| Product Number |
ARP54261_P050-Biotin |
| Product Page |
staging.avivasysbio.com/ulk1-antibody-n-terminal-region-biotin-arp54261-p050-biotin.html |
| Name |
ULK1 Antibody - N-terminal region : Biotin (ARP54261_P050-Biotin) |
| Protein Size (# AA) |
1050 amino acids |
| Molecular Weight |
112kDa |
| Conjugation |
Biotin |
| NCBI Gene Id |
8408 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
unc-51-like kinase 1 (C. elegans) |
| Alias Symbols |
ATG1, ATG1A, UNC51, hATG1, Unc51.1 |
| Peptide Sequence |
Synthetic peptide located within the following region: PEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer. |
| Description of Target |
ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation. |
| Protein Interactions |
SESN2; SQSTM1; ATG16L1; EXOC8; EXOC2; BECN1; RALB; AMBRA1; ULK1; UBC; TRAF6; MBP; ATG13; MAP1LC3C; MAP1LC3A; MAP1LC3B; GABARAPL1; GABARAPL2; GABARAP; MLST8; RPTOR; MTOR; PPP1CA; ATG4B; CDC37; G3BP1; RB1CC1; USP10; PRKAG1; PRKAB2; PRKAA2; PRKAA1; SYNGAP1; |
| Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Datasheets/Manuals |
Printable datasheet for anti-ULK1 (ARP54261_P050-Biotin) antibody |
| Blocking Peptide |
For anti-ULK1 (ARP54261_P050-Biotin) antibody is Catalog # AAP54261 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N-terminal region of Human ULK1 |
| Uniprot ID |
O75385 |
| Protein Name |
Serine/threonine-protein kinase ULK1 |
| Protein Accession # |
NP_003556 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_003565 |
| Gene Symbol |
ULK1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
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