Product Number |
OAAB16416 |
Product Page |
staging.avivasysbio.com/ulk1-antibody-phospho-s467-oaab16416.html |
Name |
ULK1 Antibody (Phospho-Ser467) (OAAB16416) |
Molecular Weight |
112631 Da |
Isotype |
Ig |
NCBI Gene Id |
8408 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Alias Symbols |
ATG1, ATG1A, UNC51, hATG1, Unc51.1 |
Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB16416 |
Additional Information |
Precautions: ULK1 Antibody (Phospho S467) is for research use only and not for use in diagnostic or therapeutic procedures. |
Additional Information |
Function: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation |
Application Info |
DB: 1:500 |
Immunogen |
This ULK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S467 of human ULK1. |
Additional Information |
Cellular Location: Cytoplasm, cytosol (By similarity). Preautophagosomal structure (By similarity). Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome (By similarity) Tissue Location: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung |
Uniprot ID |
O75385 |
Protein Name |
Serine/threonine-protein kinase ULK1 |
Protein Accession # |
NP_003556.1 |
Gene Symbol |
ULK1 |
Predicted Species Reactivity |
Human |
Application |
DB, ELISA, IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Human |
Image 1 | Phospho-peptide, non-phospho-peptide
| Dot blot analysis of ULK1 Antibody (Phospho S467) Phospho-specific Pab (Cat. # OAAB16416) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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