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Comprehensive Characterization of Antibodies Targeting Cancer Regulators Using High-Throughput Surface Plasmon Resonance (SPR)
Overview
- The study of Cancer, characterized by cellular regulatory disruptions, demands high-quality tools for dissecting genetic and proteomic changes between cell states.
- Our research focuses on a human proteome-wide toolbox of polyclonal antibodies, targeting key cancer biomarkers like KRAS, STAT3, and Gli1.
- Using the Carterra® LSA™ system, we define kinetic characteristics (on-rates, off-rates, KD values) of these antibodies, showing remarkable 1:1 fit typically seen with monoclonal antibodies.
Key Findings:
- The platform identifies multiple antibody-antigen interactions with KD in the nanomolar to picomolar range.
- It serves as a mass screening tool for developing de novo antibody pairs.
- Our methods improve the characterization of antibodies for translational opportunities in clinical settings.
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Stay ahead in your research. Download our 2022 AACR poster to explore detailed methodologies and findings that could propel your work in cancer biology, translational studies, and clinical applications.
Aviva Systems Biology
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