_T100Asnaghi, L. et al. Notch signaling promotes growth and invasion in uveal melanoma. Clin. Cancer Res. 18, 654-65 (2012). 2222863222228632
607HES1ARP32372_T100Guiu, J. et al. Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. J. Exp. Med. 210, 71-84 (2013). 2326701223267012
608HES1ARP32372_T100Chu, Q., Liu, L. & Wang, W. Overexpression of hCLP46 enhances Notch activation and regulates cell proliferation in a cell type-dependent manner. Cell Prolif. 46, 254-62 (2013). 2369208423692084
609Hes1ARP32372_T100Ma, L. et al. Atractylenolide I-mediated Notch pathway inhibition attenuates gastric cancer stem cell traits. Biochem. Biophys. Res. Commun. 450, 353-9 (2014). 2494401824944018
610HES1ARP32372_T100Asnaghi, L. et al. Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation. PLoS One 9, e105372 (2014). 2516621125166211
611HES1ARP32372_T100Therapeutic targeting of HES1 transcriptional programs in T-ALL. Blood. 125, 2806-14 (2015). 2578468025784680
612HES1ARP32372_T100Rac1 contributes to cerebral ischemia reperfusion-induced injury in mice by regulation of Notch2. Neuroscience. 306, 100-14 (2015). 2629933926299339
613HES1ARP32372_T100Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres. Brain Pathol. 26, 713-723 (2016). 2661355626613556
614HES1ARP32372_T100CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A. Oncogene. 37, 128-138 (2018). 2889204828892048
615HES1ARP32372_T100A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal. Dis Model Mech. 12, (2019). 3091099130910991
616HEY1ARP32512_P050Rac1 contributes to cerebral ischemia reperfusion-induced injury in mice by regulation of Notch2. Neuroscience. 306, 100-14 (2015). 2629933926299339
617HEY1ARP32512_P050Nuclear Factor I Represses the Notch Effector HEY1 in Glioblastoma. Neoplasia. 20, 1023-1037 (2018). 3019571330195713
618HGFARP44317_P050Sen, B., Peng, S., Saigal, B., Williams, M. D. & Johnson, F. M. Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer. Clin. Cancer Res. 17, 514-24 (2011). 2110672521106725
619HGFARP44317_P050Williams, C. M. et al. Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays. Tissue Eng. Part A 17, 1055-68 (2011). 2112187621121876
620HGFARP44317_P050Zampell, J. C. et al. Lymphatic function is regulated by a coordinated expression of lymphangiogenic and anti-lymphangiogenic cytokines. Am. J. Physiol. Cell Physiol. 302, C392-404 (2012). 2194066221940662
621HGFARP44317_P050Ji, R. et al. The differentiation of MSCs into functional hepatocyte-like cells in a liver biomatrix scaffold and their transplantation into liver-fibrotic mice. Biomaterials 33, 8995-9008 (2012). 2298599622985996
622HGFARP44317_P050Nejak-Bowen, K., Orr, A., Bowen, W. C. & Michalopoulos, G. K. Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy. PLoS One 8, e59836 (2013). 2352727523527275
623HGFARP44317_P050Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion. PLoS One. 10, e0126859 (2015). 2597839925978399
624HIF1AARP38054_P050Organ-specific effects on glycolysis by the dioxin-activated aryl hydrocarbon receptor. PLoS One 2020 12 15 e0243842 3332088433320884
625HIPK2ARP32586_P050Choi, D. W. et al. Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. J. Biol. Chem. 283, 4682-9 (2008). 1809397218093972
626HIPK2ARP32586_P050Steinmann, S. et al. v-Myc inhibits C/EBPbeta activity by preventing C/EBPbeta-induced phosphorylation of the co-activator p300. Oncogene 28, 2446-55 (2009). 1944866919448669
627HIPK2ARP32586_P050Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminergic neurons and glia via BMP signaling. J Neurosci. 31, 13746-57 (2011). 2195723821957238
628HIPK2ARP32586_P050Heat shock modulates the subcellular localization, stability, and activity of HIPK2. Biochem. Biophys. Res. Commun. 472, 580-4 (2016). 2697225626972256
629HisOAEA00010P120 catenin potentiates constitutive E-cadherin dimerization at the plasma membrane and regulates trans binding. Curr Biol 3017-3027.e7 31 14 July 202134019823
630HK2ARP54303_P050Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth. Int J Oncol. 50, 2011-2023 (2017). 2849847528498475
631HLA-DRB5OAAB06426Molecular Characteristics of High-Dose Melphalan Associated Oral Mucositis in Patients with Multiple Myeloma: A Gene Expression Study on Human Mucosa. PLoS ONE. 12, e0169286 (2017). 2805212128052121
632HMGA2OAGA00059Decoding transcriptomic intra-tumour heterogeneity to guide personalised medicine in ovarian cancer. J Pathol 2019 3 247 305-319 3037497530374975
633HMOX1ARP45222_P050Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Hum Mol Genet 2015 15 24 4480-1 2603413326034133
634HNF-1aARP51375_P050Scheving, L. A. et al. Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice. Am. J. Physiol. Gastrointest. Liver Physiol. 306, G370-81 (2014). 2440759024407590
635hnRNP LLARP41102_T100Liu, G., Lei, L., Yu, J., Kung, S. & Xie, J. Refinement of the spectra of exon usage by combined effects of extracellular stimulus and intracellular factors. Biochim. Biophys. Acta 1839, 537-45 (2014). 2484418224844182
636HNRNPA1ARP40383_T100Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev. 23, 482-95 (2009). 1924013419240134
637hnRNPA1ARP40383_T100Li, S. et al. Identification of an aptamer targeting hnRNP A1 by tissue slide-based SELEX. J. Pathol. 218, 327-36 (2009). 1929171319291713
638hnRNPA1ARP40383_T100Gonen, N. & Assaraf, Y. G. The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1. J. Biol. Chem. 285, 33602-13 (2010). 2072448220724482
639hnRNPA1ARP40383_T100Stark, M., Bram, E. E., Akerman, M., Mandel-Gutfreund, Y. & Assaraf, Y. G. Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance. J. Biol. Chem. 286, 3741-54 (2011). 2106838921068389
640hnRNPA1ARP40383_T100Li, S. et al. Aptamer BC15 against heterogeneous nuclear ribonucleoprotein A1 has potential value in diagnosis and therapy of hepatocarcinoma. Nucleic Acid Ther. 22, 391-8 (2012). 2306200823062008
641hnRNPDARP40238_T100Kang, X., Chen, W., Kim, R. H., Kang, M. K. & Park, N.-H. Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells. Oncogene 28, 565-74 (2009). 1901563519015635
642hnRNPDARP40238_T100Subramaniam, K., Ooi, L. L. P. J. & Hui, K. M. Transcriptional down-regulation of IGFBP-3 in human hepatocellular carcinoma cells is mediated by the binding of TIA-1 to its AT-rich element in the 3’-untranslated region. Cancer Lett. 297, 259-68 (2010). 2059931820599318
643HNRNPDARP40238_T100New compound ChlA-F induces autophagy-dependent anti-cancer effect via upregulating Sestrin-2 in human bladder cancer. Cancer Lett. 436, 38-51 (2018). 3011884130118841
644HNRNPDARP40238_T100The inhibitory effect of compound ChlA-F on human bladder cancer cell invasion can be attributed to its blockage of SOX2 protein. Cell Death Differ. 27, 632-645 (2020). 3124334431243344
645hnRNPH3ARP40721_T100Larriba, M. J. et al. Novel snail1 target proteins in human colon cancer identified by proteomic analysis. PLoS One 5, e10221 (2010). 2042192620421926
646HNRNPLARP40368_P050Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell. 178, 107-121.e18 (2019). 3125191131251911
647HNRNPLARP40368_P050MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation. Nat Commun. 10, 5787 (2019). 3185758031857580
648hnRNPLLARP41102_T100Yu, J. et al. The heterogeneous nuclear ribonucleoprotein L is an essential component in the Ca2+/calmodulin-dependent protein kinase IV-regulated alternative splicing through cytidine-adenosine repeats. J. Biol. Chem. 284, 1505-13 (2009). 1901765019017650
649hnRNPLLARP41102_T100Rajan, P. et al. Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies. BMC Cell Biol. 10, 82 (2009). 1991265119912651
650hnRNPLLARP41102_T100Heyd, F. & Lynch, K. W. Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing. Mol. Cell 40, 126-37 (2010). 2093248020932480
651HNRNPMOAAN02059The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules. Mol Cell 2020 1 79 54-67.e7 3252122632521226
652HNRPA3ARP41195_T100Süss, C. et al. Rapid changes of mRNA-binding protein levels following glucose and 3-isobutyl-1-methylxanthine stimulation of insulinoma INS-1 cells. Mol. Cell. Proteomics 8, 393-408 (2009). 1885457818854578
653HNRPA3ARP41195_T100Papadopoulou, C., Patrinou-Georgoula, M. & Guialis, A. Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes. Biochim. Biophys. Acta 1804, 692-703 (2010). 1993142819931428
654HNRPABARP41036_T100Bubenik, J. L., Ladd, A. N., Gerber, C. A., Budiman, M. E. & Driscoll, D. M. Known turnover and translation regulatory RNA-binding proteins interact with the 3’ UTR of SECIS-binding protein 2. RNA Biol. 6, 73-83 (2009). 1910661919106619
655HNRPABARP41036_T100Taga, Y., Miyoshi, M., Okajima, T., Matsuda, T. & Nadano, D. Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland. Cell Biochem. Funct. 28, 321-8 (2010). 2051789720517897
656HNRPFARP40565_T100White, R. et al. Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesis. J. Biol. Chem. 287, 1742-54 (2012). 2212815322128153
657HNRPH1ARP58479_P050Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell 2019 1 178 107-121.e18 3125191131251911
658HOXA10P100767_T100Ko, S. Y., Lengyel, E. & Naora, H. The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions. Mol. Cell. Endocrinol. 317, 112-9 (2010). 2003670820036708
659HOXA5ARP31447_P050Boucherat, O. et al. Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis. Am. J. Physiol. Lung Cell. Mol. Physiol. 304, L817-30 (2013). 2358522923585229
660HOXA7OAAB10779Epigenetic dysregulation of key developmental genes in radiation-induced rat mammary carcinomas. Int J Cancer. 143, 343-354 (2018) 2943598329435983
661HOXC6ARP38484_P050Intrinsic control of neuronal diversity and synaptic specificity in a proprioceptive circuit. Elife 2020 NULL 9 NULL 3280892432808924
662HOXC9ARP35813_T100Hur, H., Lee, J.-Y., Yun, H. J., Park, B. W. & Kim, M. H. Analysis of HOX Gene Expression Patterns in Human Breast Cancer. Mol. Biotechnol. 56, 64-71 (2014). 2382098023820980
663HOXC9ARP35813_T100Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1. Neuro-oncology. 18, 819-29 (2016). 2658293026582930
664HOXD12ARP32647_T100Illig, R., Fritsch, H. & Schwarzer, C. Spatio-temporal expression of HOX genes in human hindgut development. Dev. Dyn. 242, 53-66 (2013). 2307399423073994
665HPRT1OAAB03804Göttle, M. et al. Loss of dopamine phenotype among midbrain neurons in Lesch-Nyhan disease. Ann. Neurol. 76, 95-107 (2014). 2489113924891139
666HPSEARP60766_P050High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature. Cardiovasc Res. 112, 656-668 (2016). 2797981127979811
667HPSEARP60766_P050The exostosin family of glycosyltransferases: mRNA expression profiles and heparan sulphate structure in human breast carcinoma cell lines. Biosci Rep. 38, (2018). 3005443030054430
668HRH1OAEB00846Localization of histamine (H1, H2, H3 and H4) receptors in mouse inner ear. Acta Otolaryngol. 136, 537-44 (2016). 2685412726854127
669HRPOAIA00498Bioaffinity-based surface immobilization of antibodies to capture endothelial colony-forming cells. PLoS One e0269316 17 8 August 202236040884
670HSD11B1ARP45714_P050Lei, K. et al. Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1beta-induced COX-2 expression in human term myometrial cells. PLoS One 7, e50167 (2012). 2320966423209664
671HSD11B1ARP45714_P050Kuroda, K. et al. Induction of 11beta-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Mol. Endocrinol. 27, 192-202 (2013). 2327545523275455
672HSD17B13OAAN01691Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease. J Lipid Res. 60, 176-185 (2019). 3032311230323112
673HSD17B3OAAB06112Bertin, J., Dury, A. Y., Ouellet, J., Pelletier, G. & Labrie, F. Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction. J. Sex. Med. 11, 1949-61 (2014). 2491954124919541
674HSD17B6ARP41529_T100Mohler, J. L. et al. Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer. Cancer Res. 71, 1486-96 (2011). 2130397221303972
675HSD17B6ARP41529_T100Muthusamy, S. et al. Estrogen receptor beta and 17beta-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer. Proc. Natl. Acad. Sci. U. S. A. 108, 20090-4 (2011). 2211419422114194
676HSD3B2OAGA02009NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice. J Endocrinol. 236, 13-28 (2018). 2904634029046340
677HSD3B2OAGA02009Fei Wang, et al. Roles of Sialic Acid, AXL, and MER Receptor Tyrosine Kinases in Mumps Virus Infection of Mouse Sertoli and Leydig Cells. 1292 (2020). 3269507432695074
678HSP90AA1OAED00192Heat Shock Alters the Proteomic Profile of Equine Mesenchymal Stem Cells. Int J Mol Sci 2022 13 23 NULL 3580623735806237
679HSPA8ARP48445_P050Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess a-Synuclein at Synapses. Eneuro. 7, (2020). 3194165931941659
680HSPA8ARP48445_P050Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity. Front Synaptic Neurosci 2022 NULL 14 855673 3557366235573662
681HSPB1ARP30177_T100Narjoz, C. et al. Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells. Chem. Res. Toxicol. 22, 779-87 (2009). 1944553119445531
682HSPB1ARP30177_T100Heat Shock Protein 27 is down-regulated in Ballooned Hepatocytes of Patients with Nonalcoholic Steatohepatitis (NASH). Sci Rep. 6, 22528 (2016). 2693503026935030
683HSPH1ARP52217_P050Expression and function of HSP110 family in mouse testis after vasectomy. Asian J. Androl. (2016). 2695295526952955
684HTR3AAVARP13046_P050Rinaldi, A. et al. Serotonin receptor 3A expression in normal and neoplastic B cells. Pathobiology 77, 129-35 (2010). 2051672820516728
685HVCN1OAPB01154Genetic variation of staphylococcal LukAB toxin determines receptor tropism. Nat Microbiol. 6, 731-745 (2021). 3387584733875847
686IDH3AARP42237_T100Lin, C.-C. et al. Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy. Sci. Rep. 2, 785 (2012). 2313985823139858
687IDH3AARP42237_T100Alteration of isocitrate dehydrogenase following acute ischemic injury as a means to improve cellular energetic status in neuroadaptation. CNS Neurol Disord Drug Targets. 12, 849-60 (2013). 2346983923469839
688IDO2OAAB08672Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas. Neuro Oncol. 17, 1284-92 (2015). 2609277426092774
689IDO2OAAB08672Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma. Mol Imaging. 15, (2016). 2715113627151136
690IDO2OAAB08672Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors. J Neurooncol. 139, 239-249 (2018). 2966708429667084
691IER2ARP34401_P050IER2-induced senescence drives melanoma invasion through osteopontin. Oncogene. 40, 6494-6512 (2021). 3461130934611309
692IFIT3ARP46034_P050Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus. Sci Rep. 5, 15662 (2015). 2648976226489762
693IFNB1OAAB05131Sanderson, S. D. et al. Innate immune induction and influenza protection elicited by a response-selective agonist of human C5a. PLoS One 7, e40303 (2012). 2279227022792270
694IFNLR1ARP48070_P050Pseudorabies Virus Inhibits Type I and Type III Interferon-Induced Signaling via Proteasomal Degradation of Janus Kinases. J Virol 2021 20 95 e0079321 3437950534379505
695IGF1RAVARP00004_P050Kubota, T. et al. Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading. Acta Astronaut. 92, 73-78 (2013). 2397680223976802
696IGF1RAVARP00004_P050Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation. Gen Comp Endocrinol. 263, 51-61 (2018). 2964941829649418
697IGF2OAAB07463Modulation of IGF2 Expression in the Murine Thymus and Thymic Epithelial Cells Following Coxsackievirus-B4 Infection. Microorganisms. 9 (2021) 3367201033672010
698IGF2BP1ARP40658_P050Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. Mol Cell. 74, 701-712.e9 (2019). 3094826630948266
699IGFBP4ARP45685_P050Shi, Z., Chiang, C.-I., Mistretta, T.-A., Major, A. & Mori-Akiyama, Y. SOX9 directly regulates IGFBP-4 in the intestinal epithelium. Am. J. Physiol. Gastrointest. Liver Physiol. 305, G74-83 (2013). 2366050023660500
700IGGASP00001Effects of Ethanol on the Expression Level of Various BDNF mRNA Isoforms and Their Encoded Protein in the Hippocampus of Adult and Embryonic Rats. Int J Mol Sci. 16, 30422-37 (2015). 2670357826703578
701IGGASP00001Differential Effects of Resveratrol on the Expression of Brain-Derived Neurotrophic Factor Transcripts and Protein in the Hippocampus of Rat Brain. Iran J Med Sci. 42, 32-39 (2017). 2829304828293048
702IgGASP00001Divergent Hemogen genes of teleosts and mammals share conserved roles in erythropoiesis: analysis using transgenic and mutant zebrafish. Biol Open. 7, (2018). 3009752030097520
703IgGASP00001Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells. Cancer Biol Ther. 13, 908-14 (2012) 2278520622785206
704IgGOARA04973Divergent Hemogen genes of teleosts and mammals share conserved roles in erythropoiesis: analysis using transgenic and mutant zebrafish. Biol Open. 7, (2018). 3009752030097520
705IgG-HRPASP00001Chung, W.-G., Sandoval, M. A., Sloat, B. R., Lansakara-P, D. S. P. & Cui, Z. Stearoyl gemcitabine nanoparticles overcome resistance related to the over-expression of ribonucleotide reductase subunit M1. J. Control. Release 157, 132-40 (2012). 2185184321851843
706IGHG2COASB01582Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells. Nat Commun. 12, 3789 (2021) 3414527934145279
707IHHARP45230_T100Mirza, R. et al. 3beta-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species. J. Bone Miner. Metab. 30, 144-53 (2012). 2184551721845517
708IL1BARP54323_P050Wang, F. et al. Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-κB p65 protein. Cell. Microbiol. 15, 474-85 (2013). 2308310223083102
709IL1BARP54323_P0501a,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. J Alzheimers Dis. 34, 155-70 (2012). 2318698923186989
710IL1BARP54323_P050Circulating microparticles enhanced rat vascular wall remodeling following endothelial denudation. Am J Transl Res. 8, 4511-4522 (2016). 2790465827904658
711IL-1bOAPA00159Chronic rapamycin treatment decreases hepatic IL-6 protein, but increases autophagy markers as a protective effect against the overtraining-induced tissue damage. Clin Exp Pharmacol Physiol 893-902 49 8 August 202235637552
712IL25OAAB10988Expression of IL-25, IL-33, and Thymic Stromal Lymphopoietin in Nasal Polyp Gland Duct Epithelium in Patients With Chronic Rhinosinusitis. Am J Rhinol Allergy. 33, 378-387 (2019). 3087384630873846
713ILF2ARP35731_T100Jiang, D., Zhou, Y., Moxley, R. A. & Jarrett, H. W. Purification and identification of positive regulators binding to a novel element in the c-Jun promoter. Biochemistry 47, 9318-34 (2008). 1869071818690718
714ILF2ARP35731_T100Yamauchi, T. et al. Sepantronium bromide (YM155) induces disruption of the ILF3/p54(nrb) complex, which is required for survivin expression. Biochem. Biophys. Res. Commun. 425, 711-6 (2012). 2284245522842455
715IQCKARP53134_P050Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer's disease. Front Cell Neurosci 954071 16 NULL August 202235928571
716IRAK1OABF01186Afghanistan Particulate Matter Enhances Pro-Inflammatory Responses in IL-13-Exposed Human Airway Epithelium via TLR2 Signaling. Toxicol Sci. 166, 345-353 (2018). 3016975030169750
717IRF3OAAF00779Dong, X.-Y. et al. Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-κB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages. Virol. J. 10, 286 (2013). 2403455924034559
718IRF6ARP31995_P050Iwata, J. et al. Smad4-Irf6 genetic interaction and TGFbeta-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Development 140, 1220-30 (2013). 2340690023406900
719ISGF3GARP31200_P050Bidwell, B. N. et al. Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape. Nat. Med. 18, 1224-31 (2012). 2282064222820642
720JHDM2AARP32911_T100Zhou, X., Sun, H., Ellen, T. P., Chen, H. & Costa, M. Arsenite alters global histone H3 methylation. Carcinogenesis 29, 1831-6 (2008). 1832186918321869
721JOSD3OAAB03009Expression Atlas of the Deubiquitinating Enzymes in the Adult Mouse Retina, Their Evolutionary Diversification and Phenotypic Roles. PLoS ONE. 11, e0150364 (2016). 2693404926934049
722JUNP100911_P050Russo, R. et al. The newly characterized Pl-jun is specifically expressed in skeletogenic cells of the Paracentrotus lividus sea urchin embryo. FEBS J. 281, 3828-43 (2014). 2504050525040505
723KCNAB2ARP37678_T100Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits. J Mol Cell Cardiol. 137, 93-106 (2019). 3163938931639389
724KCNK9ARP35260_P050Epigenetic Dysregulation of KCNK9 Imprinting and Triple-Negative Breast Cancer. Cancers (Basel) 2021 23 13 NULL 3488513934885139
725KCNMA1ARP35092_P050Molecular phenotyping of the surfaceome of migratory chondroprogenitors and mesenchymal stem cells using biotinylation, glycocapture and quantitative LC-MS/MS proteomic analysis. Sci Rep. 9, 9018 (2019). 3122773931227739
726KCNN2ARP35094_T100Chakroborty, S. et al. Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer’s disease mice. J. Neurosci. 32, 8341-53 (2012). 2269991422699914
727KCNN2ARP35439_P050Chakroborty, S. et al. Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer’s disease mice. J. Neurosci. 32, 8341-53 (2012). 2269991422699914
728KCNQ1ARP34924_P050Zhou, S. et al. Antiarrhythmic effects of beta3-adrenergic receptor stimulation in a canine model of ventricular tachycardia. Heart Rhythm 5, 289-97 (2008). 1824255618242556
729KCNQ2ARP35459_T100Zhang, H. et al. Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents. Neuroscience 254, 70-9 (2013). 2403637524036375
730KCNQ2ARP35459_T100Functional responses of the hippocampus to hyperexcitability depend on directed, neuron-specific KCNQ2 K+ channel plasticity. Hippocampus. 30, 435-455 (2020) 3162198931621989
731KCNQ3OAAF00246Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflugers Arch. 470, 1359-1376 (2018). 2979706729797067
732KCTD10OAAB09706Wang, Y. et al. KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation. J. Cell. Biochem. 106, 409-13 (2009). 1912541919125419
733KDM6BARP40102_T100Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev 2009 10 23 1177-82 1945121819451218
734KDROAEC00429Silence of lncRNA UCA1 Represses the Growth and Tube Formation of Human Microvascular Endothelial Cells Through miR-195. Cell Physiol Biochem. 49, 1499-1511 (2018). 3020537730205377
735KEAP1ARP34728_T100Protein levels in Keap1-Nrf2 system in human failing heart. Int. J. Cardiol. 225, 62-64 (2016). 2771080527710805
736KEAP1OACD04962Virus Infection Induces Keap1 Binding to Cytokine Genes, Which Recruits NF-κB p50 and G9a-GLP and Represses Cytokine Transcription. J Immunol 2021 5 207 1437-1447 3440052234400522
737KHSRPARP40474_P050Ahn, Y.-H. et al. Electrophilic tuning of the chemoprotective natural product sulforaphane. Proc. Natl. Acad. Sci. U. S. A. 107, 9590-5 (2010). 2043974720439747
738KIAA0317ARP44874_P050Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4. J Exp Med. 2016 May 30; 213(6): 1029-1046. 2716213927162139
739KIF5BARP33903_P050Turner, L. S. et al. Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide. Prostate Cancer Prostatic Dis. 14, 30-7 (2011). 2111628621116286
740KIM1OABB00585Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation. J. Urol. 194, 1806-15 (2015). 2623933626239336
741KITOAEE00056Expression of Luminal Progenitor Marker CD117 in the Human Breast Gland. J Histochem Cytochem. 66, 879-888 (2018). 3000428830004288
742KLBARP53325_P050Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury. EBioMedicine 104181 82 NULL August 202235908416
743KLF2ARP32760_P050Yamada, T., Park, C. S., Mamonkin, M. & Lacorazza, H. D. Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2. Nat. Immunol. 10, 618-26 (2009). 1941218219412182
744KLF4ARP38430_P050BMP- and TGFβ-signaling regulate the formation of Müller glia-derived progenitor cells in the avian retina. Glia. 65, 1640-1655 (2017). 2870329328703293
745Klf4OAAD00376Luz-Madrigal, A. et al. Reprogramming of the chick retinal pigmented epithelium after retinal injury. BMC Biol. 12, 28 (2014). 2474227924742279
746KLF4ARP38430_P050Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of Müller Glia-Derived Progenitor Cells in the Avian Retina. Stem Cells 2018 3 36 392-405 2919345129193451
747KLF8ARP31533_P050Fu, W.-J. et al. Small interference RNA targeting Krüppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo. J. Cancer Res. Clin. Oncol. 136, 1255-65 (2010). 2018288920182889
748KLF8ARP31533_P050Li, J.-C. et al. Up-regulation of Krüppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma. Gastroenterology 139, 2146-2157.e12 (2010). 2072844920728449
749KLF8ARP31533_P050Han, S. et al. Krüppel‑like factor expression and correlation with FAK, MMP‑9 and E‑cadherin expression in hepatocellular carcinoma. Mol. Med. Rep. 8, 81-8 (2013). 2367071723670717
750KLF8ARP31533_P050KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2. Oncotarget. 6, 25402-17 (2015). 2632017226320172
751KMOOAAB05255Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas. Cells. 10, NULL (2021) 3444079834440798
752L1CAMOAAB11621Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus. Proc Natl Acad Sci U S A 2021 33 118 NULL 3438073334380733
753LAMP1OAAB13754Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling. Autophagy. 13, 1855-1869 (2017). 2882585128825851
754LAMP2OAAB06711Lysosomes, autophagosomes and Alzheimer pathology in dementia with Lewy body disease. Neuropathology NULL NULL NULL May 201829748975
755LBPARP41546_P050Seasonal heat load is more potent than the degree of body weight loss in dysregulating immune function by reducing white blood cell populations and increasing inflammation in Holstein dairy cows. J Dairy Sci. 103, 10809-10822 (2020). 3289640132896401
756LC3-IIOAAB13483NKCT1 (purified Naja kaouthia protein toxin) conjugated gold nanoparticles induced Akt/mTOR inactivation mediated autophagic and caspase 3 activated apoptotic cell death in leukemic cell. Toxicon. 121, 86-97 (2016). 2752727027527270
757LEPARP41697_P050Leptin in the canine uterus and placenta: possible implications in pregnancy. Reprod Biol Endocrinol. 13, 13 (2015). 2587142225871422
758LEPARP41698_P050Proteomic Analysis of Plasma Reveals Fat Mass Influences Cancer-Related Pathways in Healthy Humans Fed Controlled Diets Differing in Glycemic Load. Cancer Prev Res (Phila). 12, 567-578 (2019). 3126682631266826
759LEPTINARP41697_P050Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs. Reprod. Domest. Anim. 52 Suppl 2, 187-192 (2017). 2810189128101891
760LGALS3ARP54688_P050Guha, P. et al. Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, a9 nicotinic acetylcholine receptor and STAT3. Breast Cancer Res. Treat. 145, 5-22 (2014). 2466850024668500
761LHX6ARP32553_T100Genome-wide screening for deubiquitinase subfamily identifies ubiquitin-specific protease 49 as a novel regulator of odontogenesis. Cell Death Differ 2022 NULL NULL NULL 3527336235273362
762LIPEOAAF00742Shao-Wei Lu, et al. IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. 4611 (2020). 3292907232929072
763LMNB2ARP46356_P050The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes Dev. 29, 1224-38 (2015). 2608081626080816
764LOC100009097OASB00822Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis. Cell Rep. 25, 57-67.e5 (2018). 3028203830282038
765LOX1OACD05298Molecular mechanism of statin-mediated LOX-1 inhibition. Cell Cycle. 14, 1583-95 (2015). 2595019225950192
766LOX15OAAB04977Starowicz, K. et al. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. PLoS One 8, e60040 (2013). 2357323023573230
767LRP1ARP58562_P050Behl, M., Zhang, Y., Monnot, A. D., Jiang, W. & Zheng, W. Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1. Toxicol. Appl. Pharmacol. 240, 245-54 (2009). 1950111219501112
768LRP1ARP58562_P050Gu, H. et al. Lead exposure increases levels of beta-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice. Neurosci. Lett. 490, 16-20 (2011). 2116791321167913
769LRP1ARP58562_P050Hentschke, M. R. et al. Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. J. Lipid Res. 54, 2658-64 (2013). 2389804923898049
770MAFAARP47760_P050Molecular and genetic regulation of pig pancreatic islet cell development. Development 2020 NULL NULL NULL 3400477334004773
771MAP1LC3AARP51335_P050Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischaemia/reperfusion injury by inhibiting glycogen synthase kinase-3β-mediated activation of autophagy. Br J Pharmacol. 177, 1434-1452 (2020). 3165836431658364
772MAP2KARP42065_P050Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model. Endocrinology 2017 3 158 560-577 2835908928359089
773MAP2K7OAAF05547Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 7, 10592 (2016). 2688298926882989
774MAP2K7OAAF05547Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates. Nat. Med. 23, 439-449 (2017). 2821891928218919
775MAP2K7OAAF05547Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis. Nat Commun 2022 1 13 669 3511555635115556
776MAP3K7IP2ARP32402_P050Thienpont, B. et al. Haploinsufficiency of TAB2 causes congenital heart defects in humans. Am. J. Hum. Genet. 86, 839-49 (2010). 2049345920493459
777MARVELD3ARP44715_P050α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function. Exp Neurol. 285, 72-81 (2016) 2763290027632900
778MATR3ARP40922_T100Valencia, C. A., Ju, W. & Liu, R. Matrin 3 is a Ca2+/calmodulin-binding protein cleaved by caspases. Biochem. Biophys. Res. Commun. 361, 281-6 (2007). 1765846017658460
779MATR3ARP40922_T100Kula, A. et al. Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function. Retrovirology 8, 60 (2011). 2177134621771346
780MATR3ARP40922_T100Kula, A., Gharu, L. & Marcello, A. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3. Virology 435, 329-40 (2013). 2315810223158102
781MAZARP38146_P050Smits, M. et al. Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma. FASEB J. 26, 2639-47 (2012). 2241530122415301
782MBD2ARP32485_P050Jungwirth, M., Dear, M. L., Brown, P., Holbrook, K. & Goodchild, R. Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA. Hum. Mol. Genet. 19, 888-900 (2010). 2003402520034025
783MBNL1ARP41227_P050Muscleblind-like 1 is required for normal heart valve development in vivo. BMC Dev. Biol. 15, 36 (2015). 2647224226472242
784MBPOABB00147Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. PLoS ONE. 11, e0148238 (2016). 2682932526829325
785mCherry-TagOAAF04756Monocarboxylate Transporter 4 in Cancer-Associated Fibroblasts Is a Driver of Aggressiveness in Aerodigestive Tract Cancers. Front Oncol 2022 NULL 12 906494 3581436435814364
786MCM8ARP36668_P050Ono, A. et al. Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues. Hum. Pathol. 40, 41-9 (2009). 1875549918755499
787MDH2ARP48286_T1002-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training. Proteomics 2011 8 11 1413-28 2136067021360670
788MED17ARP34192_P050DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes. Nat Commun. 5, 4263 (2014). 2496887424968874
789MED17ARP34192_P050Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor. J Clin Invest. 125, 183-93 (2015). 2543787525437875
790MED25OAAB00209Synergistic activation of Arg1 gene by retinoic acid and IL-4 involves chromatin remodeling for transcription initiation and elongation coupling. Nucleic Acids Res. 44, 7568-79 (2016). 2716637427166374
791MEF2COAGA02537MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS. Bone Res. 9, 4 (2021). 3342402233424022
792MEIS2ARP34684_T100Jackson, B. et al. TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier. J. Cell Sci. 124, 1681-90 (2011). 2151173221511732
793MEROAAF00456Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase. Cell Commun. Signal. 14, 19 (2016). 2759598127595981
794METTL3ARP39390_T100N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation. Dev Cell. 55, 737-753.e7 (2020). 3322017433220174
795MFN2ARP42420_P050Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIa to induce mitochondrial fragmentation. Sci Rep. 6, 23464 (2016). 2701010027010100
796Mif4GDARP40950_T100Okada, K. et al. Expression analysis of MIF4GD in the rat testis. J. Reprod. Dev. 57, 256-61 (2011). 2115712221157122
797MINOS1ARP44801_P050QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease. Elife 2016 NULL 5 NULL 2762314727623147
798MIWIARP41339_P050Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression. J. Cell. Sci. 130, 1463-1474 (2017). 2825488628254886
799MKI67OAAF01852Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure. Stem Cell Res Ther. 8, 70 (2017). 2832048528320485
800MMP10OAAF01865Inside the Thrombus: Association of Hemostatic Parameters With Outcomes in Large Vessel Stroke Patients. Front Neurol. 12, 599498 (2021) 3369273733692737
801MMP10OAAI00209Matrix Metalloproteinase 10 Contributes to Choroidal Neovascularisation. Biomedicines NULL 10 7 June 202235884862
802MMP13ARP56350_P050Alleviation of Murine Osteoarthritis by Cartilage-Specific Deletion of IκBζ. Arthritis Rheumatol 1440-1449 70 9 September 201829604191
803MMP2AVARP20016_T100TNF-a promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts. Cell Oncol (Dordr). 39, 353-63 (2016). 2704282727042827
804MMP2AVARP20016_T100Developmental Programming: Gestational Exposure to Excess Testosterone Alters Expression of Ovarian Matrix Metalloproteases and Their Target Proteins. Reprod Sci. 1933719117697127 (2017). 2829999228299992
805MMP3ARP42042_P050Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation. J Orthop Res. (2020) 3272590432725904
806MMP3OAAF01874Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis. J Pain Res. 10, 1973-1989 (2017). 2886085228860852
807MMP9ARP33090_T100Gotschy, A. et al. Local arterial stiffening assessed by MRI precedes atherosclerotic plaque formation. Circ. Cardiovasc. Imaging 6, 916-23 (2013). 2410004424100044
808MMP9ARP33090_T100Li, L. et al. DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression depending on Notch signaling. PLoS One 9, e91509 (2014). 2462161224621612
809MMP9ARP33090_T100Developmental Programming: Gestational Exposure to Excess Testosterone Alters Expression of Ovarian Matrix Metalloproteases and Their Target Proteins. Reprod Sci. 1933719117697127 (2017). 2829999228299992
810MMP-9ARP33090_T100Zhang, J., Jiang, W. & Zuo, Z. Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor κB. Neuroscience 261, 1-10 (2014). 2436546224365462
811MMP-9ARP33090_T100Deng, J., Zhang, J., Feng, C., Xiong, L. & Zuo, Z. Critical role of matrix metalloprotease-9 in chronic high fat diet-induced cerebral vascular remodelling and increase of ischaemic brain injury in mice. Cardiovasc. Res. 103, 473-84 (2014). 2493542724935427
812MMP-9ARP33090_T100Immunohistochemical determination of the extracellular matrix modulation in a rat model of choline-deprived myocardium: the effects of carnitine. Fundam Clin Pharmacol. 30, 47-57 (2016). 2650149326501493
813MOGOAPA00088Oral Tolerance Induction in Experimental Autoimmune Encephalomyelitis with Candida utilis Expressing the Immunogenic MOG35-55 Peptide. PLoS ONE. 11, e0155082 (2016). 2715944627159446
814MRAPOAAB06581Exome-based investigation of the genetic basis of human pigmentary glaucoma. BMC Genomics. 22, 477 (2021) 3417483234174832
815MRC1OASA05048Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice. Gastroenterology. 154, 704-718.e10 (2018). 2907951729079517
816MRC1OASA05048NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis. Gastroenterology. 158, 253-269.e14 (2020). 3159370031593700
817MRG15ARP32832_T100Xie, L. et al. KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription. EMBO J. 30, 1473-84 (2011). 2144813421448134
818MRPS15ARP33299_P050Davies, S. M. K. et al. Pentatricopeptide repeat domain protein 3 associates with the mitochondrial small ribosomal subunit and regulates translation. FEBS Lett. 583, 1853-8 (2009). 1942785919427859
819MSH2OAAF03051A rapidly growing human papillomavirus-positive oral tongue squamous cell carcinoma in a 21-year old female: A case report. Oncol Lett. 15, 7702-7706 (2018). 2984979929849799
820MSNARP63015_P050Li, J. et al. A strategy to rapidly identify the functional targets of microRNAs by combining bioinformatics and mRNA cytoplasmic/nucleic ratios in culture cells. FEBS Lett. 584, 3198-202 (2010). 2054715820547158
821MSX1ARP31396_T100Mizokami, Y. et al. Expression of MSX1 in human normal pituitaries and pituitary adenomas. Endocr. Pathol. 19, 54-61 (2008). 1837990018379900
822MTf2ARP34292_P050Loss of PRC2 subunits primes lineage choice during exit of pluripotency. Nat Commun 2021 1 12 6985 3484873334848733
823Mthfd1OAAB01489Thangavel, M. et al. Proteomic analysis of rat prefrontal cortex after chronic valproate treatment. J. Neurosci. Res. 92, 927-36 (2014). 2469202224692022
824MTNR1BOABF00337Melatonin Type 2 Receptor Activation Regulates Blue Light Exposure-Induced Mouse Corneal Epithelial Damage by Modulating Impaired Autophagy and Apoptosis. Int J Mol Sci NULL 23 19 September 202236232639
825MTRRARP57657_P050Richard, E., Desviat, L. R., Ugarte, M. & Pérez, B. Oxidative stress and apoptosis in homocystinuria patients with genetic remethylation defects. J. Cell. Biochem. 114, 183-91 (2013). 2288747722887477
826MTUS1ARP44419_P050Negative regulation of EB1 turnover at microtubule plus ends by interaction with microtubule-associated protein ATIP3. Oncotarget. 6, 43557-70 (2015). 2649835826498358
827MTUS1ARP44419_P050Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length. Cell Mol Life Sci 2021 4 78 1765-1779 3278968932789689
828MUC1ARP41446_T100Autophagy is decreased in triple-negative breast carcinoma involving likely the MUC1-EGFR-NEU1 signalling pathway. Int J Clin Exp Pathol. 8, 4344-55 (2015). 2619112626191126
829MUC1ARP41446_T100GABA selectively increases mucin-1 expression in isolated pig jejunum. Genes Nutr. 10, 47 (2015). 2647179226471792
830Muc19OAEB02736Salivary gland organoid culture maintains distinct glandular properties of murine and human major salivary glands. Nat Commun 2022 1 13 3291 3567241235672412
831MVPOAGA01032Major Vault Protein, a Candidate Gene in 16p11.2 Microdeletion Syndrome, Is Required for the Homeostatic Regulation of Visual Cortical Plasticity. J Neurosci. 38, 3890-3900 (2018). 2954055429540554
832MX1ARP46077_P050Spellman, C., Ahmed, M. M., Dubach, D. & Gardiner, K. J. Expression of trisomic proteins in Down syndrome model systems. Gene 512, 219-225 (2013). 2310382823103828
833MYBBP1AARP37224_T100Zheng, B. et al. Establishment of a proteomic profile associated with gonocyte and spermatogonial stem cell maturation and differentiation in neonatal mice. Proteomics 14, 274-85 (2014). 2433925624339256
834MYCBPARP31860_P050Cowell, J. K. & Hawthorn, L. The application of microarray technology to the analysis of the cancer genome. Curr. Mol. Med. 7, 103-20 (2007). 1731153617311536
835MYCBPARP31860_P050Ramírez-Valle, F., Braunstein, S., Zavadil, J., Formenti, S. C. & Schneider, R. J. eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. J. Cell Biol. 181, 293-307 (2008). 1842697718426977
836MYF5OALA07435Deficient muscle regeneration potential in sarcopenic COPD patients: Role of satellite cells. J Cell Physiol 2021 4 236 3083-3098 3298980532989805
837MYH7ARP41380_P050Tijore, A. et al. Investigating the Spatial Distribution of Integrin beta1 in Patterned Human Mesenchymal Stem Cells Using Super-Resolution Imaging. ACS Appl. Mater. Interfaces 6, 15686-96 (2014). 2515369425153694
838MYH7ARP41380_P050Role of Cytoskeletal Tension in the Induction of Cardiomyogenic Differentiation in Micropatterned Human Mesenchymal Stem Cell. Adv Healthc Mater. 4, 1399-407 (2015). 2594661525946615
839Myh7ARP41380_P050High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy. Cell Death Dis 2021 2 12 216 3363771533637715
840N/AOAEA00010Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA. Nat Commun 2022 1 13 1072 3522852635228526
841N/AOAMA00794Comparison of methods for quantitative biomolecular interaction analysis. Anal Bioanal Chem 2022 1 414 661-673 3450516434505164
842N/AAMM99021Epigenomic features of DNA G-quadruplexes and their roles in regulating rice gene transcription. Plant Physiol 2022 3 188 1632-1648 3489390634893906
843NAB1ARP32032_P050Shimoyamada, H. et al. Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells. Am. J. Pathol. 177, 70-83 (2010). 2048915620489156
844NAMPTARP42255_T100Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight. Br. J. Pharmacol. (2017). 2805510528055105
845NANOGOAAB11202Identification and characterisation of NANOG+/ OCT-4high/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines. Oncotarget. 9, 7054-7065 (2018). 2946794929467949
846NANOGOAAB11202Doxorubicin resistant choriocarcinoma cell line derived spheroidal cells exhibit stem cell markers but reduced invasion. 3 Biotech 184 12 9 September 202235875180
847NARSOAAB07325Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics. Nat Cell Biol 307-315 24 3 March 202235288656
848NEU1ARP44286_T100Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll-like Receptor 4. J Neurochem. 155, 403-416 (2020) 3227931532279315
849NEU1ARP44286_T100Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5. Glycobiology. 28, 306-317 (2018) 2989758329897583
850NFIAARP32714_P050DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. Elife 2021 NULL 10 NULL 3387135633871356
851NFKB1OAAI00072Crucial role of OX40/OX40L signaling in a murine model of asthma. Mol Med Rep. 17, 4213-4220 (2018). 2934466429344664
852NFKB2ARP32718_P050Tissue-specific transcription profile of cytokine and chemokine genes associated with flavivirus control and non-lethal neuropathogenesis in rabbits. Virology. 494, 1-14 (2016). 2706105227061052
853NF-κB2ARP32043_P050Volger, O. L. et al. Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis. Am. J. Pathol. 171, 326-37 (2007). 1759197717591977
854NF-κB2ARP32043_P050Wang, C.-Y., Yang, P., Li, M. & Gong, F. Characterization of a negative feedback network between SUMO4 expression and NFkappaB transcriptional activity. Biochem. Biophys. Res. Commun. 381, 477-81 (2009). 1922299019222990
855NIP7ARP40833_T100Zinzalla, V., Stracka, D., Oppliger, W. & Hall, M. N. Activation of mTORC2 by association with the ribosome. Cell 144, 757-68 (2011). 2137623621376236
856NKCC2ARP41388_P050Kelsen, S. et al. Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells. Am. J. Physiol. Renal Physiol. 295, F1158-65 (2008). 1870163418701634
857NKCC2ARP41388_P050Stec, D. E. et al. Expression of heme oxygenase-1 in thick ascending loop of henle attenuates angiotensin II-dependent hypertension. J. Am. Soc. Nephrol. 23, 834-41 (2012). 2232364422323644
858NKCC2ARP41388_P050Polyuria-associated hydronephrosis induced by xenobiotic chemical exposure in mice. Am. J. Physiol. Renal Physiol. 311, F752-F762 (2016). 2744077527440775
859NLRC4AVARP00019_P050Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation. Am J Physiol Renal Physiol. 306, F299-308 (2014). 2428549924285499
860NLRC4AVARP00019_P050The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells). Int Urol Nephrol. 47, 1953-64 (2015). 2649055626490556
861NLRC4AVARP00019_P050Immunohistochemical Study of ASC Expression and Distribution in the Hippocampus of an Aged Murine Model of Alzheimer's Disease. Int J Mol Sci 2021 16 22 NULL 3444540234445402
862NLRP3ARP63297_P050Tongxinluo May Alleviate Inflammation and Improve the Stability of Atherosclerotic Plaques by Changing the Intestinal Flora. Front Pharmacol 2022 NULL 13 805266 3543193935431939
863NOTCH4ARP32726_P050Sun, Y. et al. Trp53 regulates Notch 4 signaling through Mdm2. J. Cell Sci. 124, 1067-76 (2011). 2140287621402876
864NOTCH4ARP32726_P050Notch-Induced Expression of FZD7 Requires Noncanonical NOTCH3 Signaling in Human Breast Epithelial Cells. Stem Cells Dev. 25, 522-9 (2016). 2684750326847503
865NPM1ARP34094_T100Komorek, J. et al. Adenovirus type 5 E1A and E6 proteins of low-risk cutaneous beta-human papillomaviruses suppress cell transformation through interaction with FOXK1/K2 transcription factors. J. Virol. 84, 2719-31 (2010). 2005374620053746
866NR1I2ARP36016_P050Sivertsson, L., Edebert, I., Palmertz, M. P., Ingelman-Sundberg, M. & Neve, E. P. A. Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation. Mol. Pharmacol. 83, 659-70 (2013). 2326449623264496
867NR1I2ARP36016_P050Dou, W. et al. Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway. J. Pharmacol. Exp. Ther. 345, 473-82 (2013). 2353631623536316
868NR2F2P100816_P050Déjardin, J. & Kingston, R. E. Purification of proteins associated with specific genomic Loci. Cell 136, 175-86 (2009). 1913589819135898
869NR4A1ARP31941_T100Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation. Mol Cell. 69, 480-492.e7 (2018). 2939506529395065
870NR4A1ARP45604_P050Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development. Neuron. 91, 1219-27 (2016). 2765744927657449
871NR4A2ARP38753_P050Epigenetic Reprogramming of Cortical Neurons through Alteration of Dopaminergic Circuits. Mol Psychiatry. 19, 1193-1200 (2014). 2502314425023144
872NRF1ARP34523_P050Teodoro, J. S. et al. Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation. Mitochondrion 13, 637-46 (2013). 2404146124041461
873NT5C3ARP32185_P050Preanalytical Stability of Gemcitabine and its Metabolite 2', 2'-Difluoro-2'-Deoxyuridine in Whole Blood-Assessed by Liquid Chromatography Tandem Mass Spectrometry. J Pharm Sci 2015 12 104 4427-4432 2637290226372902
874NUCB1P101699_T100Lin, P. et al. Calnuc binds to Alzheimer’s beta-amyloid precursor protein and affects its biogenesis. J. Neurochem. 100, 1505-14 (2007). 1734886217348862
875NUCB2ARP36567_T100Suzuki, S. et al. Nucleobindin 2 in human breast carcinoma as a potent prognostic factor. Cancer Sci. 103, 136-43 (2012). 2198859421988594
876NUCB2ARP36567_T100Nucleobindin 2 (NUCB2) in human endometrial carcinoma: a potent prognostic factor associated with cell proliferation and migration. Endocr. J. 63, 287-99 (2016). 2684271226842712
877NucleophosminARP34094_T100Lin, S., Coutinho-Mansfield, G., Wang, D., Pandit, S. & Fu, X.-D. The splicing factor SC35 has an active role in transcriptional elongation. Nat. Struct. Mol. Biol. 15, 819-26 (2008). 1864166418641664
878NUR77ARP31941_T100Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nat Commun. 8, 14420 (2017). 2824026128240261
879OAS1ARP30587_P050Li, Q. & Tainsky, M. A. Higher miRNA tolerance in immortal Li-Fraumeni fibroblasts with abrogated interferon signaling pathway. Cancer Res. 71, 255-65 (2011). 2119980621199806
880OAS1ARP51359_P050Zhu, W. et al. RIG-I-like receptors mediate innate antiviral response in mouse testis. Mol. Endocrinol. 27, 1455-67 (2013). 2382090123820901
881OAS1ARP51359_P050Yu, L. et al. Pattern recognition receptor-initiated innate antiviral response in mouse adipose cells. Immunol. Cell Biol. 92, 105-15 (2014). 2416597824165978
882OGTARP49154_P050-FITCRobust effect of metabolic syndrome on major metabolic pathways in the myocardium. PLoS One. 14, e0225857 (2019). 3179048831790488
883ONECUT1ARP38481_P050Yuan, X.-W. et al. Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition. J. Biol. Chem. 288, 31206-16 (2013). 2402248124022481
884OPN1SWARP59911_P050In vivo analysis of onset and progression of retinal degeneration in the Nr2e3rd7/rd7 mouse model of enhanced S-cone sensitivity syndrome. Sci Rep 2021 1 11 19032 3456148734561487
885OTCARP41766_T100Yu, W. et al. Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. J. Biol. Chem. 284, 13669-75 (2009). 1931835219318352
886OTCARP41766_T100Walters, M. W. & Wallace, K. B. Urea cycle gene expression is suppressed by PFOA treatment in rats. Toxicol. Lett. 197, 46-50 (2010). 2045240920452409
887OTCARP41766_T100Hallows, W. C. et al. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol. Cell 41, 139-49 (2011). 2125572521255725
888OTX2ARP32439_P050Aluigi, M. G., Angelini, C., Corte, G. & Falugi, C. The sea urchin, Paracentrotus lividus, embryo as a “bioethical” model for neurodevelopmental toxicity testing: effects of diazinon on the intracellular distribution of OTX2-like proteins. Cell Biol. Toxicol. 24, 587-601 (2008). 1822445018224450
889OTX2ARP32439_P050Machalińska, A. et al. Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: an insight into the role of glial cells in retinal repair. Exp. Eye Res. 112, 68-78 (2013). 2362399723623997
890OVOL1ARP38500_T100OVO-like 1 regulates progenitor cell fate in human trophoblast development. Proc. Natl. Acad. Sci. U.S.A. 112, E6175-84 (2015). 2650423126504231
891P2X7ARP35518_T100Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Mol. Cancer. 14, 201 (2015). 2659772326597723
892P53OAAI00285Effect of dapagliflozin and/or L-arginine on solid tumor model in mice: The interaction between nitric oxide, transforming growth factor-beta 1, autophagy, and apoptosis. Fundam Clin Pharmacol 968-978 35 6 December 202133609317
893PAOAAF04963Proteomics analysis of altered proteins in kidney of mice with aristolochic acid nephropathy using the fluorogenic derivatization-liquid chromatography-tandem mass spectrometry method. Biomed Chromatogr NULL 32 3 March 201829088495
894PABPC1OAAB01699Rbm46 regulates mouse embryonic stem cell differentiation by targeting β-Catenin mRNA for degradation. PLoS One. 12, e0172420 (2017). 2821242728212427
895PALMARP56270_P050Konzer, A. et al. Stable isotope labeling in zebrafish allows in vivo monitoring of cardiac morphogenesis. Mol. Cell. Proteomics 12, 1502-12 (2013). 2341257123412571
896PANX1ARP42783_P050Dietary Fatty Acids Affect Red Blood Cell Membrane Composition and Red Blood Cell ATP Release in Dairy Cows. Int J Mol Sci. 20, (2019). 3119570831195708
897Panx2ARP42778_T100Wang, X.-H., Streeter, M., Liu, Y.-P. & Zhao, H.-B. Identification and characterization of pannexin expression in the mammalian cochlea. J. Comp. Neurol. 512, 336-46 (2009). 1900962419009624
898Panx2ARP42778_T100Lai, C. P. K., Bechberger, J. F. & Naus, C. C. Pannexin2 as a novel growth regulator in C6 glioma cells. Oncogene 28, 4402-8 (2009). 1974978919749789
899Panx2ARP42778_T100Mylvaganam, S. et al. Hippocampal seizures alter the expression of the pannexin and connexin transcriptome. J. Neurochem. 112, 92-102 (2010). 1984021619840216
900Panx2ARP42778_T100Swayne, L. A., Sorbara, C. D. & Bennett, S. A. L. Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment. J. Biol. Chem. 285, 24977-86 (2010). 2052986220529862
901Panx2ARP42778_T100Wicki-Stordeur, L. E., Boyce, A. K. J. & Swayne, L. A. Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization. Cell Commun. Adhes. 20, 73-9 (2013). 2365928923659289
902PANX2ARP42778_T100Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells. Invest Ophthalmol Vis Sci. 58, 5654-5665 (2017). 2909829629098296
903PANX2ARP42778_T100Human stem cells express pannexins. BMC Res Notes. 11, 54 (2018). 2935794529357945
904PANX2ARP42778_T100Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes. Mol Biol Cell. mbcE21080387 (2022). 3498591334985913
905PARLARP44851_P050Yoshioka, H. et al. The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia. J. Cereb. Blood Flow Metab. 33, 1658-65 (2013). 2392189423921894
906PARLARP44851_P050Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease. Mol Neurodegener. 16, 15 (2021) 3368548333685483
907PARP12OAAB03451DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. Mol Cancer. 13, 125 (2014). 2488608924886089
908PARP16ARP33752_P050Di Paola, S., Micaroni, M., Di Tullio, G., Buccione, R. & Di Girolamo, M. PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-s1. PLoS One 7, e37352 (2012). 2270156522701565
909PARP16ARP33751_P050SMYD3-PARP16 axis accelerates unfolded protein response and mediates neointima formation. Acta Pharm Sin B 2021 5 11 1261-1273 3409483234094832
910PAX7AAP32742Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy. Hum. Mol. Genet. 25, 2465-2482 (2016). 2715419927154199
911PAX7ARP32742_P050Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration. Development. 138, 3647-56 (2011). 2182809321828093
912PAX7ARP32742_P050Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells. Development. 139, 4536-48 (2012). 2313639423136394
913PAX7ARP32742_P050Embryonic founders of adult muscle stem cells are primed by the determination gene Mrf4. Dev Biol. 381, 241-55 (2013). 2362397723623977
914Pax7ARP32742_P050McDonald, A. A., Kunz, M. D. & McLoon, L. K. Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice. PLoS One 9, e86424 (2014). 2446608524466085
915PAX7ARP32742_P050First Neuromuscular Contact Correlates with Onset of Primary Myogenesis in Rat and Mouse Limb Muscles. PLoS One. 10, e0133811 (2015). 2620775426207754
916PAX7ARP32742_P050CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury. Nat Commun. 6, 7792 (2015). 2624274626242746
917PAX7ARP32742_P050Early myogenic responses to acute exercise before and after resistance training in young men. Physiol Rep. 3, (2015). 2635923926359239
918PAX7ARP32742_P050Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis. Neuromuscul. Disord. 25, 873-87 (2015). 2642909826429098
919PAX7ARP32742_P050Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy. Hum. Mol. Genet. 25, 2465-2482 (2016). 2715419927154199
920PAX7ARP32742_P050Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7. Cell Cycle. 15, 2931-2942 (2016). 2761093327610933
921PAX7ARP32742_P050Laminin differentially regulates the stemness of type I and type II pericytes. Stem Cell Res Ther. 8, 28 (2017). 2817386128173861
922PAX7ARP32742_P050A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. J Biol Chem. 293, 13509-13523 (2018). 2999159229991592
923PAX7ARP32742_P050The transcription factor Lef1 switches partners from β-catenin to Smad3 during muscle stem cell quiescence. Sci Signal. 11, NULL (2018). 3004212930042129
924PAX7ARP32742_P050The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38a MAP kinase and redox regulation of muscle regeneration. Elife. 7, (2018). 3010637330106373
925PAX7ARP32742_P050PAX3 Confers Functional Heterogeneity in Skeletal Muscle Stem Cell Responses to Environmental Stress. Cell Stem Cell. 24, 958-973.e9 (2019). 3100662231006622
926PAX7ARP32742_P050The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts. BMC Mol Cell Biol. 21, 25 (2020). 3229324932293249
927PCBP2ARP40568_T100Han, W. et al. RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3. J. Clin. Invest. 123, 2103-18 (2013). 2358547923585479
928PCBP2ARP40568_T100Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion. Oncotarget. 7, 19483-98 (2016). 2676121226761212
929PCNAAVARP03018_T100Liu, Z. et al. Human umbilical cord mesenchymal stromal cells rescue mice from acetaminophen-induced acute liver failure. Cytotherapy 16, 1207-19 (2014). 2510865025108650
930PDE4DOAGA00330Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation. Elife. 5, (2016). 2738327027383270
931PDE5AARP63250_P050A phosphodiesterase type-5 inhibitor, sildenafil, induces sperm capacitation and penetration into porcine oocytes in a chemically defined medium. Theriogenology. 85, 428-33 (2016). 2644323426443234
932PDHA1ARP48137_T100The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development. FEBS Lett 2016 14 590 2076-85 2726493527264935
933PENKOAEB00439Stress-Related Neuronal Clusters in Sublenticular Extended Amygdala of Basal Forebrain Show Individual Differences of Positions. Front Neural Circuits. 14, 29 (2020). 3254737232547372
934PERIOSTINOAPC00052Increased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition. Front Physiol. 8, 56 (2017). 2822873128228731
935PEX3ARP46090_T100Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome. J. Biol. Chem. 291, 24231-24246 (2016). 2767953027679530
936Pfkfb2ARP56677_P050Lipid Emulsion Containing High Amounts of n3 Fatty Acids (Omegaven) as Opposed to n6 Fatty Acids (Intralipid) Preserves Insulin Signaling and Glucose Uptake in Perfused Rat Hearts. Anesth Analg 2020 1 130 37-48 3127459931274599
937PFKFB3OABF01219Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells. Am. J. Physiol., Cell Physiol. 312, C56-C70 (2017). 2785643027856430
938PHACTR1ARP55397_P050Allain, B. et al. Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells. Cell. Signal. 24, 214-23 (2012). 2193975521939755
939PHD1ARP31419_P050Tennant, D. A. & Gottlieb, E. HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression. J. Mol. Med. (Berl). 88, 839-49 (2010). 2038368920383689
940PHLDA2ARP58237_P050Dai, H. et al. TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. Carcinogenesis 33, 30-40 (2012). 2202190922021909
941Pitx2ARP35634_T100Hatou, S. et al. Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/beta-catenin signaling. Stem Cells Dev. 22, 828-39 (2013). 2297434722974347
942PKLROAGA00912AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. Blood. 130, 1347-1356 (2017). 2876088828760888
943PLCB2OAAB05844TAS2R16 Activation Suppresses LPS-Induced Cytokine Expression in Human Gingival Fibroblasts. Front Immunol. 12, 726546 (2022). 3497583434975834
944PMELARP46802_T100Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis. Genes (Basel). 11, NULL (2020). 3266878632668786
945PMS2OAAF04086A rapidly growing human papillomavirus-positive oral tongue squamous cell carcinoma in a 21-year old female: A case report. Oncol Lett. 15, 7702-7706 (2018). 2984979929849799
946PMSGOPPA01037A simple and economic protocol for efficient in vitro fertilization using cryopreserved mouse sperm. PLoS One 2021 10 16 e0259202 3471016234710162
947PNLIPARP33852_T100Itoh, M. et al. Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: consideration of pancreas differentiation. Differentiation. 80, 118-22 2053840420538404
948POGZARP39173_P050The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells. Cells 2021 10 10 NULL 3468570434685704
949POU3F1ARP44073_T100Immunohistochemical expression profiles of solute carrier transporters in alpha-fetoprotein-producing gastric cancer. Histopathology. 69, 812-821 (2016). 2724547527245475
950PPAP2AARP42721_T100Evseenko, D. et al. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One 8, e63718 (2013). 2369685023696850
951PPARAARP34068_P050Gu, Q. et al. Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. Hepatology. doi:10.1002/hep.27356 (2014). 2513042725130427
952PPARDARP38765_T100Pregnancy-associated changes of peroxisome proliferator-activated receptor delta (PPARD) and cytochrome P450 family 21 subfamily A member 2 (CYP21A2) expression in the bovine corpus luteum. J Reprod Dev. 66, 205-213 (2020). 3203737532037375
953PPARDARP38765_T100Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ. Nat Commun 2022 1 13 2665 3556237635562376
954PPP2R2BOAAB05193Combined inhibition of EZH2 and histone deacetylases as a potential epigenetic therapy for non-small-cell lung cancer cells. Cancer Sci. 107, 955-62 (2016). 2711612027116120
955PRC1OAAN02101Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models. EMBO Mol Med. 13, e13144 (2021). 3366039733660397
956PRDM1P100596_P050VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection. Cancer Cell. 28, 210-24 (2015). 2621225026212250
957PRDX1ARP48454_P050Functional genomics study of acute heat stress response in the small yellow follicles of layer-type chickens. Sci Rep. 8, 1320 (2018). 2935865629358656
958PRDX1ARP48454_P050A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells. J Food Drug Anal 2021 4 29 638-652 3564913335649133
959PRKRAARP40475_P050Yoshida, K. et al. Interaction between PKR and PACT mediated by LPS-inducible NF-κB in human gingival cells. J. Cell. Biochem. 113, 165-73 (2012). 2188222521882225
960PRLOAAB01514Reichenbach, A., Steyn, F. J., Sleeman, M. W. & Andrews, Z. B. Ghrelin receptor expression and colocalization with anterior pituitary hormones using a GHSR-GFP mouse line. Endocrinology 153, 5452-66 (2012). 2296225922962259
961PRMT2ARP40196_T100Zhong, J. et al. Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer. Gene 487, 1-9 (2011). 2182004021820040
962PRMT2ARP40196_T100Zhong, J. et al. Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma. FEBS J. 279, 316-35 (2012). 2209336422093364
963PRMT2ARP40196_T100Spellman, C., Ahmed, M. M., Dubach, D. & Gardiner, K. J. Expression of trisomic proteins in Down syndrome model systems. Gene 512, 219-225 (2013). 2310382823103828
964PRMT2ARP40196_T100Burton, A. et al. Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep. 5, 687-701 (2013). 2418366824183668
965PRMT2ARP40196_T100Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl. Dev Cell. 45, 262-275.e8 (2018). 2968919929689199
966Prp19ARP43158_T100Song, G., Cui, Y., Zhong, N. & Han, J. Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium. J. Clin. Pathol. 62, 802-7 (2009). 1940351519403515
967PSATARP46303_P050Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer. Oncology. 89, 351-9 (2015). 2643950426439504
968PSAT1ARP46303_P050Yang, Y. et al. PSAT1 regulates cyclin D1 degradation and sustains proliferation of non-small cell lung cancer cells. Int. J. Cancer (2014). doi:10.1002/ijc.29150 2514286225142862
969PSEN1ARP58941_P050Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 138, 2005-19 (2015). 2598196425981964
970PSMA1ARP40417_P050Cron, K. R. et al. Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS One 8, e73710 (2013). 2404003524040035
971PSMC5ARP38192_T100Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster. Aging Cell. 11, 634-43 (2012). 2250707522507075
972PTCH1ARP44249_P050Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma. Mol. Cancer Ther. 15, 1095-105 (2016). 2683930626839306
973PTCH1ARP44249_P050Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma. BMC Genomics. 18, 708 (2017). 2888669128886691
974PTGER1OABF01677The role of prostaglandin and E series prostaglandin receptor type 4 receptors in the development of bladder overactivity in a rat model of chemically induced prostatic inflammation. BJU Int. 124, 883-891 (2019). 3116664531166645
975PthlhARP33885_T100Zhao, C.-M. et al. Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors. Regul. Pept. 192-193C, 35-44 (2014). 2516085525160855
976PTHLHARP33885_T100Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival. J Bone Miner Res. 30, 1231-44 (2015). 2552982025529820
977PTHrPARP33885_T100Müller, M., Gagiannis, S., Nawroth, P. P., Brune, M. & Schilling, T. Activation of the receptor for parathyroid hormone and parathyroid hormone related protein induces apoptosis via the extrinsic and intrinsic signaling pathway. Int. J. Mol. Med. 24, 373-80 (2009). 1963923019639230
978PTOV1ARP50614_P050Youn, H.-S., Park, U.-H., Kim, E.-J. & Um, S.-J. PTOV1 antagonizes MED25 in RAR transcriptional activation. Biochem. Biophys. Res. Commun. 404, 239-44 (2011). 2111095121110951
979RAB11AARP63742_P050Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells. EMBO Rep. 17, 1753-1765 (2016). 2786112427861124
980RAB14AVARP13107_P050Kanzaki, H. et al. Identification of direct targets for the miR-17-92 cluster by proteomic analysis. Proteomics 11, 3531-9 (2011). 2175134821751348
981RAB14AVARP13107_P050Farhoud, M. H. et al. Impaired ubiquitin-proteasome-mediated PGC-1a protein turnover and induced mitochondrial biogenesis secondary to complex-I deficiency. Proteomics 12, 1349-62 (2012). 2258918522589185
982RAB14AVARP13107_P050Rab14 regulation of claudin-2 trafficking modulates epithelial permeability and lumen morphogenesis. Mol Biol Cell. 25, 1744-54 (2014). 2469459624694596
983RAB14AVARP13107_P050Rab11-FIP1A regulates early trafficking into the recycling endosomes. Exp Cell Res. 340, 259-73 (2016). 2679095426790954
984RAB22AARP57434_P050Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells. EMBO Rep. 17, 1753-1765 (2016). 2786112427861124
985RAB31ARP61983_P050Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency. Blood Adv 2022 NULL NULL NULL 3583907535839075
986RAB5AARP56563_P050Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells. J Extracell Vesicles. 6, 1294368 (2017). 2832617128326171
987RAD23AARP42211_T100USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions. PLoS Genet. 8, e1002470 (2012). 2229160622291606
988RAPGEF3ARP52140_P050Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids. Cells NULL 11 15 July 202235892592
989RASSF7ARP34390_T100Lim, S. et al. Carbonyl reductase 1 is an essential regulator of skeletal muscle differentiation and regeneration. Int. J. Biochem. Cell Biol. 45, 1784-93 (2013). 2062963320629633
990RB1OAAB16108Mathematical modelling of breast cancer cells in response to endocrine therapy and Cdk4/6 inhibition. J R Soc Interface. 17, 20200339 (2020). 3284289032842890
991RBM28ARP40890_P050Nousbeck, J. et al. Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis. Am. J. Hum. Genet. 82, 1114-21 (2008). 1843954718439547
992RBM38ARP40862_P050Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury. Cardiovasc Res. 115, 1804-1810 (2019). 3084304830843048
993RCOR1ARP39178_T100Packer, A. N., Xing, Y., Harper, S. Q., Jones, L. & Davidson, B. L. The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington’s disease. J. Neurosci. 28, 14341-6 (2008). 1911816619118166
994RDH12ARP52972_P050In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids. Biomed Opt Express 2022 6 13 3476-3492 3578196635781966
995RDh8ARP65373_P050In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids. Biomed Opt Express 2022 6 13 3476-3492 3578196635781966
996RETREG1ARP44827_T100FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. Mol Oncol. 13, 792-810 (2019). 3055627930556279
997RHBDL2OACA03576Thrombomodulin Functional Domains Support Osteoblast Differentiation and Bone Healing in Diabetes in Mice. J Bone Miner Res 1812-1823 35 9 September 202032329910
998RHOT1ARP44817_P050Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition. J Cell Biol. 218, 1871-1890 (2019). 3106837631068376
999RHOX8ARP36806_P050Welborn, J.P. et al. Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice. Biol Reprod. 2015 Jul; 93(1): 8. 2597201625972016
1000RHOX8ARP36807_P050Welborn, J.P. et al. Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice. Biol Reprod. 2015 Jul; 93(1): 8. 2597201625972016
1001RHOX8ARP37849_P050Welborn, J.P. et al. Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice. Biol Reprod. 2015 Jul; 93(1): 8. 2597201625972016
1002RIPK3ARP31513_T100Mesenchymal Stem/Stromal Cells and their Extracellular Vesicle Progeny Decrease Injury in Poststenotic Swine Kidney Through Different Mechanisms. Stem Cells Dev. 29, 1190-1200 (2020) 3265722932657229
1003RNF8ARP40071_T100The effects of chemotherapy with bleomycin, etoposide, and cis-platinum (BEP) on rat sperm chromatin remodeling, fecundity and testicular gene expression in the progeny. Biol Reprod. 89, 85 (2013). 2398657023986570
1004ROBO2ARP45396_P050Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function. Cell Rep 2021 3 37 109828 3468634834686348
1005ROR1OABF00363Smartphone based on-chip fluorescence imaging and capillary flow velocity measurement for detecting ROR1+ cancer cells from buffy coat blood samples on dual-layer paper microfluidic chip. Biosens Bioelectron. 153, 112042 (2020) 3205666032056660
1006RPL13ARP40217_P050Hartl, T. A. et al. Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila. Genetics 194, 101-15 (2013). 2343618023436180
1007RPL8ARP40215_T100Wong, C. C., Traynor, D., Basse, N., Kay, R. R. & Warren, A. J. Defective ribosome assembly in Shwachman-Diamond syndrome. Blood 118, 4305-12 (2011). 2180384821803848
1008RPL8ARP40215_T100Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxing Dictyostelium. J Cell Sci. 131, NULL (2018). 2961863229618632
1009RPN2ARP45400_P050Expression of ribophorine II is a promising prognostic factor in human gastric adenocarcinoma. Int. J. Oncol. 50, 448-456 (2017). 2803535228035352
1010RPS16ARP33535_T100Okada, K. et al. Expression analysis of MIF4GD in the rat testis. J. Reprod. Dev. 57, 256-61 (2011). 2115712221157122
1011RPS16ARP33535_T100Sugihara, Y. et al. Identification and expression of an autosomal paralogue of ribosomal protein S4, X-linked, in mice: potential involvement of testis-specific ribosomal proteins in translation and spermatogenesis. Gene 521, 91-9 (2013). 2350059223500592
1012RPS28ARP65601_P050A tRNA-Derived Small RNA Regulates Ribosomal Protein S28 Protein Levels after Translation Initiation in Humans and Mice. Cell Rep. 29, 3816-3824.e4 (2019). 3185191531851915
1013RPS6KA2ARP56170_P050Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism. iScience 104823 25 8 August 202235992092
1014RPS6KB1OAAF07416Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment. iScience. 24, 103497 (2021). 3493491934934919
1015RRP1ARP45812_P050Spellman, C., Ahmed, M. M., Dubach, D. & Gardiner, K. J. Expression of trisomic proteins in Down syndrome model systems. Gene 512, 219-225 (2013). 2310382823103828
1016RTN3OABB01421Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain. Dev Neurosci. 40, 325-336 (2018). 3039961030399610
1017RUNX2OALA04014RUNX2 controls human IPO8 basal transcription in Saos-2 cells. Mol Med Rep. 14, 1418-24 (2016). 2727797027277970
1018RUVBL2ARP32379_P050Barthéléry, M., Jaishankar, A., Salli, U. & Vrana, K. E. Reptin52 expression during in vitro neural differentiation of human embryonic stem cells. Neurosci. Lett. 452, 47-51 (2009). 1944495119444951
1019S1PR5ARP42661_T100Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells. J. Dermatol. Sci. 82, 9-17 (2016). 2680322626803226
1020SARDHARP42344_T100Khan, A. P. et al. The role of sarcosine metabolism in prostate cancer progression. Neoplasia 15, 491-501 (2013). 2363392123633921
1021SART3ARP39128_T100Cellular Immune Responses for Squamous Cell Carcinoma Antigen Recognized by T Cells 3 in Patients with Hepatocellular Carcinoma. PLoS ONE. 12, e0170291 (2017). 2811442428114424
1022SBDSARP45719_T100Sezgin, G. et al. Impaired growth, hematopoietic colony formation, and ribosome maturation in human cells depleted of Shwachman-Diamond syndrome protein SBDS. Pediatr. Blood Cancer 60, 281-6 (2013). 2299714822997148
1023SCARB1ARP63158_P050Fu, Y. et al. ABCA12 Regulates ABCA1-Dependent Cholesterol Efflux from Macrophages and the Development of Atherosclerosis. Cell Metab. 18, 225-38 (2013). 2393175423931754
1024SCN5ARP34934_P050Matsushita, N. et al. Nicorandil improves electrical remodelling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy. Clin. Exp. Pharmacol. Physiol. 41, 89-97 (2014). 2411787624117876
1025SCXAOAAB00449The effects of scaffold architecture and fibrin gel addition on tendon cell phenotype. J Mater Sci Mater Med. 26, 5349 (2015) 2557870325578703
1026SERPINA1OABB01837Human Urinary Epithelial Cells as a Source of Engraftable Hepatocyte-Like Cells Using Stem Cell Technology. Cell Transplant. 25, 2221-2243 (2016). 2751297927512979
1027SERPINB5ARP42055_T100Mardin, W. A. et al. SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma. BMC Cancer 10, 549 (2010). 2093987920939879
1028SERPINB5ARP42055_T100Hrabakova, R. et al. Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy. J. Proteome Res. 12, 455-69 (2013). 2315123123151231
1029SERPINB5ARP42055_T100SERPINB5 Promoter Hypomethylation Differentiates Pancreatic Ductal Adenocarcinoma From Pancreatitis. Pancreas. 45, 743-7 (2016). 2664627526646275
1030SERPINH1OACA06643Baseline Clinical and Biomarker Characteristics of Biobank Innovations for Chronic Cerebrovascular Disease With Alzheimer's Disease Study: BICWALZS. Psychiatry Investig. (2022). 3504228335042283
1031SERTAD1ARP34309_T100Sertad1 Induces Neurological Injury after Ischemic Stroke via the CDK4/p-Rb Pathway. Mol Cells. (2022). 3501462035014620
1032SetD2ARP47617_T100Barrand, S., Andersen, I. S. & Collas, P. Promoter-exon relationship of H3 lysine 9, 27, 36 and 79 methylation on pluripotency-associated genes. Biochem. Biophys. Res. Commun. 401, 611-7 (2010). 2092047520920475
1033SETD2ARP47617_T100Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet. 46, 287-93 (2014). 2450947724509477
1034SF1ARP41214_T100Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1. Genes Cells. 19, 704-21 (2014). 2514526425145264
1035SFRS1ARP40691_P050Li, J. et al. A strategy to rapidly identify the functional targets of microRNAs by combining bioinformatics and mRNA cytoplasmic/nucleic ratios in culture cells. FEBS Lett. 584, 3198-202 (2010). 2054715820547158
1036SFRS10ARP40528_T100Fu, K. et al. Tra2beta protein is required for tissue-specific splicing of a smooth muscle myosin phosphatase targeting subunit alternative exon. J. Biol. Chem. 287, 16575-85 (2012). 2243783122437831
1037SGPP2ARP45734_T100Rajkumar Vutukuri, et al. Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption. 172-185 (2018). 2902371129023711
1038SHHARP44235_P050Stage-Specific Effect of Inositol Hexaphosphate on Cancer Stem Cell Pool during Growth and Progression of Prostate Tumorigenesis in TRAMP Model. Cancers (Basel) NULL 14 17 August 202236077751
1039SIGLEC1OASA04956Mouse Siglec-1 Mediates trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner. J Biol Chem. 290, 27345-59 (2015). 2637007426370074
1040SIM1ARP33296_P050Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development. Dev Biol. 413, 86-103 (2016) 2618719926187199
1041SIP1ARP39141_P050Regulation of trunk neural crest delamination by dEF1 and Sip1 in the chicken embryo. Dev. Growth Differ. 58, 205-14 (2016). 2669143826691438
1042SIRT3ARP32389_P050Lanza, I. R. et al. Endurance exercise as a countermeasure for aging. Diabetes 57, 2933-42 (2008). 1871604418716044
1043SIRT3ARP32389_P050Dong, R. et al. Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures. Cell. Immunol. 272, 1-10 (2011). 2208728722087287
1044SIRT3ARP32389_P050Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas. Sci Adv. 2, e1601132 (2016). 2784786927847869
1045SIX1ARP32375_P050Lee, S. H. et al. Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. J. Mol. Cell. Cardiol. 52, 718-26 (2012). 2219730922197309
1046SLC10A2OAEB00210Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Mol Metab. 11, 84-95 (2018). 2965610929656109
1047SLC12A1OABB01331"Reversed polarization" of Na/K-ATPase-a sign of inverted transport in the human endolymphatic sac: a super-resolution structured illumination microscopy (SR-SIM) study. Cell Tissue Res. 379, 445-457 (2020). 3171372631713726
1048SLC12A2OABB01332Impaired glucose tolerance, glucagon, and insulin responses in mice lacking the loop diuretic-sensitive Nkcc2a transporter. Am J Physiol Cell Physiol. 317, C843-C856 (2019). 3136529531365295
1049SLC12A5OASE00240Pharmaco-resistant Neonatal Seizures: Critical Mechanistic Insights from a Chemoconvulsant Model. Dev Neurobiol. 78, 1117-1130 (2018). 3013637330136373
1050SLC12A5OASE00240TrkB agonists prevent postischemic emergence of refractory neonatal seizures in mice. JCI Insight. 5, NULL (2020). 3242758532427585
1051SLC19A1ARP44167_T100Marchi, E. et al. Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies. Clin. Cancer Res. 16, 3648-58 (2010). 2050161620501616
1052SLC19A1ARP44167_T100Halwachs, S., Lakoma, C., Schäfer, I., Seibel, P. & Honscha, W. The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier. Mol. Pharmacol. 80, 621-9 (2011). 2173757121737571
1053SLC1A4OAAN01042Poly(I:C) alters placental and fetal brain amino acid transport in a rat model of maternal immune activation. Am J Reprod Immunol e13115 81 6 June 201930924965
1054SLC1A5ARP42247_T100Zhu, Y. et al. L-Glutamine deprivation induces autophagy and alters the mTOR and MAPK signaling pathways in porcine intestinal epithelial cells. Amino Acids (2014). doi:10.1007/s00726-014-1785-0 2499716224997162
1055SLC1A5ARP42247_T100Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature. 532, 389-93 (2016). 2706490327064903
1056SLC1A5ARP42247_T100Protein Restriction with Amino Acid-Balanced Diets Shrinks Circulating Pool Size of Amino Acid by Decreasing Expression of Specific Transporters in the Small Intestine. PLoS ONE. 11, e0162475 (2016). 2761130727611307
1057SLC22A1ARP41516_T100Expression of choline and acetylcholine transporters in synovial tissue and cartilage of patients with rheumatoid arthritis and osteoarthritis. Cell Tissue Res. 359, 465-477 (2015). 2541813625418136
1058SLC22A1ARP41640_T100Salomon, J. J. et al. The Cell Line NCl-H441 Is a Useful in Vitro Model for Transport Studies of Human Distal Lung Epithelial Barrier. Mol. Pharm. (2014). doi:10.1021/mp4006536 2452436524524365
1059SLC22A16ARP33061_T100Hashimoto, Y. et al. Expression of organic anion-transporting polypeptide 1A2 and organic cation transporter 6 as a predictor of pathologic response to neoadjuvant chemotherapy in triple negative breast cancer. Breast Cancer Res. Treat. 145, 101-11 (2014). 2467135724671357
1060SLC22A17OAEB00639Expression of uterine lipocalin 2 and its receptor during early- to mid-pregnancy period in mares. J. Reprod. Dev. (2016). 2798023627980236
1061SLC23A1OAAB09000Limited Association Between Ascorbate Concentrations and Vitamin C Transporters in Renal Cell Carcinoma Cells and Clinical Samples. Cell Physiol Biochem. 55, 553-568 (2021). 3459965034599650
1062SLC26A4ARP41739_P050Urinary Extracellular Vesicles for Renal Tubular Transporters Expression in Patients With Gitelman Syndrome. Front Med (Lausanne). 8, 679171 (2021) 3417904734179047
1063SLC27A6ARP43781_P050Gaccioli, F. et al. Maternal overweight induced by a diet with high content of saturated fat activates placental mTOR and eIF2 alpha signaling and increases fetal growth in rats. Biol. Reprod. 89, 96 (2013). 2400627924006279
1064SLC29A2ARP43822_T100Okuda, H., Higashi, Y., Nishida, K., Fujimoto, S. & Nagasawa, K. Contribution of P2X7 receptors to adenosine uptake by cultured mouse astrocytes. Glia 58, 1757-65 (2010). 2064541320645413
1065SLC34A3ARP32173_P050Impact of Pals1 on Expression and Localization of Transporters Belonging to the Solute Carrier Family. Front Mol Biosci 2022 NULL 9 792829 3525234935252349
1066SLC38A2ARP33059_P050Intermittent Bolus Compared With Continuous Feeding Enhances Insulin and Amino Acid Signaling to Translation Initiation in Skeletal Muscle of Neonatal Pigs. J Nutr 2021 9 151 2636-2645 3415936834159368
1067SLC39A6ARP43931_T100Trokovic, N. et al. Exosomal secretion of death bullets: a new way of apoptotic escape? Am. J. Physiol. Endocrinol. Metab. 303, E1015-24 (2012). 2291236522912365
1068SLC3A2OASA02585Quantitative Algorithm-Based Paired Imaging Measurement for Antibody-Triggered Endocytosis in Cultured Cells. SLAS Discov. 23, 832-841 (2018). 2950573529505735
1069SLC3A2OAAB00158Decrease of Intracellular Glutamine by STF-62247 Results in the Accumulation of Lipid Droplets in von Hippel-Lindau Deficient Cells. Front Oncol 2022 NULL 12 841054 3522352235223522
1070SLC44A2ARP44009_P050The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function. Nat Commun. 11, 3479 (2020). 3266125032661250
1071SLC47A2ARP51904_P050Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier. Drug Metab Dispos 2022 6 50 770-780 3530765135307651
1072SLC5A8OABF01657Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats. Acta Physiol (Oxf). 226, e13256 (2019). 3065683530656835
1073Slc6a9ARP42330_P050Poly(I:C) alters placental and fetal brain amino acid transport in a rat model of maternal immune activation. Am J Reprod Immunol e13115 81 6 June 201930924965
1074Slc7a3ARP43806_P050FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. Mol Psychiatry 2021 11 26 6845-6867 3386399533863995
1075SLPIOAPB00538MyD88 deficiency alters expression of antimicrobial factors in mouse salivary glands. PLoS One. 9, e113333 (2014). 2541541925415419
1076SMAD3OAAB06596Uchiyama, Y. et al. SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc. J. Bone Miner. Res. 23, 1619-28 (2008). 1846607318466073
1077SMPDL3BARP33875_P050Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages. J Biol Chem. 289, 32895-913 (2014). 2528878925288789
1078SNAI1ARP33314_P050Wang, H. et al. PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. Cancer Res. 67, 2922-6 (2007). 1740939517409395
1079SNAI1ARP33314_P050Surati, M. et al. Proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database. J. Clin. Bioinforma. 1, 1-11 (2011). 2160312121603121
1080SNAI1ARP33314_P050Cooper, C. D. O. et al. Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens. PLoS One 6, e23916 (2011). 2191417221914172
1081SNRP70ARP40275_P050Wang, E. & Cambi, F. Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs. J. Biol. Chem. 284, 11194-204 (2009). 1924423619244236
1082SNRP70ARP40439_P050Franklin, S. et al. Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy. Mol. Cell. Proteomics 10, M110.000703 (2011). 2080783520807835
1083SNRP70ARP40439_P050Serini, S. et al. DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and beta-catenin nuclear translocation. Carcinogenesis 33, 164-73 (2012). 2204502422045024
1084SNRP70ARP40439_P050Franklin, S. et al. Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. Mol. Cell. Proteomics 11, M111.014258 (2012). 2227000022270000
1085SNRPAARP40531_P050Wang, E. & Cambi, F. Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs. J. Biol. Chem. 284, 11194-204 (2009). 1924423619244236
1086SOCS2ARP63434_P050The Role of GLP1 in Rat Steatotic and Non-Steatotic Liver Transplantation from Cardiocirculatory Death Donors. Cells 2019 12 8 NULL 3183541031835410
1087SOD1OASE00355PYP1-4 peptide from Pyropia yezoensis protects against acetaminophen-induced hepatotoxicity in HepG2 cells. Exp Ther Med. 19, 849-860 (2020). 3201024532010245
1088SOD2OASE00357Identification and antioxidant activity of synthetic peptides from phycobiliproteins of Pyropia yezoensis. Int J Mol Med. 42, 789-798 (2018). 2971777129717771
1089SOD2OASE00357PYP1-4 peptide from Pyropia yezoensis protects against acetaminophen-induced hepatotoxicity in HepG2 cells. Exp Ther Med. 19, 849-860 (2020). 3201024532010245
1090SOX10ARP33326_P050Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation. J Neurosci. 35, 352-65 (2015). 2556812725568127
1091SOX10ARP33326_P050SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. Sci Rep. 6, 17735 (2016). 2678755826787558
1092SOX10ARP33326_P050Anti-epileptic drug topiramate upregulates TGFβ1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity. PLoS One 2021 2 16 e0246989 3357755433577554
1093SOX17ARP39552_P050Kallas, A., Pook, M., Trei, A. & Maimets, T. SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate. Stem Cells Int. 2014, 298163 (2014). 2470729624707296
1094SOX17ARP39552_P050Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations. JCI Insight 2022 11 7 NULL 3551143535511435
1095SOX18ARP33056_P050Duong, T. et al. Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice. Cancer Res. 72, 3105-14 (2012). 2252303422523034
1096SOX18ARP33056_P050Deng, Y., Atri, D., Eichmann, A. & Simons, M. Endothelial ERK signaling controls lymphatic fate specification. J. Clin. Invest. 123, 1202-15 (2013). 2339172223391722
1097Sox18ARP33056_P050Park, D.-Y. et al. Lymphatic regulator PROX1 determines Schlemm canal integrity and identity. J. Clin. Invest. 124, 3960-3974 (2014). 2506187725061877
1098SOX2ARP31737_P050Perry, K. J., Thomas, A. G. & Henry, J. J. Expression of pluripotency factors in larval epithelia of the frog Xenopus: evidence for the presence of cornea epithelial stem cells. Dev. Biol. 374, 281-94 (2013). 2327442023274420
1099SOX4ARP38234_P050STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4. Mol Cancer. 16, 136 (2017). 2881092728810927
1100SOX5ARP33323_P050A Novel Method to Induce Cartilage Regeneration with Cubic Microcartilage. Cells Tissues Organs 251-260 204 44687 October 201728972948
1101Sox9OAAF00840Ferrand, N. et al. Loss of WISP2/CCN5 in estrogen-dependent MCF7 human breast cancer cells promotes a stem-like cell phenotype. PLoS One 9, e87878 (2014). 2449838824498388
1102SOX9OAAF00840Kallas, A., Pook, M., Trei, A. & Maimets, T. SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate. Stem Cells Int. 2014, 298163 (2014). 2470729624707296
1103SPAG9OAAB04262Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer. Oncotarget. 7, 72845-72859 (2016). 2765571427655714
1104SPARCARP63168_P050SPARC overexpression combined with radiation retards angiogenesis by suppressing VEGF-A via miR‑410 in human neuroblastoma cells. Int. J. Oncol. 49, 1394-406 (2016). 2749884027498840
1105SPPL2bARP44989_P050Del Campo, M. et al. BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer’s disease. Neurobiol. Aging 35, 1596-604 (2014). 2452496324524963
1106SRFOAAF00701Myc requires RhoA/SRF to reprogram glutamine metabolism. Small GTPases. 1-9 (2016). 2753220927532209
1107SRP19ARP40456_T100Arana-Argáez, V. E. et al. Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells. J. Biol. Chem. 285, 32824-33 (2010). 2072921320729213
1108STAT1ARP38933_P050Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis. Int J Clin Exp Pathol. 8, 10555-64 (2015). 2661776526617765
1109STAT3ARP38253_P050Deng, W. et al. Bone marrow mesenchymal stromal cells with support of bispecific antibody and ultrasound-mediated microbubbles prevent myocardial fibrosis via the signal transducer and activators of transcription signaling pathway. Cytotherapy 13, 431-40 (2011). 2117448921174489
1110STAT3ARP38253_P050Vega, V. L. et al. Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression. J. Mol. Med. (Berl). doi:10.1007/s00109-014-1201-y (2014). 2516376425163764
1111STAT3ARP38253_P050Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis. Int J Clin Exp Pathol. 8, 10555-64 (2015). 2661776526617765
1112STAT3AVARP09057_P050Tissue-specific transcription profile of cytokine and chemokine genes associated with flavivirus control and non-lethal neuropathogenesis in rabbits. Virology. 494, 1-14 (2016). 2706105227061052
1113SULT1A1ARP49134_P050Yalcin, E. B. et al. Downregulation of sulfotransferase expression and activity in diseased human livers. Drug Metab. Dispos. 41, 1642-50 (2013). 2377584923775849
1114SUV39H1ARP32470_T100Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1. Diabetes. 59, 2904-15 (2010). 2069941920699419
1115SUV420H1ARP34567_P050Gatta, R. & Mantovani, R. NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations. Nucleic Acids Res. 36, 6592-607 (2008). 1894086818940868
1116SUV420H1ARP34567_P050Murata, T. et al. Epigenetic histone modification of Epstein-Barr virus BZLF1 promoter during latency and reactivation in Raji cells. J. Virol. 86, 4752-61 (2012). 2235727222357272
1117SVCT1OAAB09000Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice. Free Radic. Biol. Med. 99, 451-462 (2016). 2756753927567539
1118SYNGR4OAPB01027Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models. Hum Mol Genet. 29, 2647-2661 (2020). 3268683532686835
1119SYPARP45435_P050Stenkamp-Strahm, C. M., Kappmeyer, A. J., Schmalz, J. T., Gericke, M. & Balemba, O. High-fat diet ingestion correlates with neuropathy in the duodenum myenteric plexus of obese mice with symptoms of type 2 diabetes. Cell Tissue Res. 354, 381-94 (2013). 2388140423881404
1120SYPARP45435_P050TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis. Elife. 10, NULL (2021) 3456993034569930
1121SYT13OAAB02896Amido-Bridged Nucleic Acid-Modified Antisense Oligonucleotides Targeting SYT13 to Treat Peritoneal Metastasis of Gastric Cancer. Mol Ther Nucleic Acids. 22, 791-802 (2020). 3323047633230476
1122SYT13OAAB02896Synaptotagmin 13 Is Highly Expressed in Estrogen Receptor-Positive Breast Cancer. Curr Oncol. 28, 4080-4092 (2021). 3467726434677264
1123SYT7OASE00272CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers. Mol Cell Biol. 39, (2019). 3118264131182641
1124TAF15ARP30112_P050Ko, S. Y., Lengyel, E. & Naora, H. The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions. Mol. Cell. Endocrinol. 317, 112-9 (2010). 2004808220048082
1125TARDBPARP35837_P050LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance. Mol Cell. 48, 195-206 (2012). 2295927522959275
1126TARDBPARP35838_P050Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death. Acta Neuropathol. 130, 49-61 (2015). 2578835725788357
1127TARDBPARP38941_T100Estes, P. S. et al. Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. Hum. Mol. Genet. 20, 2308-21 (2011). 2144156821441568
1128TARDBPARP38942_T100Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation. Biomolecules. 10, (2020). 3299290132992901
1129TARDBPARP38941_T100Frontotemporal Lobar Degeneration Case with an N-Terminal TUBA4A Mutation Exhibits Reduced TUBA4A Levels in the Brain and TDP-43 Pathology. Biomolecules 2022 3 12 NULL 3532763235327632
1130TAZOAAB05400Ciavarella, S., Dammacco, F., De Matteo, M., Loverro, G. & Silvestris, F. Umbilical cord mesenchymal stem cells: role of regulatory genes in their differentiation to osteoblasts. Stem Cells Dev. 18, 1211-20 (2009). 1912562319125623
1131TBX15ARP47723_T100Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach. Clin Epigenetics. 7, 86 (2015). 2630099126300991
1132TBX5ARP33403_P050Lu, J. et al. Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos. J. Biomed. Sci. 18, 73 (2011). 2198217821982178
1133TBX5ARP33403_P050Zhang, Y., Huang, L., Zuo, Z., Chen, Y. & Wang, C. Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. Aquat. Toxicol. 142-143, 26-32 (2013). 2394807523948075
1134TBX5ARP33403_P050Baban, A. et al. Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: functional characterization of a de novo TBX5 mutation. Am. J. Med. Genet. A 164A, 1419-24 (2014). 2466449824664498
1135TBX5ARP33403_P050The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation. Dev Cell. 36, 262-75 (2016). 2685935126859351
1136TBX6ARP33405_P050Leschik, J., Stefanovic, S., Brinon, B. & Pucéat, M. Cardiac commitment of primate embryonic stem cells. Nat. Protoc. 3, 1381-7 (2008). 1877286418772864
1137TBX6ARP33405_P050Chen, Y.-L. et al. Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation. J. Biol. Chem. 284, 23481-90 (2009). 1956107519561075
1138TBX6ARP33405_T100Cardiac commitment of primate embryonic stem cells. Nat Protoc 1381-7 3 9 September 200818772864
1139TDP2ARP33010_P050Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. 45, 1159-1176 (2017). 2818030028180300
1140TDP43ARP38942_T100Bannister, J. P. et al. Ca(V)1.2 channel N-terminal splice variants modulate functional surface expression in resistance size artery smooth muscle cells. J. Biol. Chem. 286, 15058-66 (2011). 2135864321358643
1141TEAD1ARP39521_P050Ribas, R. et al. Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments. Dev. Biol. 355, 372-80 (2011). 2152725821527258
1142TEAD4ARP38276_P050Ribas, R. et al. Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments. Dev. Biol. 355, 372-80 (2011). 2152725821527258
1143TEAD4ARP38276_P050Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model. Mol Cell Biol. 34, 1607-21 (2014). 2455000724550007
1144TEAD4ARP38276_P050Identification of Quinolinols as Activators of TEAD-Dependent Transcription. ACS Chem Biol. 14, 2909-2921 (2019). 3174299531742995
1145TEAD4ARP38276_P050Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 36, 109347 (2021) 3426091634260916
1146TecrlARP44592_P050TECRL deficiency results in aberrant mitochondrial function in cardiomyocytes. Commun Biol 470 5 1 May 202235577932
1147TET2OAEB00839Reduction of global 5-hydroxymethylcytosine is a poor prognostic factor in breast cancer patients, especially for an ER/PR-negative subtype. Breast Cancer Res. Treat. 153, 219-34 (2015). 2625394526253945
1148TET2OAEB00839Ten-eleven translocation 1 dysfunction reduces 5-hydroxymethylcytosine expression levels in gastric cancer cells. Oncol Lett. 15, 278-284 (2018). 2928519229285192
1149TFOASG07301Endogenous morphine in SH-SY5Y cells and the mouse cerebellum. PLoS One. 3, e1641 (2008) 1832729318327293
1150TFAMOAAB00276miR-504 mediated down-regulation of nuclear respiratory factor 1 leads to radio-resistance in nasopharyngeal carcinoma. Oncotarget. 6, 15995-6018 (2015). 2620144626201446
1151TFAMARP36992_P050TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A. Nat Commun 2022 1 13 653 3511552735115527
1152TfamARP36993_P050Propionate alleviates fatty acid-induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes. J Dairy Sci 2022 NULL NULL NULL 3518112935181129
1153TFAP2AOAAF01732Li, J. et al. A strategy to rapidly identify the functional targets of microRNAs by combining bioinformatics and mRNA cytoplasmic/nucleic ratios in culture cells. FEBS Lett. 584, 3198-202 (2010). 2054715820547158
1154TFCP2L1OAAB09732The CDK1/TFCP2L1/ID2 cascade offers a novel combination therapy strategy in a preclinical model of bladder cancer. Exp Mol Med 2022 6 54 801-811 3572932535729325
1155TGOPSA10707Characterization of Regulatory B Cells in Graves' Disease and Hashimoto's Thyroiditis. PLoS One 2015 5 10 e0127949 2601695426016954
1156TGFBR1OAAI00768Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. J Clin Invest. 127, 321-334 (2017). 2786965127869651
1157TGFBR1OAAI00768Phenotypic characterization of adenomyosis occurring at the inner and outer myometrium. PLoS One. 12, e0189522 (2017). 2925301029253010
1158TGFBR1OAAI00768A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing. Nat Commun. 12, 1670 (2021) 3372326733723267
1159TGFBR1OAAI00768Disulfiram Sensitizes a Therapeutic-Resistant Glioblastoma to the TGF-β Receptor Inhibitor. Int J Mol Sci 2021 19 22 NULL 3463884234638842
1160TGM2OAAF01946Physiological, pathological, and structural implications of non-enzymatic protein-protein interactions of the multifunctional human transglutaminase 2. Cell. Mol. Life Sci. 72, 3009-35 (2015). 2594330625943306
1161THIK-1ARP35347_P050Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage. Biochim. Biophys. Acta. 1863, 2766-2783 (2016). 2756629227566292
1162Thoc4ARP43055_T100Ding, D., Enriquez-Algeciras, M., Dave, K. R., Perez-Pinzon, M. & Bhattacharya, S. K. The role of deimination in ATP5b mRNA transport in a transgenic mouse model of multiple sclerosis. EMBO Rep. 13, 230-6 (2012). 2226171622261716
1163TLR2ARP30551_P050Expression of Toll-like receptors 2, 4 and 6 in equine endometrial epithelial cells: A comparative in situ and in vitro study. Res. Vet. Sci. 112, 34-41 (2017). 2811916128119161
1164TLR2ARP30551_P050Expression of Toll-like receptors 2, 4 and 6 in different cell populations of the equine endometrium. Vet. Immunol. Immunopathol. 185, 7-13 (2017). 2824200428242004
1165TM9SF1ARP44683_T100He, P. et al. High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene. Autophagy 5, 52-60 (2009). 1902983319029833
1166TM9SF1ARP44683_T100Extracellular vesicle-mediated EBAG9 transfer from cancer cells to tumor microenvironment promotes immune escape and tumor progression. Oncogenesis. 7, 7 (2018). 2936244829362448
1167TMEM135ARP49773_P050Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. Elife. 5, (2016). 2786320927863209
1168TMTC2ARP49065_P050TRAIL sensitivity of nasopharyngeal cancer cells involves redox dependent upregulation of TMTC2 and its interaction with membrane caspase-3. Redox Biol 2021 NULL 48 102193 3483914234839142
1169TNNI1ARP42117_P050Myostatin deficiency but not anti-myostatin blockade induces marked proteomic changes in mouse skeletal muscle. Proteomics. 16, 2019-27 (2016). 2721482427214824
1170TNNI3ARP41391_P050Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations. Circ Res. 124, 1228-1239 (2019). 3073253230732532
1171TNRC5ARP34422_P050The whole-genome expression analysis of peripheral blood mononuclear cells from aspirin sensitive asthmatics versus aspirin tolerant patients and healthy donors after in vitro aspirin challenge. Respir. Res. 16, 147 (2015). 2664671926646719
1172TNS1OAEB00321Gonadotropin-releasing hormone agonist induces downregulation of tensin 1 in women with endometriosis. Acta Obstet Gynecol Scand. 98, 222-231 (2019) 3031248630312486
1173TPM2ARP48224_T100Abdul-Hussein, S., Rahl, K., Moslemi, A.-R. & Tajsharghi, H. Phenotypes of myopathy-related beta-tropomyosin mutants in human and mouse tissue cultures. PLoS One 8, e72396 (2013). 2403975724039757
1174TRIM32ARP31692_P050Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component. Hum Mol Genet. 18, 1353-67 (2009). 1915521019155210
1175TRIM65OAAB08057LncRNA LINC00963 promotes colorectal cancer cell proliferation and metastasis by regulating miR‑1281 and TRIM65. Mol Med Rep. 24 (2021). 3449870634498706
1176TRIM72OAEB00972Lack of MG53 in human heart precludes utility as a biomarker of myocardial injury or endogenous cardioprotective factor. Cardiovasc Res. 110, 178-87 (2016). 2679047626790476
1177TRPA1ARP35205_P050Rohn, T. T., Catlin, L. W., Coonse, K. G. & Habig, J. W. Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer’s disease brain. Brain Res. 1475, 106-15 (2012). 2290513422905134
1178TRPA1ARP35205_P050Pierce, A. N., Ryals, J. M., Wang, R. & Christianson, J. A. Vaginal hypersensitivity and hypothalamic-pituitary-adrenal axis dysfunction as a result of neonatal maternal separation in female mice. Neuroscience 263, 216-30 (2014). 2446260924462609
1179TRPA1ARP35205_P050TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress. Brain. 139, 1361-77 (2016). 2698418626984186
1180TRPA1ARP35205_P050TRPA1 receptor is upregulated in human oral lichen planus. Oral Dis. 23, 189-198 (2017). 2771829727718297
1181TRPA1ARP35205_P050TRPA1 mediates damage of the retina induced by ischemia and reperfusion in mice. Cell Death Dis. 11, 633 (2020). 3280131432801314
1182TRPA1ARP35205_P050Upregulation of extraneuronal TRPV1 expression in chronic rhinosinusitis with nasal polyps. Rhinology 2018 3 56 245-254 2947661629476616
1183TRPA1ARP35205_P050No functional TRPA1 in cardiomyocytes. Acta Physiol (Oxf) e13659 232 4 August 202133819369
1184TRPM2ARP44380_P050TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1. J Clin Invest. 124, 4989-5001 (2014). 2529553625295536
1185TRPM5ARP35242_P050The Role of Cholecystokinin in Peripheral Taste Signaling in Mice. Front Physiol. 8, 866 (2017). 2916320929163209
1186TRPV4ARP35416_P050Sampat, S. R. et al. Applied osmotic loading for promoting development of engineered cartilage. J. Biomech. 46, 2674-81 (2013). 2403501424035014
1187TSC22D4ARP30107_T100Canterini, S., Bosco, A., De Matteis, V., Mangia, F. & Fiorenza, M. T. THG-1pit moves to nucleus at the onset of cerebellar granule neurons apoptosis. Mol. Cell. Neurosci. 40, 249-57 (2009). 1908460119084601
1188TSC22D4ARP30107_T100Canterini, S. et al. Subcellular TSC22D4 localization in cerebellum granule neurons of the mouse depends on development and differentiation. Cerebellum 11, 28-40 (2012). 2087829620878296
1189TSC22D4ARP30107_T100NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation. Cell Rep. 30, 3478-3491.e6 (2020). 3216055132160551
1190TSC22D4ARP37339_T100Canterini, S., Carletti, V., Nusca, S., Mangia, F. & Fiorenza, M. T. Multiple TSC22D4 iso-/phospho-glycoforms display idiosyncratic subcellular localizations and interacting protein partners. FEBS J. 280, 1320-9 (2013). 2330524423305244
1191TSC22D4ARP37339_T100GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance. Development. 145, (2018). 3012690430126904
1192TSG101ARP37310_T100Isolation of Exosomes and Microvesicles from Cell Culture Systems to Study Prion Transmission. Methods Mol. Biol. 1545, 153-176 (2017). 2794321327943213
1193TSPOOALA05219Organoid-derived C-Kit+/SSEA4- human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents. Nat Commun. 10, 1205 (2019). 3087257830872578
1194TTKOAAF01564Targeting dual specificity protein kinase TTK attenuates tumorigenesis of glioblastoma. Oncotarget. 9, 3081-3088 (2018). 2942303029423030
1195TTRAPARP33010_P050Xu, G.-L. et al. TTRAP is a novel PML nuclear bodies-associated protein. Biochem. Biophys. Res. Commun. 375, 395-8 (2008). 1870688518706885
1196TTRAPARP33010_P050Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. (2016). 2778968827789688
1197TTYH3ARP49946_P050TTYH3 Modulates Bladder Cancer Proliferation and Metastasis via FGFR1/H-Ras/A-Raf/MEK/ERK Pathway. Int J Mol Sci NULL 23 18 September 202236142409
1198TUBB2AARP40177_P050Crystal Structure of the SPOC Domain of the Arabidopsis Flowering Regulator FPA. PLoS ONE. 11, e0160694 (2016). 2751386727513867
1199TWIST1ARP37997_T100Guha, P. et al. Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, a9 nicotinic acetylcholine receptor and STAT3. Breast Cancer Res. Treat. 145, 5-22 (2014). 2466850024668500
1200TWIST1ARP37997_T100Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 26, 222-34 (2014). 2511771025117710
1201TYR1ARP44315_P050Horibe, I. et al. Induction of melanogenesis by 4’-O-methylated flavonoids in B16F10 melanoma cells. J. Nat. Med. 67, 705-10 (2013). 2320877123208771
1202U1AARP40275_P050Wang, E., Mueller, W. F., Hertel, K. J. & Cambi, F. G Run-mediated recognition of proteolipid protein and DM20 5’ splice sites by U1 small nuclear RNA is regulated by context and proximity to the splice site. J. Biol. Chem. 286, 4059-71 (2011). 2112706421127064
1203UBE2E1ARP43012_P050Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1. Elife 2022 NULL 11 NULL 3517042735170427
1204UBE2E2ARP43437_P050Hans, F. et al. UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination. J. Biol. Chem. 289, 19164-79 (2014). 2482590524825905
1205Ube2nARP34089_T100Xu, B. J. et al. Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts. Proteomics 10, 2458-70 (2010). 2040547720405477
1206UBE2TARP43145_P050CaMKII-δ9 Induces Cardiomyocyte Death to Promote Cardiomyopathy and Heart Failure. Front Cardiovasc Med 2022 NULL 8 820416 3512787435127874
1207ULK1OABF01248The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples. Nutrients. 12, (2020). 3212115432121154
1208ULK1OABF01248Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis. Autophagy. NULL, 1-17 (2020). 3307865433078654
1209ULK1OABF01248Genetic deletion of IL-6 increases CK-MB, a classic cardiac damage marker, and decreases UPRmt genes after exhaustive exercise. Cell Biochem Funct 369-378 40 4 June 202235411956
1210ULK1OABF01248Chronic rapamycin treatment decreases hepatic IL-6 protein, but increases autophagy markers as a protective effect against the overtraining-induced tissue damage. Clin Exp Pharmacol Physiol 893-902 49 8 August 202235637552
1211UPF3BARP40998_T100RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis. Sci Rep. 7, 41517 (2017). 2812834328128343
1212UPF3BARP40998_T100Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins. J Cell Sci. 130, 3009-3022 (2017). 2874373828743738
1213USE1ARP39361_P050Serologic markers of effective tumor immunity against chronic lymphocytic leukemia include nonmutated B-cell antigens. Cancer Res. 70, 1344-55 (2010). 2012448120124481
1214VARSARP46151_P050Duarte, M. & Videira, A. Defective valyl-tRNA synthetase hampers the mitochondrial respiratory chain in Neurospora crassa. Biochem. J. 448, 297-306 (2012). 2295769722957697
1215VDAC1ARP35122_T100Chen, S. et al. Reduced expression of lamin A/C results in modified cell signaling and metabolism coupled with changes in expression of structural proteins. J. Proteome Res. 8, 5196-211 (2009). 1977518919775189
1216VDAC1ARP35122_T100Arduíno, D. M. et al. Mitochondrial metabolism in Parkinson’s disease impairs quality control autophagy by hampering microtubule-dependent traffic. Hum. Mol. Genet. 21, 4680-702 (2012). 2284349622843496
1217VDAC1ARP35122_T100Rousset, F., Nguyen, M. V. C., Grange, L., Morel, F. & Lardy, B. Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes. PLoS One 8, e66478 (2013). 2384048323840483
1218VDAC2ARP35123_P050Hrabakova, R. et al. Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy. J. Proteome Res. 12, 455-69 (2013). 2315123123151231
1219VDAC3ARP35180_P050Majumder, S., Slabodnick, M., Pike, A., Marquardt, J. & Fisk, H. A. VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes. Cell Cycle 11, 3666-78 (2012). 2293571022935710
1220VDAC3ARP35180_P050Majumder, S. & Fisk, H. A. VDAC3 and Mps1 negatively regulate ciliogenesis. Cell Cycle 12, 849-58 (2013). 2338845423388454
1221VDAC3ARP35180_P050Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis. Cells. 4, 331-53 (2015). 2626402926264029
1222WASF3OAEC03197Li, J. et al. A strategy to rapidly identify the functional targets of microRNAs by combining bioinformatics and mRNA cytoplasmic/nucleic ratios in culture cells. FEBS Lett. 584, 3198-202 (2010). 2054715820547158
1223WDR45OAAB09622TRAPPC11 functions in autophagy by recruiting ATG2B-WIPI4/WDR45 to preautophagosomal membranes. Traffic 325-345 20 5 May 201930843302
1224Wnt2BARP41254_P050Chigita, S. et al. CD82 inhibits canonical Wnt signalling by controlling the cellular distribution of beta-catenin in carcinoma cells. Int. J. Oncol. 41, 2021-8 (2012). 2307698123076981
1225Wnt7bARP41291_P050Gore, A. J., Deitz, S. L., Palam, L. R., Craven, K. E. & Korc, M. Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-beta to promote proliferation. J. Clin. Invest. 124, 338-52 (2014). 2433445824334458
1226WT1OAAN00281Antileukaemic Cell Proliferation and Cytotoxic Activity of Edible Golden Cordyceps (Cordyceps militaris) Extracts. Evid Based Complement Alternat Med 2022 NULL 2022 5347718 3549791535497915
1227XDHOAAB05869Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult. J Physiol. 594, 1327-40 (2016). 2657416226574162
1228XPOTARP40711_P050The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. Elife. 10, NULL (2021) 3364611833646118
1229YAP1ARP50530_P050Allelic Expression Imbalance Analysis Identified YAP1 Amplification in p53- Dependent Osteosarcoma. Cancers (Basel). 13 (2021). 3380351233803512
1230YTHDF2ARP67917_P050The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells. Cancer Discov 2021 2 11 480-499 3302389233023892
1231ZBTB32OACA06573ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation. iScience 2021 7 24 102790 3433736134337361
1232Zbtb43ARP39048_P050Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome. Nat Cell Biol 1141-1153 24 7 July 202235787683
1233ZEB1ARP30976_P050Li, J. et al. A strategy to rapidly identify the functional targets of microRNAs by combining bioinformatics and mRNA cytoplasmic/nucleic ratios in culture cells. FEBS Lett. 584, 3198-202 (2010). 2054715820547158
1234ZEB2ARP39141_P050Rogers, C. D., Saxena, A. & Bronner, M. E. Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT. J. Cell Biol. 203, 835-47 (2013). 2429775124297751
1235ZEB2ARP39141_P050Guan, H. et al. Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2. Endocrine. doi:10.1007/s12020-014-0326-7 (2014). 2496873524968735
1236ZFP191ARP33519_P050Lv, L. et al. Zinc finger protein 191 deficiency attenuates vascular smooth muscle cell proliferation, migration, and intimal hyperplasia after endovascular arterial injury. J. Vasc. Surg. (2013). doi:10.1016/j.jvs.2013.03.049 2375597523755975
1237ZFXARP33498_P050Zha, W., Cao, L., Shen, Y. & Huang, M. Roles of Mir-144-ZFX pathway in growth regulation of non-small-cell lung cancer. PLoS One 8, e74175 (2013). 2406611624066116
1238ZIC2ARP35821_P050Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2. Oncotarget. 6, 28257-68 (2015). 2631804526318045
1239ZIC2ARP35821_P050ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. J. Clin. Invest. 125, 3795-808 (2015). 2642607826426078
1240ZIC2ARP35821_P050The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1. J Biol Chem. 293, 7982-7992 (2018). 2958836629588366
1241ZIC5OAEB00858AR-regulated ZIC5 contributes to the aggressiveness of prostate cancer. Cell Death Discov 393 8 1 September 202236127329
1242ZIP5ARP44143_P050Zinc Transport Differs in Rat Spermatogenic Cell Types and Is Affected by Treatment with Cyclophosphamide. Biol. Reprod. 95, 22 (2016). 2728170827281708
1243ZNF142ARP38554_P050AMP-Activated Protein Kinase Regulates the Cell Surface Proteome and Integrin Membrane Traffic. PLoS ONE. 10, e0128013 (2015). 2601009426010094
1244ZNF230ARP34554_P050Liu, Y. et al. A new mutant transcript generated in Znf230 exon 2 knockout mice reveals a potential exon structure in the targeting vector sequence. Acta Biochim. Biophys. Sin. (Shanghai). 45, 123-8 (2013). 2319613423196134
1245ZNF318ARP32523_P050Rad52 mediates class-switch DNA recombination to IgD. Nat Commun 2022 1 13 980 3519053135190531
1246ZNF384OACA04063ZNF384-fusion proteins have high affinity for the transcriptional coactivator EP300 and aberrant transcriptional activities. FEBS Lett 2151-2161 593 16 August 201931234226
1247ZNF580ARP39236_P050Hoffmann, C. J. et al. Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8. Atherosclerosis 216, 103-8 (2011). 2131041421310414
1248ZNF580ARP39236_P050ZNF580 - a brake on Interleukin-6. J Inflamm (Lond). 15, 20 (2018). 3038618230386182
1249OAMA00562Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children. Haematologica 2022 NULL NULL NULL 3563854935638549
1250OPMA04848A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damage. Cell Rep 2021 6 35 109107 3397961233979612
1251OPMA04522Protective heterologous T cell immunity in COVID-19 induced by the trivalent Measles-Mumps-Rubella and Tetanus-Diptheria-Pertussis vaccine antigens. Med (N Y) 2021 NULL NULL NULL 3441438334414383
1252OAMA00655Defining the specificity of recombinant human erythropoietin confirmation in equine samples by liquid chromatography-tandem mass spectrometry. Drug Test Anal 676-689 14 4 April 202234898016
1253OAMA02979Long tail fibres of the novel broad-host-range T-even bacteriophage S16 specifically recognize Salmonella OmpC. Mol Microbiol 818-34 87 4 February 201323289425